GP210_ARATH
ID GP210_ARATH Reviewed; 1923 AA.
AC F4KHD8; Q9FI62;
DT 26-NOV-2014, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 25-MAY-2022, entry version 66.
DE RecName: Full=Nuclear pore complex protein GP210 {ECO:0000303|PubMed:21189294};
DE AltName: Full=Nuclear pore membrane glycoprotein 210 {ECO:0000250|UniProtKB:Q8TEM1};
DE AltName: Full=Nucleoporin GP210;
DE AltName: Full=Protein EMBRYO DEFECTIVE 3012 {ECO:0000312|EMBL:AED94552.1};
DE Flags: Precursor;
GN Name=GB210 {ECO:0000303|PubMed:21189294};
GN Synonyms=EMB3012 {ECO:0000312|EMBL:AED94552.1};
GN OrderedLocusNames=At5g40480 {ECO:0000312|Araport:AT5G40480};
GN ORFNames=K21I16.30 {ECO:0000312|EMBL:BAB10497.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|Proteomes:UP000006548};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10470850; DOI=10.1093/dnares/6.3.183;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Kotani H.,
RA Miyajima N., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. IX. Sequence
RT features of the regions of 1,011,550 bp covered by seventeen P1 and TAC
RT clones.";
RL DNA Res. 6:183-195(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP IDENTIFICATION IN THE NUCLEAR PORE COMPLEX BY MASS SPECTROMETRY,
RP SUBCELLULAR LOCATION, AND NOMENCLATURE.
RX PubMed=21189294; DOI=10.1105/tpc.110.079947;
RA Tamura K., Fukao Y., Iwamoto M., Haraguchi T., Hara-Nishimura I.;
RT "Identification and characterization of nuclear pore complex components in
RT Arabidopsis thaliana.";
RL Plant Cell 22:4084-4097(2010).
CC -!- SUBUNIT: Part of the nuclear pore complex (NPC). The NPC has an eight-
CC fold symmetrical structure comprising a central transport channel and
CC two rings, the cytoplasmic and nuclear rings, to which eight filaments
CC are attached. The cytoplasmic filaments have loose ends, while the
CC nuclear filaments are joined in a distal ring, forming a nuclear
CC basket. NPCs are highly dynamic in configuration and composition, and
CC can be devided in 3 subcomplexes, the NUP62 subcomplex, the NUP107-160
CC subcomplex and the NUP93 subcomplex, containing approximately 30
CC different nucleoporin proteins. {ECO:0000305|PubMed:21189294}.
CC -!- SUBCELLULAR LOCATION: Nucleus envelope {ECO:0000269|PubMed:21189294}.
CC Nucleus membrane {ECO:0000255}; Single-pass membrane protein
CC {ECO:0000255}. Nucleus, nuclear pore complex
CC {ECO:0000305|PubMed:21189294}.
CC -!- SIMILARITY: Belongs to the NUP210 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB10497.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB017062; BAB10497.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED94552.1; -; Genomic_DNA.
DR RefSeq; NP_198864.2; NM_123412.4.
DR AlphaFoldDB; F4KHD8; -.
DR BioGRID; 19297; 5.
DR STRING; 3702.AT5G40480.1; -.
DR iPTMnet; F4KHD8; -.
DR PaxDb; F4KHD8; -.
DR PRIDE; F4KHD8; -.
DR ProteomicsDB; 248457; -.
DR EnsemblPlants; AT5G40480.1; AT5G40480.1; AT5G40480.
DR GeneID; 834046; -.
DR Gramene; AT5G40480.1; AT5G40480.1; AT5G40480.
DR KEGG; ath:AT5G40480; -.
DR Araport; AT5G40480; -.
DR TAIR; locus:2155652; AT5G40480.
DR eggNOG; KOG1833; Eukaryota.
DR HOGENOM; CLU_001205_1_1_1; -.
DR InParanoid; F4KHD8; -.
DR OMA; AELHIRE; -.
DR OrthoDB; 843414at2759; -.
DR PRO; PR:F4KHD8; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; F4KHD8; baseline and differential.
DR Genevisible; F4KHD8; AT.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:TAIR.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005635; C:nuclear envelope; IDA:TAIR.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR003343; Big_2.
DR InterPro; IPR008964; Invasin/intimin_cell_adhesion.
DR InterPro; IPR045197; NUP210-like.
DR PANTHER; PTHR23019; PTHR23019; 1.
DR SMART; SM00635; BID_2; 3.
