ID   GP168_BPTWO             Reviewed;          74 AA.
AC   Q4Z971;
DT   24-JUN-2015, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 1.
DT   03-AUG-2022, entry version 27.
DE   RecName: Full=Gene product 168 {ECO:0000305};
DE            Short=gp168;
OS   Staphylococcus phage Twort (strain DSM 17442 / HER 48) (Bacteriophage
OS   Twort).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Herelleviridae; Twortvirinae; Twortvirus.
OX   NCBI_TaxID=1283338;
OH   NCBI_TaxID=55510; Staphylococcus virus Twort.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15788529; DOI=10.1073/pnas.0501140102;
RA   Kwan T., Liu J., DuBow M., Gros P., Pelletier J.;
RT   "The complete genomes and proteomes of 27 Staphylococcus aureus
RT   bacteriophages.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:5174-5179(2005).
RN   [2]
RP   FUNCTION.
RX   PubMed=17010157; DOI=10.1111/j.1365-2958.2006.05427.x;
RA   Belley A., Callejo M., Arhin F., Dehbi M., Fadhil I., Liu J., McKay G.,
RA   Srikumar R., Bauda P., Bergeron D., Ha N., Dubow M., Gros P., Pelletier J.,
RA   Moeck G.;
RT   "Competition of bacteriophage polypeptides with native replicase proteins
RT   for binding to the DNA sliding clamp reveals a novel mechanism for DNA
RT   replication arrest in Staphylococcus aureus.";
RL   Mol. Microbiol. 62:1132-1143(2006).
CC   -!- FUNCTION: Targets the host DNA sliding clamp and inhibits host DNA
CC       replication. {ECO:0000269|PubMed:17010157}.
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DR   EMBL; AY954970; AAX92440.1; -; Genomic_DNA.
DR   RefSeq; YP_238634.1; NC_007021.1.
DR   SMR; Q4Z971; -.
DR   GeneID; 5130347; -.
DR   KEGG; vg:5130347; -.
DR   Proteomes; UP000001466; Genome.
DR   GO; GO:0098673; P:inhibition of host DNA replication by virus; IEA:UniProtKB-KW.
DR   GO; GO:0060153; P:modulation by virus of host cell cycle; IEA:UniProtKB-KW.
PE   4: Predicted;
KW   Coiled coil; Host-virus interaction;
KW   Inhibition of host DNA replication by virus;
KW   Modulation of host cell cycle by virus; Reference proteome.
FT   CHAIN           1..74
FT                   /note="Gene product 168"
FT                   /id="PRO_0000433210"
FT   COILED          19..73
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   74 AA;  8989 MW;  CB94D59CD7EB6C38 CRC64;
     MLFFKEKFYN ELSYYRGGHK DLESMFELAL EYIEKLEEED EQQVTDYENA MEEELRDAVD
     VIESQLEIIK DIVR