GP182_MOUSE
ID GP182_MOUSE Reviewed; 395 AA.
AC P43142;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 25-MAY-2022, entry version 127.
DE RecName: Full=G-protein coupled receptor 182;
DE AltName: Full=G10D;
DE AltName: Full=NOW;
GN Name=Gpr182; Synonyms=Admr, Gpcr22;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ; TISSUE=Brain;
RA Saeki Y., Ueno S., Nagai Y., Yanagihara T.;
RL Submitted (JUN-1993) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 149-262.
RC TISSUE=Testis;
RX PubMed=8288218; DOI=10.1006/geno.1993.1452;
RA Wilkie T.M., Chen Y., Gilbert D.J., Moore K.J., Yu L., Simon M.I.,
RA Copeland N.G., Jenkins N.A.;
RT "Identification, chromosomal location, and genome organization of mammalian
RT G-protein-coupled receptors.";
RL Genomics 18:175-184(1993).
CC -!- FUNCTION: Orphan receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in liver and lung.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; D17292; BAA04125.1; -; mRNA.
DR EMBL; L20338; AAA16849.1; -; mRNA.
DR PIR; I48909; I48909.
DR AlphaFoldDB; P43142; -.
DR SMR; P43142; -.
DR STRING; 10090.ENSMUSP00000100882; -.
DR GlyGen; P43142; 2 sites.
DR iPTMnet; P43142; -.
DR PhosphoSitePlus; P43142; -.
DR MaxQB; P43142; -.
DR PaxDb; P43142; -.
DR PRIDE; P43142; -.
DR ProteomicsDB; 267751; -.
DR MGI; MGI:109545; Gpr182.
DR eggNOG; ENOG502QSNU; Eukaryota.
DR InParanoid; P43142; -.
DR PhylomeDB; P43142; -.
DR PRO; PR:P43142; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; P43142; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001605; F:adrenomedullin receptor activity; ISO:MGI.
DR InterPro; IPR001350; G10D_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00643; G10DORPHANR.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Phosphoprotein; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..395
FT /note="G-protein coupled receptor 182"
FT /id="PRO_0000069113"
FT TOPO_DOM 1..53
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 54..75
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..86
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..109
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 110..123
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..145
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 146..166
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..189
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 190..213
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 214..235
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 236..254
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 255..276
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 277..295
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 296..316
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 317..395
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOD_RES 329
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P31392"
FT CARBOHYD 24
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 33
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 122..198
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 395 AA; 45497 MW; 879EB108982F1710 CRC64;
MSVIPSPRPV STLEPDNDFR DIHNWTELLH LFNQTFTDCH IEFNENTKHV VLFVFYLAIF
VVGLVENVLV ICVNCRRSGR VGMLNLYILN MAIADLGIIL SLPVWMLEVM LEYTWLWGSF
SCRFIHYFYL VNMYSSIFFL TCLSIDRYVT LTNTSPSWQR HQHRIRRAVC AGVWVLSAII
PLPEVVHIQL LDGSEPMCLF LAPFETYSAW ALAVALSATI LGFLLPFLLI AVFNILTACR
LRRQRQTESR RHCLLMWAYI VVFAICWLPY QVTMLLLTLH GTHIFLHCHL VNLLYFFYEI
IDCFSMLHCV ANPILYNFLS PSFRGRLLSL VVRYLPKEQA RAAGGRASSS SSTQHSIIIT
KEGSLPLQRI STPTPSETFR RPLRLQTPHL HSAIL
