GP173_RAT
ID GP173_RAT Reviewed; 373 AA.
AC Q9JJH2;
DT 14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Probable G-protein coupled receptor 173;
DE AltName: Full=Super conserved receptor expressed in brain 3;
GN Name=Gpr173; Synonyms=Sreb3;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=10833454; DOI=10.1006/bbrc.2000.2829;
RA Matsumoto M., Saito T., Takasaki J., Kamohara M., Sugimoto T.,
RA Kobayashi M., Tadokoro M., Matsumoto S., Ohishi T., Furuichi K.;
RT "An evolutionarily conserved G-protein coupled receptor family, SREB,
RT expressed in the central nervous system.";
RL Biochem. Biophys. Res. Commun. 272:576-582(2000).
RN [2]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=27440717; DOI=10.1152/ajpregu.00191.2016;
RA Stein L.M., Tullock C.W., Mathews S.K., Garcia-Galiano D., Elias C.F.,
RA Samson W.K., Yosten G.L.;
RT "Hypothalamic action of phoenixin to control reproductive hormone secretion
RT in females: importance of the orphan G protein-coupled receptor Gpr173.";
RL Am. J. Physiol. 311:R489-R496(2016).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=30251651; DOI=10.1016/j.bbalip.2018.09.006;
RA Billert M., Wojciechowicz T., Jasaszwili M., Szczepankiewicz D., Wasko J.,
RA Kazmierczak S., Strowski M.Z., Nowak K.W., Skrzypski M.;
RT "Phoenixin-14 stimulates differentiation of 3T3-L1 preadipocytes via
RT cAMP/Epac-dependent mechanism.";
RL Biochim. Biophys. Acta 1863:1449-1457(2018).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=31422055; DOI=10.1016/j.bbamcr.2019.118533;
RA Billert M., Kolodziejski P.A., Strowski M.Z., Nowak K.W., Skrzypski M.;
RT "Phoenixin-14 stimulates proliferation and insulin secretion in insulin
RT producing INS-1E cells.";
RL Biochim. Biophys. Acta 1866:118533-118533(2019).
CC -!- FUNCTION: Is a receptor for the SMIM20 derived peptides Phoenixin-14
CC and Phoenixin-20 (PubMed:27440717). It mediates the Phoenixin-14 and
CC Phoenixin-20 augmentation of gonadotropin-releasing hormone (GNRH)
CC signaling in the hypothalamus and pituitary gland (PubMed:27440717). In
CC the ovary, it mediates the effects of Phoenixin-14 and Phoenixin-20
CC induced granulosa cell proliferation during follicular growth (By
CC similarity). {ECO:0000250|UniProtKB:Q9NS66,
CC ECO:0000269|PubMed:27440717}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Expressed in the brain, preadipocytes and
CC pancreatic islet cells. {ECO:0000269|PubMed:27440717,
CC ECO:0000269|PubMed:30251651, ECO:0000269|PubMed:31422055}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AB040804; BAA96650.1; -; mRNA.
DR RefSeq; NP_071591.1; NM_022255.1.
DR AlphaFoldDB; Q9JJH2; -.
DR SMR; Q9JJH2; -.
DR GlyGen; Q9JJH2; 2 sites.
DR PhosphoSitePlus; Q9JJH2; -.
DR Ensembl; ENSRNOT00000079982; ENSRNOP00000096581; ENSRNOG00000060137.
DR GeneID; 64021; -.
DR KEGG; rno:64021; -.
DR CTD; 54328; -.
DR RGD; 620748; Gpr173.
DR GeneTree; ENSGT00890000139436; -.
DR InParanoid; Q9JJH2; -.
DR OrthoDB; 1311948at2759; -.
DR PhylomeDB; Q9JJH2; -.
DR PRO; PR:Q9JJH2; -.
DR Proteomes; UP000002494; Chromosome X.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0004968; F:gonadotropin-releasing hormone receptor activity; ISO:RGD.
DR GO; GO:2001223; P:negative regulation of neuron migration; ISO:RGD.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..373
FT /note="Probable G-protein coupled receptor 173"
FT /id="PRO_0000069652"
FT TOPO_DOM 1..26
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 27..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..59
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..80
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..188
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 189..209
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 210..287
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..308
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 309..322
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 323..343
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 344..373
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 3
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 184
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 96..174
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 373 AA; 41511 MW; C06DEA2F0E88CAF5 CRC64;
MANTTGEPEE VSGALSLPSA SAYVKLVLLG LIMCVSLAGN AILSLLVLKE RALHKAPYYF
LLDLCLADGI RSAICFPFVL ASVRHGSSWT FSALSCKIVA FMAVLFCFHA AFMLFCISVT
RYMAIAHHRF YAKRMTLWTC AAVICMAWTL SVAMAFPPVF DVGTYKFIRE EDQCIFEHRY
FKANDTLGFM LMLAVLMAAT HAVYGKLLLF EYRHRKMKPV QMVPAISQNW TFHGPGATGQ
AAANWIAGFG RGPMPPTLLG IRQNGHAASR RLLGMDEVKG EKQLGRMFYA ITLLFLLLWS
PYIVACYWRV FVKACAVPHR YLATAVWMSF AQAAVNPIVC FLLNKDLKKC LRTHAPCWGT
GGAPAPREPY CVM
