GP182_HUMAN
ID GP182_HUMAN Reviewed; 404 AA.
AC O15218;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=G-protein coupled receptor 182;
GN Name=GPR182; Synonyms=ADMR;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=9367907; DOI=10.1006/bbrc.1997.7631;
RA Haenze J., Dittrich K., Dotsch J., Rascher W.;
RT "Molecular cloning of a novel human receptor gene with homology to the rat
RT adrenomedullin receptor and high expression in heart and immune system.";
RL Biochem. Biophys. Res. Commun. 240:183-188(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Kopatz S.A., Aronstam R.S., Sharma S.V.;
RT "cDNA clones of human proteins involved in signal transduction sequenced by
RT the Guthrie cDNA resource center (www.cdna.org).";
RL Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP DOUBTS ON THE ORIGINAL FUNCTION.
RX PubMed=9535752; DOI=10.1006/bbrc.1998.8349;
RA Kennedy S.P., Sun D., Oleynek J.J., Hoth C.F., Kong J., Hill R.J.;
RT "Expression of the rat adrenomedullin receptor or a putative human
RT adrenomedullin receptor does not correlate with adrenomedullin binding or
RT functional response.";
RL Biochem. Biophys. Res. Commun. 244:832-837(1998).
CC -!- FUNCTION: Orphan receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Highly expressed in heart, skeletal muscle, immune
CC system, adrenal gland and liver. {ECO:0000269|PubMed:9367907}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: Was originally thought to be a receptor for adrenomedullin.
CC {ECO:0000305|PubMed:9367907}.
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DR EMBL; Y13583; CAA73910.1; -; mRNA.
DR EMBL; AY268434; AAP23201.1; -; Genomic_DNA.
DR EMBL; BC034761; AAH34761.1; -; mRNA.
DR CCDS; CCDS8927.1; -.
DR PIR; JC5784; JC5784.
DR RefSeq; NP_009195.1; NM_007264.3.
DR RefSeq; XP_011536126.1; XM_011537824.2.
DR RefSeq; XP_011536127.1; XM_011537825.2.
DR RefSeq; XP_011536129.1; XM_011537827.2.
DR AlphaFoldDB; O15218; -.
DR SMR; O15218; -.
DR BioGRID; 116449; 502.
DR IntAct; O15218; 11.
DR MINT; O15218; -.
DR STRING; 9606.ENSP00000300098; -.
DR ChEMBL; CHEMBL4356; -.
DR GlyGen; O15218; 2 sites.
DR PhosphoSitePlus; O15218; -.
DR BioMuta; GPR182; -.
DR MassIVE; O15218; -.
DR PaxDb; O15218; -.
DR PeptideAtlas; O15218; -.
DR PRIDE; O15218; -.
DR ProteomicsDB; 48515; -.
DR Antibodypedia; 16024; 307 antibodies from 32 providers.
DR DNASU; 11318; -.
DR Ensembl; ENST00000300098.3; ENSP00000300098.1; ENSG00000166856.3.
DR GeneID; 11318; -.
DR KEGG; hsa:11318; -.
DR MANE-Select; ENST00000300098.3; ENSP00000300098.1; NM_007264.4; NP_009195.1.
DR UCSC; uc001smk.4; human.
DR CTD; 11318; -.
DR DisGeNET; 11318; -.
DR GeneCards; GPR182; -.
DR HGNC; HGNC:13708; GPR182.
DR HPA; ENSG00000166856; Tissue enhanced (lymphoid tissue, testis).
DR MIM; 605307; gene.
DR neXtProt; NX_O15218; -.
DR OpenTargets; ENSG00000166856; -.
DR PharmGKB; PA162390165; -.
DR VEuPathDB; HostDB:ENSG00000166856; -.
DR eggNOG; ENOG502QSNU; Eukaryota.
DR GeneTree; ENSGT00940000154307; -.
DR HOGENOM; CLU_009579_8_3_1; -.
DR InParanoid; O15218; -.
DR OMA; LCRFTHY; -.
DR OrthoDB; 846926at2759; -.
DR PhylomeDB; O15218; -.
DR TreeFam; TF333489; -.
DR PathwayCommons; O15218; -.
DR SignaLink; O15218; -.
DR BioGRID-ORCS; 11318; 12 hits in 1069 CRISPR screens.
DR GeneWiki; GPR182; -.
DR GenomeRNAi; 11318; -.
DR Pharos; O15218; Tbio.
DR PRO; PR:O15218; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; O15218; protein.
DR Bgee; ENSG00000166856; Expressed in spleen and 96 other tissues.
DR ExpressionAtlas; O15218; baseline and differential.
DR Genevisible; O15218; HS.
DR GO; GO:0016021; C:integral component of membrane; TAS:ProtInc.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; TAS:ProtInc.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; TAS:ProtInc.
DR InterPro; IPR001350; G10D_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00643; G10DORPHANR.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..404
FT /note="G-protein coupled receptor 182"
FT /id="PRO_0000069112"
FT TOPO_DOM 1..57
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..90
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 91..113
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 114..127
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..149
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 150..170
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..193
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 194..217
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 218..239
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 240..258
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 259..280
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 281..299
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 300..320
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 321..404
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 28
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 37
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 126..202
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 349
FT /note="C -> R (in dbSNP:rs35493121)"
FT /id="VAR_033464"
SQ SEQUENCE 404 AA; 45323 MW; EF187ECFDF2DC6C1 CRC64;
MSVKPSWGPG PSEGVTAVPT SDLGEIHNWT ELLDLFNHTL SECHVELSQS TKRVVLFALY
LAMFVVGLVE NLLVICVNWR GSGRAGLMNL YILNMAIADL GIVLSLPVWM LEVTLDYTWL
WGSFSCRFTH YFYFVNMYSS IFFLVCLSVD RYVTLTSASP SWQRYQHRVR RAMCAGIWVL
SAIIPLPEVV HIQLVEGPEP MCLFMAPFET YSTWALAVAL STTILGFLLP FPLITVFNVL
TACRLRQPGQ PKSRRHCLLL CAYVAVFVMC WLPYHVTLLL LTLHGTHISL HCHLVHLLYF
FYDVIDCFSM LHCVINPILY NFLSPHFRGR LLNAVVHYLP KDQTKAGTCA SSSSCSTQHS
IIITKGDSQP AAAAPHPEPS LSFQAHHLLP NTSPISPTQP LTPS
