ID   GP15L_RAT               Reviewed;          77 AA.
AC   D3ZKM3;
DT   20-DEC-2017, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2013, sequence version 2.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Protein GPR15L {ECO:0000303|PubMed:28900043};
DE   Flags: Precursor;
GN   Name=Gpr15l {ECO:0000303|PubMed:28900043};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RX   PubMed=15057822; DOI=10.1038/nature02426;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [2]
RP   FUNCTION.
RX   PubMed=28900043; DOI=10.1126/scisignal.aal0180;
RA   Suply T., Hannedouche S., Carte N., Li J., Grosshans B., Schaefer M.,
RA   Raad L., Beck V., Vidal S., Hiou-Feige A., Beluch N., Barbieri S.,
RA   Wirsching J., Lageyre N., Hillger F., Debon C., Dawson J., Smith P.,
RA   Lannoy V., Detheux M., Bitsch F., Falchetto R., Bouwmeester T., Porter J.,
RA   Baumgarten B., Mansfield K., Carballido J.M., Seuwen K., Bassilana F.;
RT   "A natural ligand for the orphan receptor GPR15 modulates lymphocyte
RT   recruitment to epithelia.";
RL   Sci. Signal. 10:0-0(2017).
CC   -!- FUNCTION: Chemotactic factor that mediates lymphocytes recruitment to
CC       epithelia through binding and activation of the G-protein coupled
CC       receptor GPR15 (PubMed:28900043). May be a tumor suppressor; together
CC       with SUSD2 has a growth inhibitory effect on colon cancer cells which
CC       includes G1 cell cycle arrest (By similarity).
CC       {ECO:0000250|UniProtKB:Q6UWK7, ECO:0000269|PubMed:28900043}.
CC   -!- FUNCTION: Has antimicrobial activity against Gram-positive bacteria,
CC       including Staphylococcus aureus and Actinomyces spec., and Mycoplasma
CC       hominis and lentivirus. {ECO:0000250|UniProtKB:Q6UWK7}.
CC   -!- SUBUNIT: Interacts with SUSD2; the interaction is direct.
CC       {ECO:0000250|UniProtKB:Q6UWK7}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q6UWK7}.
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DR   EMBL; AC115450; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001099533.2; NM_001106063.2.
DR   AlphaFoldDB; D3ZKM3; -.
DR   STRING; 10116.ENSRNOP00000060855; -.
DR   PaxDb; D3ZKM3; -.
DR   Ensembl; ENSRNOT00000065460; ENSRNOP00000060855; ENSRNOG00000043342.
DR   GeneID; 290595; -.
DR   KEGG; rno:290595; -.
DR   UCSC; RGD:1566160; rat.
DR   RGD; 1566160; LOC290595.
DR   eggNOG; ENOG502TD47; Eukaryota.
DR   GeneTree; ENSGT00390000015172; -.
DR   HOGENOM; CLU_195436_0_0_1; -.
DR   InParanoid; D3ZKM3; -.
DR   OrthoDB; 1583928at2759; -.
DR   PRO; PR:D3ZKM3; -.
DR   Proteomes; UP000002494; Chromosome 16.
DR   Bgee; ENSRNOG00000043342; Expressed in colon and 15 other tissues.
DR   GO; GO:0005576; C:extracellular region; ISO:RGD.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0008009; F:chemokine activity; ISS:UniProtKB.
DR   GO; GO:0001664; F:G protein-coupled receptor binding; ISS:UniProtKB.
DR   GO; GO:0048018; F:receptor ligand activity; ISO:RGD.
DR   GO; GO:0050832; P:defense response to fungus; ISO:RGD.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; ISO:RGD.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0048247; P:lymphocyte chemotaxis; ISS:UniProtKB.
DR   GO; GO:1902807; P:negative regulation of cell cycle G1/S phase transition; ISO:RGD.
DR   GO; GO:0051782; P:negative regulation of cell division; ISO:RGD.
DR   GO; GO:2000404; P:regulation of T cell migration; ISS:UniProtKB.
DR   InterPro; IPR031713; GPR15L.
DR   Pfam; PF15854; GPR15L; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Chemotaxis; Cytokine; Disulfide bond;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000250|UniProtKB:Q6UWK7"
FT   CHAIN           25..77
FT                   /note="Protein GPR15L"
FT                   /id="PRO_5003052873"
FT   DISULFID        37..60
FT                   /evidence="ECO:0000250|UniProtKB:I3LGZ3"
FT   DISULFID        38..57
FT                   /evidence="ECO:0000250|UniProtKB:I3LGZ3"
SQ   SEQUENCE   77 AA;  8807 MW;  76DE2435FD9CA7C4 CRC64;
     MRLLTLSGLF FMLFLCLCVL SSEGRKRPAK FPKLRPCCHL SPRSKPITWK GNHTRPCRPC
     RKLESNSWVV PGALPQI