ID   GP180_XENLA             Reviewed;         435 AA.
AC   Q5FWM8;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 45.
DE   RecName: Full=Integral membrane protein GPR180;
DE   Flags: Precursor;
GN   Name=gpr180;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; BC089278; AAH89278.1; -; mRNA.
DR   RefSeq; NP_001089985.1; NM_001096516.1.
DR   AlphaFoldDB; Q5FWM8; -.
DR   DNASU; 735056; -.
DR   GeneID; 735056; -.
DR   KEGG; xla:735056; -.
DR   CTD; 735056; -.
DR   Xenbase; XB-GENE-1007252; gpr180.S.
DR   OMA; SIECLAC; -.
DR   OrthoDB; 1543995at2759; -.
DR   Proteomes; UP000186698; Chromosome 2S.
DR   Bgee; 735056; Expressed in liver and 19 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0019236; P:response to pheromone; IEA:InterPro.
DR   InterPro; IPR019336; Intimal_thickness-rel_rcpt.
DR   Pfam; PF10192; GpcrRhopsn4; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..435
FT                   /note="Integral membrane protein GPR180"
FT                   /id="PRO_0000239664"
FT   TRANSMEM        168..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        200..220
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        244..264
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        282..302
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        320..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        355..375
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        384..404
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        100
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        105
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   435 AA;  49094 MW;  96ACFF9C3337193C CRC64;
     MLWSLFVVLQ LVHTGRARTV HGSLDSDVAW HGRGQHIVTF LFHGDQAVLR VKINNVAAAA
     GKESALYLYQ DEQWVQIHSS LEEYSCPERL SLAQDTIPLN QTEYNYTLPQ MAYPKAWYVI
     YVDKFTCLVK YEDQKSDAIT FEVAMLNPDA AGNPFDHFGA DESGLHEFFF LLVLIYFVAA
     CIYIQALWQM MKKGGPMHTV LKVLSTALLL QVVSALANYL HLSRYATDGK GAPLVGSLAE
     LCDIASEVQM LYLLLSLCMG WTLSRKKKSQ GKPLQWDRTP ASTGIAVLAV SAQVILLVWE
     LFEDANHHSF HAHQSLAENL LIAMKICLAI SLACGLYQII TVERSTMKRQ FYITFAKGCF
     LWFLCHPCFV AISFLFKEYQ REKVITVGVI VSQSVSMIIL YRLFLSHSLY WEVSSLSSVT
     LPLTVSSGHR SRYYS