GP180_HUMAN
ID GP180_HUMAN Reviewed; 440 AA.
AC Q86V85; A8K1D5;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Integral membrane protein GPR180;
DE AltName: Full=Intimal thickness-related receptor;
DE Flags: Precursor;
GN Name=GPR180; Synonyms=ITR;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057823; DOI=10.1038/nature02379;
RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA Rogers J., Ross M.T.;
RT "The DNA sequence and analysis of human chromosome 13.";
RL Nature 428:522-528(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP GENE ORGANIZATION.
RX PubMed=12730718; DOI=10.1007/s10038-003-0002-x;
RA Iida A., Tanaka T., Nakamura Y.;
RT "High-density SNP map of human ITR, a gene associated with vascular
RT remodeling.";
RL J. Hum. Genet. 48:170-172(2003).
RN [6]
RP VARIANT [LARGE SCALE ANALYSIS] ASN-32.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AK289850; BAF82539.1; -; mRNA.
DR EMBL; AL359708; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471085; EAX08944.1; -; Genomic_DNA.
DR EMBL; BC052243; AAH52243.1; -; mRNA.
DR CCDS; CCDS9472.1; -.
DR RefSeq; NP_851320.1; NM_180989.5.
DR AlphaFoldDB; Q86V85; -.
DR BioGRID; 127770; 22.
DR IntAct; Q86V85; 2.
DR STRING; 9606.ENSP00000366157; -.
DR GlyGen; Q86V85; 3 sites, 1 O-linked glycan (1 site).
DR iPTMnet; Q86V85; -.
DR PhosphoSitePlus; Q86V85; -.
DR SwissPalm; Q86V85; -.
DR BioMuta; GPR180; -.
DR DMDM; 74750449; -.
DR EPD; Q86V85; -.
DR jPOST; Q86V85; -.
DR MassIVE; Q86V85; -.
DR MaxQB; Q86V85; -.
DR PaxDb; Q86V85; -.
DR PeptideAtlas; Q86V85; -.
DR PRIDE; Q86V85; -.
DR ProteomicsDB; 69975; -.
DR Antibodypedia; 53993; 189 antibodies from 28 providers.
DR DNASU; 160897; -.
DR Ensembl; ENST00000376958.5; ENSP00000366157.4; ENSG00000152749.8.
DR GeneID; 160897; -.
DR KEGG; hsa:160897; -.
DR MANE-Select; ENST00000376958.5; ENSP00000366157.4; NM_180989.6; NP_851320.1.
DR UCSC; uc001vly.4; human.
DR CTD; 160897; -.
DR DisGeNET; 160897; -.
DR GeneCards; GPR180; -.
DR HGNC; HGNC:28899; GPR180.
DR HPA; ENSG00000152749; Low tissue specificity.
DR MIM; 607787; gene.
DR neXtProt; NX_Q86V85; -.
DR OpenTargets; ENSG00000152749; -.
DR PharmGKB; PA144596429; -.
DR VEuPathDB; HostDB:ENSG00000152749; -.
DR eggNOG; KOG4290; Eukaryota.
DR GeneTree; ENSGT00940000153981; -.
DR HOGENOM; CLU_040652_0_0_1; -.
DR InParanoid; Q86V85; -.
DR OMA; MTVNHTE; -.
DR OrthoDB; 1543995at2759; -.
DR PhylomeDB; Q86V85; -.
DR TreeFam; TF314975; -.
DR PathwayCommons; Q86V85; -.
DR SignaLink; Q86V85; -.
DR BioGRID-ORCS; 160897; 7 hits in 1075 CRISPR screens.
DR ChiTaRS; GPR180; human.
DR GenomeRNAi; 160897; -.
DR Pharos; Q86V85; Tbio.
DR PRO; PR:Q86V85; -.
DR Proteomes; UP000005640; Chromosome 13.
DR RNAct; Q86V85; protein.
DR Bgee; ENSG00000152749; Expressed in buccal mucosa cell and 153 other tissues.
DR Genevisible; Q86V85; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0019236; P:response to pheromone; IEA:InterPro.
DR InterPro; IPR019336; Intimal_thickness-rel_rcpt.
DR Pfam; PF10192; GpcrRhopsn4; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..440
FT /note="Integral membrane protein GPR180"
FT /id="PRO_0000239662"
FT TRANSMEM 173..193
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 202..222
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 249..269
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 284..304
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 321..341
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 360..380
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 389..409
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 105
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 110
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 32
FT /note="T -> N (in a breast cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035925"
SQ SEQUENCE 440 AA; 49395 MW; CC703269832CF8A3 CRC64;
MGGLRLLAVA LTCCWWPQGS QGKTLRGSFS STAAQDAQGQ RIGHFEFHGD HALLCVRINN
IAVAVGKEAK LYLFQAQEWL KLQQSSHGYS CSEKLSKAQL TMTMNQTEHN LTVSQIPSPQ
TWHVFYADKY TCQDDKENSQ VEDIPFEMVL LNPDAEGNPF DHFSAGESGL HEFFFLLVLV
YFVIACIYAQ SLWQAIKKGG PMHMILKVLT TALLLQAGSA LANYIHFSSY SKDGIGVPFM
GSLAEFFDIA SQIQMLYLLL SLCMGWTIVR MKKSQSRPLQ WDSTPASTGI AVFIVMTQSV
LLLWEQFEDI SHHSYHSHHN LAGILLIVLR ICLALSLGCG LYQIITVERS TLKREFYITF
AKGCILWFLC HPVLACISVI FSDYQRDKVI TIGVILCQSV SMVILYRLFL SHSLYWEVSS
LSSVTLPLTI SSGHKSRPHF
