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GP350_EBVA8
ID   GP350_EBVA8             Reviewed;         886 AA.
AC   P68343; Q07284; Q1HVG6;
DT   09-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   09-NOV-2004, sequence version 1.
DT   23-FEB-2022, entry version 62.
DE   RecName: Full=Envelope glycoprotein GP350;
DE   AltName: Full=Membrane antigen;
DE            Short=MA;
GN   ORFNames=BLLF1;
OS   Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus.
OX   NCBI_TaxID=82830;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8393237; DOI=10.1006/viro.1993.1409;
RA   Lees J.F., Arrand J.E., Pepper S.V., Stewart J.P., Mackett M., Arrand J.R.;
RT   "The Epstein-Barr virus candidate vaccine antigen gp340/220 is highly
RT   conserved between virus types A and B.";
RL   Virology 195:578-586(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16490228; DOI=10.1016/j.virol.2006.01.015;
RA   Dolan A., Addison C., Gatherer D., Davison A.J., McGeoch D.J.;
RT   "The genome of Epstein-Barr virus type 2 strain AG876.";
RL   Virology 350:164-170(2006).
CC   -!- FUNCTION: Initiates virion attachment to host B-lymphocyte cell,
CC       leading to virus entry. Acts by binding to host CR2 at the surface of
CC       B-lymphocytes, facilitating the binding of viral glycoprotein gp42 to
CC       HLA class II molecules. Attachment triggers virion-host membrane fusion
CC       and invasion of the host cell (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with host CR2. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane; Single-pass membrane protein.
CC       Host membrane; Single-pass membrane protein. Note=Most abundant
CC       component of the viral envelope. {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=GP350;
CC         IsoId=P68343-1; Sequence=Displayed;
CC       Name=GP220;
CC         IsoId=P68343-2; Sequence=VSP_041035;
CC   -!- PTM: Extensively glycosylated. {ECO:0000250}.
CC   -!- BIOTECHNOLOGY: Primary surface antigen capable of inducing and reacting
CC       with virus-neutralizing antibodies. Almost all EBV candidate vaccines
CC       are based on gp350 proteins.
CC   -!- SIMILARITY: Belongs to the Epstein-Barr GP350 family. {ECO:0000305}.
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DR   EMBL; L07923; AAA02787.1; -; Genomic_DNA.
DR   EMBL; DQ279927; ABB89242.1; -; Genomic_DNA.
DR   RefSeq; YP_001129462.1; NC_009334.1.
DR   SMR; P68343; -.
DR   IntAct; P68343; 1.
DR   PRIDE; P68343; -.
DR   GeneID; 5176231; -.
DR   KEGG; vg:5176231; -.
DR   Proteomes; UP000007639; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR007796; Herpes_BLLF1.
DR   Pfam; PF05109; Herpes_BLLF1; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Glycoprotein; Host membrane; Host-virus interaction;
KW   Late protein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Virion.
FT   CHAIN           1..886
FT                   /note="Envelope glycoprotein GP350"
FT                   /id="PRO_0000116184"
FT   TOPO_DOM        1..839
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        840..860
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        861..886
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255"
FT   REGION          423..810
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        47
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        87
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        114
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        166
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        169
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        195
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        229
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        277
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        318
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        328
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        345
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        356
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        378
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        386
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        411
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        435
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        443
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        457
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        497
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        519
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        533
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        554
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        568
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        589
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        603
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        606
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        624
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        635
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        662
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        680
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        714
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        725
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        734
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        759
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        794
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        837
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         502..729
FT                   /note="Missing (in isoform GP220)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_041035"
SQ   SEQUENCE   886 AA;  92389 MW;  4394F6130DECCA8A CRC64;
     MEAALLVCQY TIQSLIQLTR DDPGFFNVEI LEFPFYPACN VCTADVNATI NFDVGGKKHK
     LNLDFGLLTP HTKAVYQPRG AFGGSENATN LFLLELLGAG ELALTMRSKK LPINITTGEE
     QQVSLESVDV YFQDVFGTMW CHHAEMQNPV YLIPETVPYI KWDNCNSTNI TAVVRAQGLD
     VTLPLSLPTS AQDSNFSVKT EMLGNEIDIE CIMEDGEISQ VLPGDNKFNI TCSGYESHVP
     SGGILTSTSP VATPIPGTGY AYSLRLTPRP VSRFLGNNSI LYVFYSGNGP KASGGDYCIQ
     SNIVFSDEIP ASQDMPTNTT DITYVGDNAT YSVPMVTSED ANSPNVTVTA FWAWPNNTET
     DFKCKWTLTS GTPSGCENIS GAFASNRTFD ITVSGLGTAP KTLIITRTAT NATTTTHKVI
     FSKAPESTTT SPTLNTTGFA APNTTTGLPS STHVPTNLTA PASTGPTVST ADVTSPTPAG
     TTSGASPVTP SPSPRDNGTE SKAPDMTSPT SAVTTPTPNA TSPTPAVTTP TPNATSPTLG
     KTSPTSAVTT PTPNATSPTP AVTTPTPNAT IPTLGKTSPT SAVTTPTPNA TSPTVGETSP
     QANTTNHTLG GTSSTPVVTS PPKNATSAVT TGQHNITSSS TSSMSLRPSS ISETLSPSTS
     DNSTSHMPLL TSAHPTGGEN ITQVTPASTS THHVSTSSPA PRPGTTSQAS GPGNSSTSTK
     PGEVNVTKGT PPKNATSPQA PSGQKTAVPT VTSTGGKANS TTGGKHTTGH GARTSTEPTT
     DYGGDSTTPR TRYNATTYLP PSTSSKLRPR WTFTSPPVTT AQATVPVPPT SQPRFSNLSM
     LVLQWASLAV LTLLLLLVMA DCAFRRNLST SHTYTTPPYD DAETYV
 
 
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