ID   GP19_BPLC2              Reviewed;         107 AA.
AC   Q38278;
DT   29-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   23-FEB-2022, entry version 52.
DE   RecName: Full=Gene product 19 {ECO:0000305};
DE            Short=gp19;
DE   AltName: Full=AbiQ resistance protein {ECO:0000305};
DE   AltName: Full=E19 {ECO:0000303|PubMed:23813728};
GN   Name=e19 {ECO:0000303|PubMed:8534101};
OS   Lactococcus phage c2.
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Siphoviridae; Ceduovirus.
OX   NCBI_TaxID=31537;
OH   NCBI_TaxID=1357; Lactococcus (lactic streptococci).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8534101; DOI=10.1128/aem.61.12.4348-4356.1995;
RA   Lubbers M.W., Waterfield N.R., Beresford T.P., Le Page R.W., Jarvis A.W.;
RT   "Sequencing and analysis of the prolate-headed lactococcal bacteriophage c2
RT   genome and identification of the structural genes.";
RL   Appl. Environ. Microbiol. 61:4348-4356(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8221377; DOI=10.1139/m93-113;
RA   Ward L.J., Beresford T.P., Lubbers M.W., Jarvis B.D., Jarvis A.W.;
RT   "Sequence analysis of the lysin gene region of the prolate lactococcal
RT   bacteriophage c2.";
RL   Can. J. Microbiol. 39:767-774(1993).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=7816023; DOI=10.1007/bf00283263;
RA   Lubbers M.W., Ward L.J., Beresford T.P., Jarvis B.D., Jarvis A.W.;
RT   "Sequencing and analysis of the cos region of the lactococcal bacteriophage
RT   c2.";
RL   Mol. Gen. Genet. 245:160-166(1994).
RN   [4]
RP   FUNCTION, VARIANT ASP-17, AND CHARACTERIZATION OF VARIANT ASP-17.
RX   PubMed=23813728; DOI=10.1128/jb.00296-13;
RA   Samson J.E., Belanger M., Moineau S.;
RT   "Effect of the abortive infection mechanism and type III toxin/antitoxin
RT   system AbiQ on the lytic cycle of Lactococcus lactis phages.";
RL   J. Bacteriol. 195:3947-3956(2013).
CC   -!- FUNCTION: Seems to be involved in escape from killing mediated by the
CC       bacterial type III toxin-antitoxin module AbiQ toxin protein upon
CC       infection of L.lactis subsp. lactis strain IL1403. A single variant
CC       independently isolated from 5 different phage confers on the virus the
CC       ability to partially escape killing (i.e. the virus grows in the
CC       bacteria). {ECO:0000305|PubMed:23813728}.
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DR   EMBL; L48605; AAA92161.1; -; Genomic_DNA.
DR   RefSeq; NP_043530.1; NC_001706.1.
DR   GeneID; 1261171; -.
DR   KEGG; vg:1261171; -.
DR   Proteomes; UP000001835; Genome.
PE   1: Evidence at protein level;
KW   Early protein; Reference proteome.
FT   CHAIN           1..107
FT                   /note="Gene product 19"
FT                   /id="PRO_0000432939"
FT   VARIANT         17
FT                   /note="E -> D (in c2-Q3; confers partial resistance to
FT                   bacterial AbiQ)"
FT                   /evidence="ECO:0000269|PubMed:23813728"
SQ   SEQUENCE   107 AA;  12503 MW;  92361F194512BCDE CRC64;
     MINLQNKKLD IKEFLQELGF TVSLDYEREP MGVMFAEIHP IVSQVSNNSA IYQSFRTLEI
     ELMVICTEET ENSLYRAVQL LSDEHYIYAN TITDNTNIIK LRGNYYD