DR SUPFAM; SSF49373; SSF49373; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; mRNA transport; Nuclear pore complex; Nucleus;
KW Protein transport; Reference proteome; Signal; Translocation;
KW Transmembrane; Transmembrane helix; Transport.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..1923
FT /note="Nuclear pore complex protein GP210"
FT /id="PRO_0000431090"
FT TRANSMEM 1829..1849
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 1152..1205
FT /note="BIG2"
FT /evidence="ECO:0000255"
FT CARBOHYD 73
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 117
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 289
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 609
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 863
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 903
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 967
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 982
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 1171
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 1199
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 1550
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 1568
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 1743
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 1923 AA; 210666 MW; CF0A2FABD98D8870 CRC64;
MVPVSFCFFF LLLLLSAGES SSQLVSGPHI TDVNILLPPK MKNPVEYRLQ GSDGCFKWSW
DHHDILSVTP EFNSSSHCST SARLRSISPY SGRKETAVYA TDIQTGMVIR CKVFIDNFSR
IQIFHNSIKL DLDGLSMLRV RAFDNEDNEF SSLVGLQFIW KLMPESGGST HHLAHVPLKE
SPLTDCGGLC GYLDIQKKLE DSGVFADLFV VKGTKIGHEK VSVHLLEAPL THIADEIVLT
VAEAMSLEPR SPVYVLMGAS FGYTLKVMRG NVPQAVDLPS PHHRWSVLNS SVAQVDSLIG
LTKALSLGVT TVVVEDTRVA GHIQGSSINV VTPDTLILYI SPWSMSGDLI TESKPFPSSM
HWYVVSGRQY LIQMKIFSGR PDAHEIYITE TDDIKLYGKD SDYWKIVSLP DELSSEYGQR
NSRILNAISP GLGELTSTLT YFSGHQESKE VLKVVQEIRV CEKVQFTLNS EDDTPKVLLP
WTPAVYQEME LIVTGGCAKA SSDYKWFTSD ISILSVSAYG IIQAKRPGIA TVKVVSTFDS
QNFDEVIVEV SIPSSMVMLQ NFPVETVVGS HLKAAVTMKA LNGATFSRCD AFNSLIKWKT
GSESFVIVNA TSEMMMLDEL RSMDSSPPCS RASIYTASTG RTVLQATLAK EFHYFDKSLS
ESIDLKATLT IGAYLPLSVR QDSDGNHHGG YWFDKAQEET DFGVSKLYLV PGTYVDVMLL
GGPERWDDNV EFTETVKTLY EDEEDLTSRV NVHHEVDRRA NMYRISCQKL GSYKLVFLRG
NLLGIDHPVP AVAEALLSVH CSLPSSVVLI VDEPVNKLDV IRAASQADRA PGRLRVTPVT
VANGQIIRVA AVGISEFGEA FSNSSTLSLR WELTSCNNLA YWDDDYNSKM TKSGWERFLA
LRNESGLCTV RATVSGIDYS FKSQYSTLLP QGSESTLTDA VRLQLVSTLR VTPEFNLVFF
NPNAKVNLSM TGGSCLWEAV VNNSRVAEVI RPPSGLQCSQ MMLSPKGLGT TIVTVYDIGV
SPPLSALALI KVADVDWIKI ASGDEISIME GSTHSIDLLT GIDDGMTFDS SQYSLMDIMV
HIEDDLVEHV TVDEDSLSVG EHVATSSFKI AARRLGITTL YVSARQQSGG KVLSQTIKVE
VYSPPRLHPQ GIFLVPGASY VLTIEGGPTM NVSVDYTTVD NEVAKIEKSG RLYATSPGNT
TIYATIYGSE GAVICQAIGN AEVGLPATAM LVAQSDTVAV GHEMPVSPSF PEGDLLSFYE
LCSAYKWTIE DEKVLIFIAS SINVEENAGF VNVVQGRSAG KTRVTIAFSC DFVSPGLYSE
SRTYEASMIL SVVPDLPLSL GAPMTWVLPP FYTSSGLLPS SSEPQKHRDG QSHRGNIVYS
ILKDCSSRAD FERDTISING GSVKTTDSNN VACIQAKDRT SGRIEIAACV RVAEVAQIRM
KSEGIPFHVI DLAVGGELEL PINYYDTLGI PFLEAHGVTT YNVETNHRDV VFIKTVNDQP
SAYIKGIKHG KALIRVSIGD NLRKSDYVLV SVGAHIFPQN PVIHTGNLLN FSITGADNEV
TGQWFTSNRS VISVNVASGQ AKAISQGSTH VTFKGHGLKL QTKVTVLFGN TIYVDSPGET
LTNVHVPAEG YKFPVKFREN KFAVTEHGNK ATFNCQVDPP FIGYTKPWMD LDTGNTYCLF
FPYSPEHLVH SMSITKDMKP HVSFSVDASL KEARRVSGSA SALLIGGFSV TGPDKLNINP
DSNTTIISLV GNTDVQIHCR NKGRLSISLI KRDDFGIAGH AQYKVNVLRS EQFTDRIIIT
LPATGQIVEI DVCYDTGESL VASSKDGYSV LLKILWGVLV LVVSVIILMK VIDRQVPTGA
TGTATYSGNA AQGTPERRSG TVIYHEESPR TPSPFMEYVK RTVDETPYYR REGRRRFNPQ
NTM
