GP162_HUMAN
ID GP162_HUMAN Reviewed; 588 AA.
AC Q16538; Q16664; Q59EH5; Q66K56;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Probable G-protein coupled receptor 162;
DE AltName: Full=Gene-rich cluster gene A protein;
GN Name=GPR162; Synonyms=GRCA;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2).
RX PubMed=8723724; DOI=10.1101/gr.6.4.314;
RA Ansari-Lari M.A., Muzny D.M., Lu J., Lu F., Lilley C.E., Spanos S.,
RA Malley T., Gibbs R.A.;
RT "A gene-rich cluster between the CD4 and triosephosphate isomerase genes at
RT human chromosome 12p13.";
RL Genome Res. 6:314-326(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9074930; DOI=10.1101/gr.7.3.268;
RA Ansari-Lari M.A., Shen Y., Muzny D.M., Lee W., Gibbs R.A.;
RT "Large-scale sequencing in human chromosome 12p13: experimental and
RT computational gene structure determination.";
RL Genome Res. 7:268-280(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT GLY-459.
RC TISSUE=Brain, and Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 21-588 (ISOFORM 1).
RC TISSUE=Brain;
RA Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.,
RA Ohara O., Nagase T., Kikuno R.F.;
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Orphan receptor.
CC -!- INTERACTION:
CC Q16538; Q9UMX0: UBQLN1; NbExp=3; IntAct=EBI-22387200, EBI-741480;
CC Q16538; Q9UHD9: UBQLN2; NbExp=3; IntAct=EBI-22387200, EBI-947187;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=A-2;
CC IsoId=Q16538-1; Sequence=Displayed;
CC Name=2; Synonyms=A-1;
CC IsoId=Q16538-2; Sequence=VSP_016302, VSP_016303;
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U47924; AAB51310.1; -; Genomic_DNA.
DR EMBL; U47924; AAB51311.1; -; Genomic_DNA.
DR EMBL; U47925; AAC50463.1; -; mRNA.
DR EMBL; U47928; AAC50466.1; -; mRNA.
DR EMBL; BC002353; AAH02353.1; -; mRNA.
DR EMBL; BC080585; AAH80585.1; -; mRNA.
DR EMBL; AB209836; BAD93073.1; -; mRNA.
DR CCDS; CCDS44819.1; -. [Q16538-2]
DR CCDS; CCDS8563.1; -. [Q16538-1]
DR RefSeq; NP_055264.1; NM_014449.1. [Q16538-2]
DR RefSeq; NP_062832.1; NM_019858.1. [Q16538-1]
DR AlphaFoldDB; Q16538; -.
DR SMR; Q16538; -.
DR BioGRID; 118087; 4.
DR IntAct; Q16538; 3.
DR MINT; Q16538; -.
DR STRING; 9606.ENSP00000311528; -.
DR ChEMBL; CHEMBL4523871; -.
DR GlyGen; Q16538; 1 site.
DR iPTMnet; Q16538; -.
DR PhosphoSitePlus; Q16538; -.
DR BioMuta; GPR162; -.
DR DMDM; 74754516; -.
DR MassIVE; Q16538; -.
DR PaxDb; Q16538; -.
DR PeptideAtlas; Q16538; -.
DR PRIDE; Q16538; -.
DR ProteomicsDB; 60899; -. [Q16538-1]
DR ProteomicsDB; 60900; -. [Q16538-2]
DR Antibodypedia; 41966; 116 antibodies from 25 providers.
DR DNASU; 27239; -.
DR Ensembl; ENST00000311268.8; ENSP00000311528.3; ENSG00000250510.8. [Q16538-1]
DR Ensembl; ENST00000428545.6; ENSP00000399670.2; ENSG00000250510.8. [Q16538-2]
DR GeneID; 27239; -.
DR KEGG; hsa:27239; -.
DR MANE-Select; ENST00000311268.8; ENSP00000311528.3; NM_019858.2; NP_062832.1.
DR UCSC; uc001qqw.2; human. [Q16538-1]
DR CTD; 27239; -.
DR DisGeNET; 27239; -.
