GP171_BOVIN
ID GP171_BOVIN Reviewed; 319 AA.
AC Q3ZBK9;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2005, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=G-protein coupled receptor 171;
GN Name=GPR171;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Thymus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: G-protein coupled receptor for Big LEN, a 16-amino acid
CC neuropeptide produced from the precursor protein, proSAAS (encoded by
CC PCSK1N). Acts through a G(i)-alpha-mediated pathway in response to
CC bigLEN. Big LEN-GPR171 system plays an important role in regulating
CC feeding and metabolism. Also plays a role in modulating fear and
CC anxiety-like behaviors in the basolateral amygdala. Big LEN-GPR171
CC modulates the mu-type opioid receptor signaling and antinociception.
CC Acts as a negative regulator T cell function.
CC {ECO:0000250|UniProtKB:Q8BG55}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8BG55};
CC Multi-pass membrane protein {ECO:0000255}. Note=Colocalized with GPR83
CC in the paraventricular nucleus. {ECO:0000250|UniProtKB:Q8BG55}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; BC103237; AAI03238.1; -; mRNA.
DR RefSeq; NP_001070470.1; NM_001077002.1.
DR RefSeq; XP_005201884.1; XM_005201827.3.
DR AlphaFoldDB; Q3ZBK9; -.
DR SMR; Q3ZBK9; -.
DR STRING; 9913.ENSBTAP00000012983; -.
DR PaxDb; Q3ZBK9; -.
DR PRIDE; Q3ZBK9; -.
DR Ensembl; ENSBTAT00000012983; ENSBTAP00000012983; ENSBTAG00000009848.
DR GeneID; 767929; -.
DR KEGG; bta:767929; -.
DR CTD; 29909; -.
DR VEuPathDB; HostDB:ENSBTAG00000009848; -.
DR VGNC; VGNC:29569; GPR171.
DR eggNOG; ENOG502QTCA; Eukaryota.
DR GeneTree; ENSGT01050000244845; -.
DR HOGENOM; CLU_009579_8_2_1; -.
DR InParanoid; Q3ZBK9; -.
DR OMA; WHVFTNF; -.
DR OrthoDB; 1087125at2759; -.
DR TreeFam; TF330969; -.
DR Proteomes; UP000009136; Chromosome 1.
DR Bgee; ENSBTAG00000009848; Expressed in thymus and 92 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008528; F:G protein-coupled peptide receptor activity; ISS:UniProtKB.
DR GO; GO:0045028; F:G protein-coupled purinergic nucleotide receptor activity; IBA:GO_Central.
DR GO; GO:0042923; F:neuropeptide binding; ISS:UniProtKB.
DR GO; GO:0008188; F:neuropeptide receptor activity; ISS:UniProtKB.
DR GO; GO:0007188; P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0045638; P:negative regulation of myeloid cell differentiation; IEA:Ensembl.
DR GO; GO:0060259; P:regulation of feeding behavior; ISS:UniProtKB.
DR GO; GO:0051930; P:regulation of sensory perception of pain; ISS:UniProtKB.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..319
FT /note="G-protein coupled receptor 171"
FT /id="PRO_0000245014"
FT TOPO_DOM 1..21
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 22..42
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 43..48
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 49..69
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 70..89
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 90..110
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 111..132
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..153
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 154..181
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 182..202
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 203..224
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 225..245
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 246..268
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..319
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 3
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 319 AA; 36780 MW; B2082B6F61D8441B CRC64;
MTNSSTFCPV YRDLEPFTYF FYLVFLIGII GSCFATWAFI QKNTNHRCVS IYLINLLTAD
FLLTLALPVK ITVDLGVAPW KLRIFHCQVT ACLIYINMYL SIIFLAFVSI DRCLQLTYSC
KIYRIQEPGF AKMISAVVWL MVLLIMVPNM IIPIKDIKEK PNVGCMEFKS EFGRNWHLLT
NFISIAIFFN FSAIILISNC LVIRQLYRNK DNENYPNVKR ALISILLVTT GYIICFVPYH
IVRIPYTLSQ TEVISDCSTR ISLFKAKEAT LLLAVSNLCF DPILYYHLSK AFRLKITETF
ASHKESKAQK EKPRSENNA
