GP173_DANRE
ID GP173_DANRE Reviewed; 387 AA.
AC Q9I918;
DT 14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Probable G-protein coupled receptor 173;
DE AltName: Full=Super conserved receptor expressed in brain 3;
GN Name=gpr173; Synonyms=sreb3;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10833454; DOI=10.1006/bbrc.2000.2829;
RA Matsumoto M., Saito T., Takasaki J., Kamohara M., Sugimoto T.,
RA Kobayashi M., Tadokoro M., Matsumoto S., Ohishi T., Furuichi K.;
RT "An evolutionarily conserved G-protein coupled receptor family, SREB,
RT expressed in the central nervous system.";
RL Biochem. Biophys. Res. Commun. 272:576-582(2000).
CC -!- FUNCTION: Is a receptor for the SMIM20 derived peptides Phoenixin-14
CC and Phoenixin-20 (By similarity). It mediates the Phoenixin-14 and
CC Phoenixin-20 augmentation of gonadotropin-releasing hormone (GNRH)
CC signaling in the hypothalamus and pituitary gland (By similarity). In
CC the ovary, it mediates the effects of Phoenixin-14 and Phoenixin-20
CC induced granulosa cell proliferation during follicular growth (By
CC similarity). {ECO:0000250|UniProtKB:Q9JJH2,
CC ECO:0000250|UniProtKB:Q9NS66}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AB040806; BAA96652.1; -; Genomic_DNA.
DR RefSeq; NP_571573.1; NM_131498.1.
DR RefSeq; XP_005167115.1; XM_005167058.3.
DR AlphaFoldDB; Q9I918; -.
DR SMR; Q9I918; -.
DR STRING; 7955.ENSDARP00000063004; -.
DR PaxDb; Q9I918; -.
DR Ensembl; ENSDART00000063005; ENSDARP00000063004; ENSDARG00000042922.
DR GeneID; 57926; -.
DR KEGG; dre:57926; -.
DR CTD; 54328; -.
DR ZFIN; ZDB-GENE-000710-1; gpr173.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00890000139436; -.
DR HOGENOM; CLU_055518_0_0_1; -.
DR InParanoid; Q9I918; -.
DR OMA; ACTVPHR; -.
DR OrthoDB; 1311948at2759; -.
DR PhylomeDB; Q9I918; -.
DR TreeFam; TF331163; -.
DR PRO; PR:Q9I918; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 8.
DR Bgee; ENSDARG00000042922; Expressed in brain and 7 other tissues.
DR ExpressionAtlas; Q9I918; baseline.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..387
FT /note="Probable G-protein coupled receptor 173"
FT /id="PRO_0000069653"
FT TOPO_DOM 1..40
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 41..61
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 62..87
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 109..111
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 112..132
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 133..153
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 154..174
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 175..202
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..223
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 224..301
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 302..322
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 323..335
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 336..356
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 357..387
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 198
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 110..188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 387 AA; 43410 MW; 5E094EFD44120871 CRC64;
MANGNASSDG PGNPLAAVVS TTGGVMGGAP SSAVSTYVKL VLLGLIICIS LVGNLVVSLL
VLRDRALHKA PYYFLLDLCL ADTIRSAVCF PFVLVSIKNG SAWTYSVLSC KVVAFMAVLF
CFHAAFMLFC ISVTRYMAIA HHRFYSKRMT FWTCVAVVCM VWTLSVAMAF PPVFDVGTYK
FIREEDQCIF EHRYFKANDT LGFMLMLAVL ILATHVVYMK LLLFEYKHRK MKPVQMVPAI
SQNWTFHGPG ATGQAAANWI AGFGRGPMPP TLLGIRQNLH NQNRRLLGME EFKAEKQLGR
MFYVITLFFL VLWSPYIVAC YWRVFVKACT IPHRYLSTTV WMSFAQAGVN PIICFFLNKD
LKKGLLAHLP PCCRTPPQLP REPYCVM