DR GeneCards; GPR162; -.
DR HGNC; HGNC:16693; GPR162.
DR HPA; ENSG00000250510; Group enriched (brain, choroid plexus).
DR neXtProt; NX_Q16538; -.
DR OpenTargets; ENSG00000250510; -.
DR PharmGKB; PA142671713; -.
DR VEuPathDB; HostDB:ENSG00000250510; -.
DR eggNOG; ENOG502QVAA; Eukaryota.
DR GeneTree; ENSGT00390000017213; -.
DR HOGENOM; CLU_031636_2_0_1; -.
DR InParanoid; Q16538; -.
DR OMA; KRDSRDI; -.
DR PhylomeDB; Q16538; -.
DR TreeFam; TF330832; -.
DR PathwayCommons; Q16538; -.
DR SignaLink; Q16538; -.
DR BioGRID-ORCS; 27239; 11 hits in 1064 CRISPR screens.
DR ChiTaRS; GPR162; human.
DR GeneWiki; GPR162; -.
DR GenomeRNAi; 27239; -.
DR Pharos; Q16538; Tbio.
DR PRO; PR:Q16538; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q16538; protein.
DR Bgee; ENSG00000250510; Expressed in right hemisphere of cerebellum and 121 other tissues.
DR ExpressionAtlas; Q16538; baseline and differential.
DR Genevisible; Q16538; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR InterPro; IPR022347; GCR_153/162.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR022348; GPR162.
DR PANTHER; PTHR16518; PTHR16518; 1.
DR PANTHER; PTHR16518:SF6; PTHR16518:SF6; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR01991; GPR153GPR162.
DR PRINTS; PR01993; GPR162.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; G-protein coupled receptor;
KW Glycoprotein; Membrane; Phosphoprotein; Receptor; Reference proteome;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..588
FT /note="Probable G-protein coupled receptor 162"
FT /id="PRO_0000069647"
FT TOPO_DOM 1..17
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 18..38
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 39..49
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..70
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 71..91
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..112
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 113..133
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 155..174
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 175..195
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 196..275
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..296
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 297..303
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 304..324
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 325..588
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 445..474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 511..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 413
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q3UN16"
FT MOD_RES 435
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q3UN16"
FT CARBOHYD 86
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..284
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:8723724"
FT /id="VSP_016302"
FT VAR_SEQ 285..289
FT /note="GVPIL -> MLSTG (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:8723724"
FT /id="VSP_016303"
FT VARIANT 459
FT /note="R -> G (in dbSNP:rs11612427)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_049407"
SQ SEQUENCE 588 AA; 63930 MW; 746BBE0BD83C8566 CRC64;
MARGGAGAEE ASLRSNALSW LACGLLALLA NAWIILSISA KQQKHKPLEL LLCFLAGTHI
LMAAVPLTTF AVVQLRRQAS SDYDWNESIC KVFVSTYYTL ALATCFTVAS LSYHRMWMVR
WPVNYRLSNA KKQALHAVMG IWMVSFILST LPSIGWHNNG ERYYARGCQF IVSKIGLGFG
VCFSLLLLGG IVMGLVCVAI TFYQTLWARP RRARQARRVG GGGGTKAGGP GALGTRPAFE
VPAIVVEDAR GKRRSSLDGS ESAKTSLQVT NLVSAIVFLY DSLTGVPILV VSFFSLKSDS
APPWMVLAVL WCSMAQTLLL PSFIWSCERY RADVRTVWEQ CVAIMSEEDG DDDGGCDDYA
EGRVCKVRFD ANGATGPGSR DPAQVKLLPG RHMLFPPLER VHYLQVPLSR RLSHDETNIF
STPREPGSFL HKWSSSDDIR VLPAQSRALG GPPEYLGQRH RLEDEEDEEE AEGGGLASLR
QFLESGVLGS GGGPPRGPGF FREEITTFID ETPLPSPTAS PGHSPRRPRP LGLSPRRLSL
GSPESRAVGL PLGLSAGRRC SLTGGEESAR AWGGSWGPGN PIFPQLTL
