GP160_HUMAN
ID GP160_HUMAN Reviewed; 338 AA.
AC Q9UJ42; D3DNQ2;
DT 07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Probable G-protein coupled receptor 160;
DE AltName: Full=G-protein coupled receptor GPCR1;
DE Short=hGPCR1;
GN Name=GPR160; Synonyms=GPCR150;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Pancreas;
RX PubMed=11466977; DOI=10.1093/bib/1.1.93;
RA Conklin D., Yee D.P., Millar R., Engelbrecht J., Vissing H.;
RT "Mining of assembled expressed sequence tag (EST) data for protein
RT families: application to the G protein-coupled receptor superfamily.";
RL Brief. Bioinform. 1:93-99(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12044878; DOI=10.1016/s0014-5793(02)02775-8;
RA Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.;
RT "Identification of G protein-coupled receptor genes from the human genome
RT sequence.";
RL FEBS Lett. 520:97-101(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cervix;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Orphan receptor.
CC -!- INTERACTION:
CC Q9UJ42; Q8TAP4-4: LMO3; NbExp=3; IntAct=EBI-25885139, EBI-11742507;
CC Q9UJ42; P17252: PRKCA; NbExp=3; IntAct=EBI-25885139, EBI-1383528;
CC Q9UJ42; Q15047-2: SETDB1; NbExp=3; IntAct=EBI-25885139, EBI-9090795;
CC Q9UJ42; P61981: YWHAG; NbExp=3; IntAct=EBI-25885139, EBI-359832;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AJ249248; CAB55314.1; -; mRNA.
DR EMBL; AB083583; BAB89296.1; -; Genomic_DNA.
DR EMBL; CH471052; EAW78524.1; -; Genomic_DNA.
DR EMBL; CH471052; EAW78525.1; -; Genomic_DNA.
DR EMBL; CH471052; EAW78526.1; -; Genomic_DNA.
DR EMBL; BC000181; AAH00181.1; -; mRNA.
DR CCDS; CCDS3211.1; -.
DR RefSeq; NP_055188.1; NM_014373.2.
DR RefSeq; XP_005247403.1; XM_005247346.3.
DR RefSeq; XP_005247404.1; XM_005247347.3.
DR RefSeq; XP_006713645.1; XM_006713582.3.
DR RefSeq; XP_011510980.1; XM_011512678.2.
DR RefSeq; XP_016861650.1; XM_017006161.1.
DR RefSeq; XP_016861651.1; XM_017006162.1.
DR AlphaFoldDB; Q9UJ42; -.
DR SMR; Q9UJ42; -.
DR BioGRID; 117943; 3.
DR IntAct; Q9UJ42; 4.
DR STRING; 9606.ENSP00000348161; -.
DR BindingDB; Q9UJ42; -.
DR ChEMBL; CHEMBL1777664; -.
DR TCDB; 9.A.14.19.1; the g-protein-coupled receptor (gpcr) family.
DR GlyGen; Q9UJ42; 1 site.
DR iPTMnet; Q9UJ42; -.
DR PhosphoSitePlus; Q9UJ42; -.
DR BioMuta; GPR160; -.
DR DMDM; 48428180; -.
DR PaxDb; Q9UJ42; -.
DR PeptideAtlas; Q9UJ42; -.
DR PRIDE; Q9UJ42; -.
DR Antibodypedia; 1940; 231 antibodies from 28 providers.
DR DNASU; 26996; -.
DR Ensembl; ENST00000355897.10; ENSP00000348161.5; ENSG00000173890.17.
DR GeneID; 26996; -.
DR KEGG; hsa:26996; -.
DR MANE-Select; ENST00000355897.10; ENSP00000348161.5; NM_014373.3; NP_055188.1.
DR UCSC; uc003fgi.4; human.
DR CTD; 26996; -.
DR DisGeNET; 26996; -.
DR GeneCards; GPR160; -.
DR HGNC; HGNC:23693; GPR160.
DR HPA; ENSG00000173890; Tissue enhanced (bone marrow, parathyroid gland).
DR neXtProt; NX_Q9UJ42; -.
DR OpenTargets; ENSG00000173890; -.
DR PharmGKB; PA134936972; -.
DR VEuPathDB; HostDB:ENSG00000173890; -.
DR eggNOG; ENOG502RTG9; Eukaryota.
DR GeneTree; ENSGT00390000015520; -.
DR HOGENOM; CLU_826300_0_0_1; -.
DR InParanoid; Q9UJ42; -.
DR OMA; AIRITSY; -.
DR OrthoDB; 1279495at2759; -.
DR PhylomeDB; Q9UJ42; -.
DR TreeFam; TF335541; -.
DR PathwayCommons; Q9UJ42; -.
DR SignaLink; Q9UJ42; -.
DR BioGRID-ORCS; 26996; 11 hits in 1063 CRISPR screens.
DR ChiTaRS; GPR160; human.
DR GeneWiki; GPR160; -.
DR GenomeRNAi; 26996; -.
DR Pharos; Q9UJ42; Tbio.
DR PRO; PR:Q9UJ42; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q9UJ42; protein.
DR Bgee; ENSG00000173890; Expressed in ileal mucosa and 145 other tissues.
DR ExpressionAtlas; Q9UJ42; baseline and differential.
DR Genevisible; Q9UJ42; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR GO; GO:0043235; C:receptor complex; IDA:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR042353; GPR160.
DR PANTHER; PTHR15573; PTHR15573; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..338
FT /note="Probable G-protein coupled receptor 160"
FT /id="PRO_0000069643"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..44
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 45..58
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..93
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 115..136
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..177
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 178..198
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 199..244
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..265
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 266..268
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..338
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 8
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 338 AA; 39787 MW; 50B38F90E0311175 CRC64;
MTALSSENCS FQYQLRQTNQ PLDVNYLLFL IILGKILLNI LTLGMRRKNT CQNFMEYFCI
SLAFVDLLLL VNISIILYFR DFVLLSIRFT KYHICLFTQI ISFTYGFLHY PVFLTACIDY
CLNFSKTTKL SFKCQKLFYF FTVILIWISV LAYVLGDPAI YQSLKAQNAY SRHCPFYVSI
QSYWLSFFMV MILFVAFITC WEEVTTLVQA IRITSYMNET ILYFPFSSHS SYTVRSKKIF
LSKLIVCFLS TWLPFVLLQV IIVLLKVQIP AYIEMNIPWL YFVNSFLIAT VYWFNCHKLN
LKDIGLPLDP FVNWKCCFIP LTIPNLEQIE KPISIMIC
