GP160_MOUSE
ID GP160_MOUSE Reviewed; 336 AA.
AC Q3U3F9; Q9D9Y9;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Probable G-protein coupled receptor 160;
GN Name=Gpr160;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: Orphan receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB24531.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK006330; BAB24531.1; ALT_FRAME; mRNA.
DR EMBL; AK154620; BAE32719.1; -; mRNA.
DR EMBL; AK154784; BAE32827.1; -; mRNA.
DR CCDS; CCDS50883.1; -.
DR RefSeq; NP_001127857.1; NM_001134385.2.
DR RefSeq; NP_001127858.1; NM_001134386.2.
DR RefSeq; NP_001273923.1; NM_001286994.1.
DR RefSeq; NP_001273924.1; NM_001286995.1.
DR RefSeq; NP_001273925.1; NM_001286996.1.
DR RefSeq; NP_082241.1; NM_027965.2.
DR RefSeq; XP_006535602.1; XM_006535539.2.
DR RefSeq; XP_017175222.1; XM_017319733.1.
DR RefSeq; XP_017175223.1; XM_017319734.1.
DR RefSeq; XP_017175224.1; XM_017319735.1.
DR RefSeq; XP_017175225.1; XM_017319736.1.
DR RefSeq; XP_017175226.1; XM_017319737.1.
DR AlphaFoldDB; Q3U3F9; -.
DR SMR; Q3U3F9; -.
DR STRING; 10090.ENSMUSP00000103893; -.
DR GlyGen; Q3U3F9; 1 site.
DR PhosphoSitePlus; Q3U3F9; -.
DR PaxDb; Q3U3F9; -.
DR PRIDE; Q3U3F9; -.
DR ProteomicsDB; 267656; -.
DR Antibodypedia; 1940; 231 antibodies from 28 providers.
DR DNASU; 71862; -.
DR Ensembl; ENSMUST00000046748; ENSMUSP00000045165; ENSMUSG00000037661.
DR Ensembl; ENSMUST00000108258; ENSMUSP00000103893; ENSMUSG00000037661.
DR Ensembl; ENSMUST00000108259; ENSMUSP00000103894; ENSMUSG00000037661.
DR Ensembl; ENSMUST00000108261; ENSMUSP00000103896; ENSMUSG00000037661.
DR Ensembl; ENSMUST00000166278; ENSMUSP00000128666; ENSMUSG00000037661.
DR GeneID; 71862; -.
DR KEGG; mmu:71862; -.
DR UCSC; uc008ovi.3; mouse.
DR CTD; 26996; -.
DR MGI; MGI:1919112; Gpr160.
DR VEuPathDB; HostDB:ENSMUSG00000037661; -.
DR eggNOG; ENOG502RTG9; Eukaryota.
DR GeneTree; ENSGT00390000015520; -.
DR HOGENOM; CLU_826300_0_0_1; -.
DR InParanoid; Q3U3F9; -.
DR OMA; AIRITSY; -.
DR OrthoDB; 1279495at2759; -.
DR PhylomeDB; Q3U3F9; -.
DR TreeFam; TF335541; -.
DR BioGRID-ORCS; 71862; 3 hits in 73 CRISPR screens.
DR ChiTaRS; Gpr160; mouse.
DR PRO; PR:Q3U3F9; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q3U3F9; protein.
DR Bgee; ENSMUSG00000037661; Expressed in spermatocyte and 122 other tissues.
DR ExpressionAtlas; Q3U3F9; baseline and differential.
DR Genevisible; Q3U3F9; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0043235; C:receptor complex; ISO:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR042353; GPR160.
DR PANTHER; PTHR15573; PTHR15573; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..336
FT /note="Probable G-protein coupled receptor 160"
FT /id="PRO_0000069644"
FT TOPO_DOM 1..20
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 21..41
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 42..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..95
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 117..136
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..186
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..207
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 208..243
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 265..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 294..336
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 8
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 21
FT /note="L -> F (in Ref. 1; BAB24531)"
FT /evidence="ECO:0000305"
FT CONFLICT 183
FT /note="H -> R (in Ref. 1; BAB24531)"
FT /evidence="ECO:0000305"
FT CONFLICT 203
FT /note="E -> K (in Ref. 1; BAB24531)"
FT /evidence="ECO:0000305"
FT CONFLICT 207..208
FT /note="LL -> VF (in Ref. 1; BAB24531)"
FT /evidence="ECO:0000305"
FT CONFLICT 300
FT /note="D -> I (in Ref. 1; BAB24531)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 336 AA; 38922 MW; E2AF0DCB28B36B95 CRC64;
MTALSSKNCS LQYQLHQSPQ LLEASCLLFL IILGKVLLNI LLLRVRRGDA RWTLMEYFCF
SLALVDLLLL VNISILTYFR DFVVLGIRFT RYHICLLTQI ISFTYGFLHY PVCSLACIDY
WCNLSRASKQ SSRWQKLLYF LTVILTWISV LAYVLVDPAI SVSLKAHRGY VYQCPAYVST
QSHWLSLSML MVLFVAFLIS WQEVVALLQA MRIASYKSKA ALYFPFPLHC GYALSCREAL
LPRLIVCFLG TWFPFVALQV LILSLRVQIP AYIEMNVPWL YFVNSFLIAA VYWFNCHKLD
LRDSSLPVDP FINWKCCFVP VHRLKQVERP MSIVIC
