GP180_MOUSE
ID GP180_MOUSE Reviewed; 441 AA.
AC Q8BPS4; Q9JJG1;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Integral membrane protein GPR180;
DE Flags: Precursor;
GN Name=Gpr180; ORFNames=MNCb-3029;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RA Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.;
RT "Isolation of full-length cDNA clones from mouse brain cDNA library made by
RT oligo-capping method.";
RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Eye;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, Liver, Lung, Pancreas, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AB041545; BAA95030.1; -; mRNA.
DR EMBL; AK053422; BAC35382.1; -; mRNA.
DR EMBL; AK169908; BAE41450.1; -; mRNA.
DR EMBL; BC069981; AAH69981.1; -; mRNA.
DR CCDS; CCDS27333.1; -.
DR RefSeq; NP_067409.2; NM_021434.5.
DR AlphaFoldDB; Q8BPS4; -.
DR STRING; 10090.ENSMUSP00000022728; -.
DR GlyGen; Q8BPS4; 1 site.
DR iPTMnet; Q8BPS4; -.
DR PhosphoSitePlus; Q8BPS4; -.
DR EPD; Q8BPS4; -.
DR MaxQB; Q8BPS4; -.
DR PaxDb; Q8BPS4; -.
DR PeptideAtlas; Q8BPS4; -.
DR PRIDE; Q8BPS4; -.
DR ProteomicsDB; 267750; -.
DR Antibodypedia; 53993; 189 antibodies from 28 providers.
DR DNASU; 58245; -.
DR Ensembl; ENSMUST00000022728; ENSMUSP00000022728; ENSMUSG00000022131.
DR GeneID; 58245; -.
DR KEGG; mmu:58245; -.
DR UCSC; uc007uyq.2; mouse.
DR CTD; 160897; -.
DR MGI; MGI:1930949; Gpr180.
DR VEuPathDB; HostDB:ENSMUSG00000022131; -.
DR eggNOG; KOG4290; Eukaryota.
DR GeneTree; ENSGT00940000153981; -.
DR HOGENOM; CLU_040652_0_0_1; -.
DR InParanoid; Q8BPS4; -.
DR OMA; MTVNHTE; -.
DR OrthoDB; 1543995at2759; -.
DR PhylomeDB; Q8BPS4; -.
DR TreeFam; TF314975; -.
DR BioGRID-ORCS; 58245; 0 hits in 73 CRISPR screens.
DR ChiTaRS; Gpr180; mouse.
DR PRO; PR:Q8BPS4; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q8BPS4; protein.
DR Bgee; ENSMUSG00000022131; Expressed in humerus cartilage element and 242 other tissues.
DR Genevisible; Q8BPS4; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0019236; P:response to pheromone; IEA:InterPro.
DR InterPro; IPR019336; Intimal_thickness-rel_rcpt.
DR Pfam; PF10192; GpcrRhopsn4; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..441
FT /note="Integral membrane protein GPR180"
FT /id="PRO_0000239663"
FT TRANSMEM 174..194
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..226
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 250..270
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 285..305
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 322..342
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 361..381
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 390..410
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 111
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 420
FT /note="S -> P (in Ref. 1; BAA95030)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 441 AA; 48975 MW; 4FEFB71F60063ED9 CRC64;
MGGLRLLAVA LTCSCWWPQG GQGKTLRGSF SSAAARDAQG QSIGHFEFHG DHALLCVRIN
NVAVAVGKEA KLYLFQAQEW LKLLESSPGY SCSERLARAQ LTVTVTQTEH NLTVSQLPAP
QTWRVFYADK FTCRDDSESP QGEEIPFEMV LLNPDAEGNP LDHFSARESG LHEFFFLLVL
VYFVTACIYA QSLWQAMKKG GPMHTILKVL TTALLLQAAS ALANYIHLSR YSRDGLGVPL
IGSLAEVFDI ASQIQMLYLL LSLCMGWTIV RMKKSQSRPL QWDSTPASTG IAVFIVITQS
ILLLWEQFED TSHHSAHSHR SLAGLLLIVL RICLALSLGC GLYQVITVER SALKREFYIT
FAKGCILWFL CQPALACIAV AFNDYQRDKL ITVGVILCQA VAMVILYRLF LSHSLYWEVS
SLSSVTLPLT ISSAHRGRPH F
