ID   GP2_EHV1K               Reviewed;         383 AA.
AC   P32515;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   02-JUN-2021, entry version 66.
DE   RecName: Full=Glycoprotein gp2;
DE   AltName: Full=Glycoprotein X;
DE            Short=GpX;
DE   Flags: Precursor;
GN   Name=US4; OrderedLocusNames=71;
OS   Equine herpesvirus 1 (strain Kentucky A) (EHV-1) (Equine abortion virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX   NCBI_TaxID=10329;
OH   NCBI_TaxID=9796; Equus caballus (Horse).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1316673; DOI=10.1016/0042-6822(92)90509-n;
RA   Colle C.F. III, Flowers C.C., O'Callaghan D.J.;
RT   "Open reading frames encoding a protein kinase, homolog of glycoprotein gX
RT   of pseudorabies virus, and a novel glycoprotein map within the unique short
RT   segment of equine herpesvirus type 1.";
RL   Virology 188:545-557(1992).
CC   -!- FUNCTION: The glycoprotein gp2 from the avirulent strain Kentucky A
CC       (KyA) is probably non functional since this strain harbors an in-frame
CC       deletion of 1,242 nucleotides in gene 71.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}; Single-pass
CC       membrane protein {ECO:0000305}.
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DR   EMBL; M87497; AAA46072.1; -; Genomic_DNA.
DR   PIR; C42538; VGBEKG.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016032; P:viral process; IEA:InterPro.
DR   InterPro; IPR010278; Varicellovirus_Gp2_glycop.
DR   Pfam; PF05955; Herpes_gp2; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Membrane; Signal; Transmembrane; Transmembrane helix; Virion.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..383
FT                   /note="Glycoprotein gp2"
FT                   /id="PRO_0000038295"
FT   TRANSMEM        354..371
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          24..136
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        24..79
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        48
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        128
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   383 AA;  41027 MW;  B390611414131C2B CRC64;
     MGFIYARKLL LCMAVSIYAI GSTTTTETTT SSSSTSGSGQ STSSGTTNSS SSPTTSPPTT
     SSSPPTSTHT SSPSTANAQK HAGHHRGRAG GRRGSPQGGS HTTPHPDRLT PSPDDTYDDD
     TNHPNGRNNS IEIVPQLPPD RPIIELGVAT LRKNFMEASC TVETNSDLAI FWKIGKPSVD
     AFNRGTTHTR LMRNGVPVYA LVSTLRVPWL NVIPLTKITC AACPTNLVAG DGVDLNSCTT
     KSTTIPCPGQ QRTHIFFSAK GDRAVCITSE LVSQPTITWS VGSDRLRNDG FSQTWYGIQP
     GVCGILRSEV RIHRTTWRFG STSKDYLCEV SASDSKTSDY KVLPNAHSTS NFALVAATTL
     TVTILCLLCC LYCMLTRPRA SVY