GP1D_CHLTH
ID GP1D_CHLTH Reviewed; 451 AA.
AC P0CE16; P08781; P10555; P22445;
DT 02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 02-MAR-2010, sequence version 1.
DT 03-AUG-2022, entry version 53.
DE RecName: Full=Probable plasmid replicative DNA helicase;
DE EC=3.6.4.12;
DE AltName: Full=DnaB-like protein;
DE AltName: Full=Protein P-3;
DE AltName: Full=Virulence plasmid protein pGP1-D;
OS Chlamydia trachomatis.
OG Plasmid pLGV440, Plasmid pCHL1, and Plasmid pCTT1.
OC Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC Chlamydia/Chlamydophila group; Chlamydia.
OX NCBI_TaxID=813;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=L1/440/LN; PLASMID=pLGV440;
RX PubMed=2836808; DOI=10.1093/nar/16.9.4053;
RA Hatt C., Ward M.E., Clarke I.N.;
RT "Analysis of the entire nucleotide sequence of the cryptic plasmid of
RT Chlamydia trachomatis serovar L1. Evidence for involvement in DNA
RT replication.";
RL Nucleic Acids Res. 16:4053-4067(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=D/GO/86; PLASMID=pCHL1;
RX PubMed=2194229; DOI=10.1016/0147-619x(90)90034-a;
RA Comanducci M., Ricci S., Cevenini R., Ratti G.;
RT "Diversity of the Chlamydia trachomatis common plasmid in biovars with
RT different pathogenicity.";
RL Plasmid 23:149-154(1990).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Serotype B; PLASMID=pCTT1;
RX PubMed=3444859; DOI=10.1016/0147-619x(87)90063-1;
RA Sriprakash K.S., Macavoy E.S.;
RT "Characterization and sequence of a plasmid from the trachoma biovar of
RT Chlamydia trachomatis.";
RL Plasmid 18:205-214(1987).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-407.
RC STRAIN=Serotype B; PLASMID=pCTT1;
RX PubMed=2827127; DOI=10.1093/nar/15.24.10596;
RA Sriprakash K.S., Macavoy E.S.;
RT "A gene for dnaB like protein in chlamydial plasmid.";
RL Nucleic Acids Res. 15:10596-10596(1987).
CC -!- FUNCTION: Required for growth within mammalian cells.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC -!- SIMILARITY: Belongs to the helicase family. DnaB subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB02586.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=CAA68558.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; X06707; CAA29892.1; -; Genomic_DNA.
DR EMBL; J03321; AAA91569.1; -; Genomic_DNA.
DR EMBL; M19487; AAB02586.1; ALT_FRAME; Genomic_DNA.
DR EMBL; Y00505; CAA68558.1; ALT_FRAME; Genomic_DNA.
DR PIR; A37386; A37386.
DR PIR; S01921; S01921.
DR PIR; S06324; S06324.
DR RefSeq; NP_040382.1; NC_001372.1.
DR RefSeq; WP_010889884.1; NC_001372.1.
DR RefSeq; WP_012209814.1; NZ_CP054433.1.
DR RefSeq; YP_001569036.1; NC_010029.2.
DR RefSeq; YP_001654084.1; NC_010286.1.
DR AlphaFoldDB; P0CE16; -.
DR SMR; P0CE16; -.
DR OMA; YPSIDEH; -.
DR GO; GO:1990077; C:primosome complex; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0006269; P:DNA replication, synthesis of RNA primer; IEA:UniProtKB-KW.
DR CDD; cd00984; DnaB_C; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR036185; DNA_heli_DnaB-like_N_sf.
DR InterPro; IPR007694; DNA_helicase_DnaB-like_C.
DR InterPro; IPR007693; DNA_helicase_DnaB-like_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00772; DnaB; 1.
DR Pfam; PF03796; DnaB_C; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF48024; SSF48024; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51199; SF4_HELICASE; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA replication; DNA-binding; Helicase; Hydrolase;
KW Nucleotide-binding; Plasmid; Primosome.
FT CHAIN 1..451
FT /note="Probable plasmid replicative DNA helicase"
FT /id="PRO_0000102038"
FT DOMAIN 194..451
FT /note="SF4 helicase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00596"
FT BINDING 225..232
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00596"
FT VARIANT 55
FT /note="Y -> H (in plasmid pCHL1)"
FT VARIANT 188
FT /note="A -> V (in plasmid pCHL1)"
FT VARIANT 189
FT /note="T -> A (in plasmid pCHL1 and plasmid pCTT1)"
FT VARIANT 200
FT /note="A -> G (in plasmid pCHL1 and plasmid pCTT1)"
FT VARIANT 267
FT /note="I -> V (in plasmid pCTT1)"
SQ SEQUENCE 451 AA; 51457 MW; 2CD73A152C72A1F1 CRC64;
MKTRSEIENR MQDIEYALLG KALIFEDSTE YILRQLANYE FKCSHHKNIF IVFKYLKDNG
LPITVDSAWE ELLRRRIKDM DKSYLGLMLH DALSNDKLRS VSHTVFLDDL SVCSAEENLS
NFIFRSFNEY NENPLRRSPF LLLERIKGRL DSAIAKTFSI RSARGRSIYD IFSQSEIGVL
ARIKKRRATF SENQNSFFDA FPTGYKDIDD KGVILAKGNF VIIAARPSIG KTALAIDMAI
NLAVTQQRRV GFLSLEMSAG QIVERIIANL TGISGEKLQR GDLSKEELFR VEEAGETVRE
SHFYICSDSQ YKLNLIANQI RLLRKEDRVD VIFIDYLQLI NSSVGENRQN EIADISRTLR
GLASELNIPI VCLSQLSRKV EDRANKVPML SDLRDSGQIE QDADVILFIN RKESSSNCEI
TVGKNRHGSV FSSVLHFDPK ISKFSAIKKV W
