ID   GP22_LITCA              Reviewed;         148 AA.
AC   Q01493;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=Major microfilarial sheath protein;
DE   Flags: Precursor;
GN   Name=GP22;
OS   Litomosoides carinii.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Litomosoides.
OX   NCBI_TaxID=6299;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1446819; DOI=10.1016/0378-1119(92)90125-9;
RA   Christ H., Hirzmann J., Conraths F., Zahner H., Stirm S., Hobom G.;
RT   "Trans-splicing of an early embryo mRNA in Litomosoides carinii, coding for
RT   the major microfilarial sheath protein gp22.";
RL   Gene 121:219-226(1992).
RN   [2]
RP   PROTEIN SEQUENCE OF 44-80.
RX   PubMed=1780176; DOI=10.1017/s0031182000059904;
RA   Bardehle G., Conraths F.J., Fahrenholz F., Hintz M., Linder D., Schares G.,
RA   Schott H.-H., Schuetzle B., Stirm S., Stueber W., Zahner H.;
RT   "A major Litomosoides carinii microfilarial sheath glycoprotein (gp22):
RT   amino terminal sequence and immunological studies with corresponding
RT   synthetic peptides.";
RL   Parasitology 103:387-394(1991).
CC   -!- DEVELOPMENTAL STAGE: Is synthesized at high levels at a very early
CC       stage of embryonic intrauterine development and becomes a major
CC       constituent of the primary egg shell.
CC   -!- PTM: O-glycosylated. {ECO:0000305}.
CC   -!- SIMILARITY: To B.pahangi filarial sheath protein. {ECO:0000305}.
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DR   EMBL; M96232; AAA29278.1; -; Genomic_DNA.
DR   PIR; JH0788; JH0788.
DR   AlphaFoldDB; Q01493; -.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Glycoprotein; Repeat; Signal.
FT   SIGNAL          1..18
FT   PROPEP          19..43
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000269|PubMed:1780176"
FT                   /id="PRO_0000021349"
FT   CHAIN           44..148
FT                   /note="Major microfilarial sheath protein"
FT                   /id="PRO_0000021350"
FT   REPEAT          46..50
FT   REPEAT          54..58
FT   REPEAT          59..63
FT   REPEAT          64..68
FT   REPEAT          71..75
FT   REGION          46..75
FT                   /note="Repeat-rich region"
FT   REGION          52..80
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        52..75
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   148 AA;  16118 MW;  5CED50DFA0A7EAED CRC64;
     MCCKAILSFC ILSSLGNALY FGSHRPQYLR EVGQRQYPFE PQAFGMLPVP QQPMGPQPMG
     PQPMEPQPLP MGPQSPQMQV PDRSCSGCVI NINCGGRECL PTRPTQTQPT QPSWTVETPP
     TPTPGASQGC RVCACYVPPP CQICQPCQ