GP176_RAT
ID GP176_RAT Reviewed; 513 AA.
AC Q64017; Q63231;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 2.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Probable G-protein coupled receptor 176;
DE AltName: Full=G-protein coupled receptor AGR9;
DE AltName: Full=RBU-15;
GN Name=Gpr176; Synonyms=Agr9, Gm1012;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Aortic smooth muscle;
RX PubMed=8018717; DOI=10.1016/0167-4781(94)90007-8;
RA Ishizaka N., Okazaki H., Kurokawa K., Kumada M., Takuwa Y.;
RT "Molecular cloning of a novel putative G protein-coupled receptor from rat
RT aortic smooth muscle. Downregulation of the mRNA level by the cyclic AMP
RT messenger pathway.";
RL Biochim. Biophys. Acta 1218:173-180(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 67-506.
RC STRAIN=Sprague-Dawley; TISSUE=Brain;
RX PubMed=7893747; DOI=10.1016/0167-4781(95)00002-x;
RA Hata S., Emi Y., Iyanagi T., Osumi T.;
RT "cDNA cloning of a putative G protein-coupled receptor from brain.";
RL Biochim. Biophys. Acta 1261:121-125(1995).
CC -!- FUNCTION: Orphan receptor involved in normal circadian rhythm behavior.
CC Acts through the G-protein subclass G(z)-alpha and has an agonist-
CC independent basal activity to repress cAMP production.
CC {ECO:0000250|UniProtKB:Q80WT4}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q80WT4};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Expressed in brain, lung, heart, stomach,
CC intestine, cultured aortic smooth muscle cells and cardiac myocytes.
CC {ECO:0000269|PubMed:8018717}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB31153.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; S73608; AAB31153.1; ALT_FRAME; mRNA.
DR EMBL; D38450; BAA07482.1; -; mRNA.
DR RefSeq; NP_001257915.1; NM_001270986.1.
DR AlphaFoldDB; Q64017; -.
DR SMR; Q64017; -.
DR STRING; 10116.ENSRNOP00000007882; -.
DR GlyGen; Q64017; 4 sites.
DR PhosphoSitePlus; Q64017; -.
DR PaxDb; Q64017; -.
DR Ensembl; ENSRNOT00000007882; ENSRNOP00000007882; ENSRNOG00000005971.
DR GeneID; 117257; -.
DR KEGG; rno:117257; -.
DR UCSC; RGD:621718; rat.
DR CTD; 11245; -.
DR RGD; 621718; Gpr176.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00950000182998; -.
DR HOGENOM; CLU_045778_0_0_1; -.
DR InParanoid; Q64017; -.
DR OMA; MVMIFIF; -.
DR OrthoDB; 602137at2759; -.
DR PhylomeDB; Q64017; -.
DR TreeFam; TF331506; -.
DR PRO; PR:Q64017; -.
DR Proteomes; UP000002494; Chromosome 3.
DR Bgee; ENSRNOG00000005971; Expressed in ovary and 18 other tissues.
DR Genevisible; Q64017; RN.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0004930; F:G protein-coupled receptor activity; ISS:UniProtKB.
DR GO; GO:0007193; P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; ISO:RGD.
DR GO; GO:0048512; P:circadian behavior; ISS:UniProtKB.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR CDD; cd15006; 7tmA_GPR176; 1.
DR InterPro; IPR043523; GPCR_176_Rhodpsn_7TM.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Biological rhythms; Cell membrane; G-protein coupled receptor;
KW Glycoprotein; Membrane; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..513
FT /note="Probable G-protein coupled receptor 176"
FT /id="PRO_0000069658"
FT TOPO_DOM 1..41
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 42..64
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 65..77
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 78..98
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 99..108
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 109..129
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 130..157
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 158..177
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 178..204
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 205..225
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 226..264
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 265..285
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 286..301
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 302..322
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 323..513
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 404..432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 4
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 11
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 17
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 26
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 210
FT /note="V -> I (in Ref. 1; AAB31153)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 513 AA; 56785 MW; EF191707F723FE2E CRC64;
MGHNGSWVSP NTSHPRNTSG AQAGANSSAF GELSEAQLYR QFTTTVQVVI FIGSLLGNFT
VLWSTCRTTV FKSVTNRFIK NLACSGICAS VVCVPFDIIL STSPHCCWWI YTMLFCKVLK
FLHKVFCSVT VLSFPAIALD RYYSVLYPLE RKISDAKSRE LVMYIWAHAV VASVPVFAVT
NVADIYATST CTEVWSNSLG HLVYVLIYNV TTVIVPVAVV FLFLILIRRA LSASQKKKVI
IAALRTPQNT ISIPYASQRE AELHATLLSM VTVFILCSVP YATLVVYQTV LNVPNTSVFL
LLTAIWLPKV SLLANPVLFL TVNRSVRKCL VGTLVQLHHR YSRRNVVSTG SGVVEPSLEP
SMRSGSQLLE MFHIGQQQIF KPSEDEEESE AKYLGSTDFQ AKEVLTSSPE GEESQLAPSV
PPPGTVDSVS RVSPVAPVEP GIFPDKYSLQ FGFGPFELPP QWLSETRNSK KRLLPPLGNT
PEELIQTKVP RVSRVERKMS RNNKVSIFPK VDS
