ID   GP26_BPT4               Reviewed;         208 AA.
AC   P13335;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 2.
DT   29-SEP-2021, entry version 87.
DE   RecName: Full=Baseplate hub assembly protein gp26 {ECO:0000303|PubMed:21129200};
DE   AltName: Full=Gene product 26;
DE            Short=gp26;
DE   AltName: Full=Hub protein 26;
DE   Flags: Precursor;
GN   Name=26;
OS   Enterobacteria phage T4 (Bacteriophage T4).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Myoviridae; Tevenvirinae; Tequatrovirus.
OX   NCBI_TaxID=10665;
OH   NCBI_TaxID=562; Escherichia coli.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2186370; DOI=10.1093/nar/18.7.1913;
RA   Nivinskas R., Raudonikiene A., Vaiskunaite R.;
RT   "Bacteriophage T4 gene 26.";
RL   Nucleic Acids Res. 18:1913-1913(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12626685; DOI=10.1128/mmbr.67.1.86-156.2003;
RA   Miller E.S., Kutter E., Mosig G., Arisaka F., Kunisawa T., Ruger W.;
RT   "Bacteriophage T4 genome.";
RL   Microbiol. Mol. Biol. Rev. 67:86-156(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 116-208.
RC   STRAIN=D;
RX   PubMed=3186452; DOI=10.1093/nar/16.20.9862;
RA   Gruidl M.E., Canan N., Mosig G.;
RT   "Bacteriophage T4 gene 25.";
RL   Nucleic Acids Res. 16:9862-9862(1988).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-26.
RC   STRAIN=D;
RX   PubMed=2763463; DOI=10.1016/0042-6822(89)90617-x;
RA   Scarlato V., Storlazzi A., Gargano S., Cascino A.;
RT   "Bacteriophage T4 late gene expression: overlapping promoters direct
RT   divergent transcription of the base plate gene cluster.";
RL   Virology 171:475-483(1989).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 130-208.
RX   PubMed=1871975; DOI=10.1016/0042-6822(91)90852-3;
RA   Gruidl M.E., Chen T.C., Gargano S., Storlazzi A., Cascino A., Mosig G.;
RT   "Two bacteriophage T4 base plate genes (25 and 26) and the DNA repair gene
RT   uvsY belong to spatially and temporally overlapping transcription units.";
RL   Virology 184:359-369(1991).
RN   [6]
RP   PROTEIN SEQUENCE OF 6-16, AND SUBCELLULAR LOCATION.
RX   PubMed=15342608; DOI=10.1128/jb.186.18.6335-6339.2004;
RA   Ye N., Nemoto N.;
RT   "Processing of the tail lysozyme (gp5) of bacteriophage T4.";
RL   J. Bacteriol. 186:6335-6339(2004).
RN   [7]
RP   FUNCTION.
RX   PubMed=6387173; DOI=10.1128/jvi.52.2.344-349.1984;
RA   Kozloff L.M., Lute M.;
RT   "Identification of bacteriophage T4D gene products 26 and 51 as baseplate
RT   hub structural components.";
RL   J. Virol. 52:344-349(1984).
RN   [8]
RP   FUNCTION.
RX   PubMed=2403438; DOI=10.1128/jvi.64.1.143-154.1990;
RA   Watts N.R., Coombs D.H.;
RT   "Structure of the bacteriophage T4 baseplate as determined by chemical
RT   cross-linking.";
RL   J. Virol. 64:143-154(1990).
RN   [9]
RP   REVIEW ON FUNCTION.
RX   PubMed=14625682; DOI=10.1007/s00018-003-3072-1;
RA   Leiman P.G., Kanamaru S., Mesyanzhinov V.V., Arisaka F., Rossmann M.G.;
RT   "Structure and morphogenesis of bacteriophage T4.";
RL   Cell. Mol. Life Sci. 60:2356-2370(2003).
RN   [10]
RP   REVIEW ON FUNCTION.
RX   PubMed=21129200; DOI=10.1186/1743-422x-7-355;
RA   Leiman P.G., Arisaka F., van Raaij M.J., Kostyuchenko V.A., Aksyuk A.A.,
RA   Kanamaru S., Rossmann M.G.;
RT   "Morphogenesis of the T4 tail and tail fibers.";
RL   Virol. J. 7:355-355(2010).
RN   [11]
RP   FUNCTION.
RX   PubMed=27193680; DOI=10.1038/nature17971;
RA   Taylor N.M., Prokhorov N.S., Guerrero-Ferreira R.C., Shneider M.M.,
RA   Browning C., Goldie K.N., Stahlberg H., Leiman P.G.;
RT   "Structure of the T4 baseplate and its function in triggering sheath
RT   contraction.";
RL   Nature 533:346-352(2016).
CC   -!- FUNCTION: Baseplate hub assembly chaperone involved in the tail
CC       assembly. {ECO:0000303|PubMed:21129200, ECO:0000305|PubMed:2403438,
CC       ECO:0000305|PubMed:27193680, ECO:0000305|PubMed:6387173}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000269|PubMed:15342608}.
CC       Note=Present in the baseplate. {ECO:0000269|PubMed:15342608}.
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DR   EMBL; X17685; CAA35676.1; -; Genomic_DNA.
DR   EMBL; AF158101; AAD42434.1; -; Genomic_DNA.
DR   EMBL; J04354; AAA88464.1; -; Genomic_DNA.
DR   EMBL; M77695; AAA32548.1; -; Genomic_DNA.
DR   PIR; JF0055; JF0055.
DR   PIR; JQ0441; GXBPT4.
DR   RefSeq; NP_049801.1; NC_000866.4.
DR   TCDB; 1.K.1.1.1; the gp27/5 t4-baseplate (t4-bp) family.
DR   GeneID; 1258552; -.
DR   KEGG; vg:1258552; -.
DR   Proteomes; UP000009087; Genome.
DR   GO; GO:0098003; P:viral tail assembly; IEA:UniProtKB-KW.
DR   InterPro; IPR024364; Baseplate_phage_T4-like.
DR   Pfam; PF12322; T4_baseplate; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Late protein; Reference proteome;
KW   Viral release from host cell; Viral tail assembly; Virion.
FT   PROPEP          1..5
FT                   /evidence="ECO:0000269|PubMed:15342608"
FT                   /id="PRO_0000450224"
FT   CHAIN           6..208
FT                   /note="Baseplate hub assembly protein gp26"
FT                   /id="PRO_0000165014"
FT   CONFLICT        116..117
FT                   /note="FR -> SG (in Ref. 3)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   208 AA;  23882 MW;  C07000CB3C60883E CRC64;
     MYEYKFDVRV GSKIINCRAF TLKEYLELIT AKNNGSVEVI VKKLIKDCTN AKDLNRQESE
     LLLIHLWAHS LGEVNHENSW KCTCGTEIPT HINLLHTQID APEDLWYTLG DIKIKFRYPK
     IFDDKNIAHM IVSCIETIHA NGESIPVEDL NEKELEDLYS IITESDIVAI KDMLLKPTVY
     LAVPIKCPEC GKTHAHVIRG LKEFFELL