ID   GP2_EHV1B               Reviewed;         797 AA.
AC   P28968; Q66VC3; Q6DLE0;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-1992, sequence version 1.
DT   29-SEP-2021, entry version 83.
DE   RecName: Full=Glycoprotein gp2;
DE   AltName: Full=Glycoprotein X;
DE            Short=GpX;
DE   Flags: Precursor;
GN   Name=EUs4; OrderedLocusNames=71;
OS   Equine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX   NCBI_TaxID=31520;
OH   NCBI_TaxID=9796; Equus caballus (Horse).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=1318606; DOI=10.1016/0042-6822(92)90706-u;
RA   Telford E.A.R., Watson M.S., McBride K., Davison A.J.;
RT   "The DNA sequence of equine herpesvirus-1.";
RL   Virology 189:304-316(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=RacL11;
RX   PubMed=15795295; DOI=10.1128/jvi.79.8.5105-5115.2005;
RA   Smith P.M., Kahan S.M., Rorex C.B., von Einem J., Osterrieder N.,
RA   O'Callaghan D.J.;
RT   "Expression of the full-length form of gp2 of equine herpesvirus 1 (EHV-1)
RT   completely restores respiratory virulence to the attenuated EHV-1 strain
RT   KyA in CBA mice.";
RL   J. Virol. 79:5105-5115(2005).
CC   -!- FUNCTION: Virulence factor. {ECO:0000305|PubMed:15795295}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}; Single-pass
CC       membrane protein {ECO:0000305}.
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DR   EMBL; AY665713; AAT67328.1; -; Genomic_DNA.
DR   EMBL; AY702017; AAU09476.1; -; Genomic_DNA.
DR   PIR; H36802; VGBEX1.
DR   RefSeq; YP_053115.1; NC_001491.2.
DR   GeneID; 2948560; -.
DR   KEGG; vg:2948560; -.
DR   Proteomes; UP000001189; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016032; P:viral process; IEA:InterPro.
DR   InterPro; IPR010278; Varicellovirus_Gp2_glycop.
DR   Pfam; PF05955; Herpes_gp2; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix; Virion; Virulence.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..797
FT                   /note="Glycoprotein gp2"
FT                   /id="PRO_0000038296"
FT   TRANSMEM        766..790
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          24..188
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          212..549
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        212..491
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        590
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   VARIANT         221..222
FT                   /note="TA -> SS (in strain: RacL11)"
FT   VARIANT         226..238
FT                   /note="SSATTAATTTAAT -> AATTSSA (in strain: RacL11)"
FT   VARIANT         430
FT                   /note="T -> A (in strain: RacL11)"
FT   VARIANT         441
FT                   /note="E -> G (in strain: RacL11)"
SQ   SEQUENCE   797 AA;  80343 MW;  50C9ED9211F5E5B2 CRC64;
     MGFIYARKLL LCMAVSIYAI GSTTTTETTT SSSSTSGSGQ STSSGTTNSS SSPTTSPPTT
     SSSPPTSTHT SSPSSTSTQS SSTAATSSSA PSTASSTTSI PTSTSTETTT TTPTASTTTP
     TTTTAAPTTA ATTTAVTTAA STSAETTTAT ATATSTPTTT TPTSTTTTTA TTTVPTTAST
     TTDTTTAATT TAATTTAATT TAATTTAATT TAATTTAATT TAATTSSATT AATTTAATTT
     AATTTAATTT AATTTAATTT GSPTSGSTST TGASTSTPSA STATSATPTS TSTSAAATTS
     TPTPTSAATS AESTTEAPTS TPTTDTTTPS EATTATTSPE STTVSASTTS ATTTAFTTES
     HTSPDSSTGS TSTAEPSSTF TLTPSTATPS TDQFTGSSAS TESDSTDSST VPTTGTESIT
     ESSSTTEAST NLGSSTYEST EALETPDGNT TSGNTTPSPS PRTPSFADTQ QTPDNGVSTQ
     HTTINDHTTA NAQKHAGHHR GRAGGRRGSP QGGSHTTPHP DRLTPSPDDT YDDDTNHPNG
     RNNSIEIVPQ LPPDRPIIEL GVATLRKNFM EASCTVETNS GLAIFWKIGN ASVDAFNRGT
     THTRLMRNGV PVYALVSTLR VPWLNVIPLT KITCAACPTN LVAGDGVDLN SCTTKSTTIP
     CPGQQRTHIF FSAKGDRAVC ITSELVSQPT ITWSVGSDRL RNDGFSQTWY GIQPGVCGIL
     RSEVRIHRTT WRFGSTSKDY LCEVSASDSK TSDYKVLPNA HSTSNFALVA ATTLTVTILC
     LLCCLYCMLT RPRASVY