GP350_EBVG
ID GP350_EBVG Reviewed; 856 AA.
AC Q3KST4;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 23-FEB-2022, entry version 40.
DE RecName: Full=Envelope glycoprotein GP350;
DE AltName: Full=Membrane antigen;
DE Short=MA;
OS Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus.
OX NCBI_TaxID=10376;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16306603; DOI=10.1128/jvi.79.24.15323-15330.2005;
RA Zeng M.-S., Li D.-J., Liu Q.-L., Song L.-B., Li M.-Z., Zhang R.-H.,
RA Yu X.-J., Wang H.-M., Ernberg I., Zeng Y.-X.;
RT "Genomic sequence analysis of Epstein-Barr virus strain GD1 from a
RT nasopharyngeal carcinoma patient.";
RL J. Virol. 79:15323-15330(2005).
CC -!- FUNCTION: Initiates virion attachment to host B-lymphocyte cell,
CC leading to virus entry. Acts by binding to host CR2 at the surface of
CC B-lymphocytes, facilitating the binding of viral glycoprotein gp42 to
CC HLA class II molecules. Attachment triggers virion-host membrane fusion
CC and invasion of the host cell (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with host CR2. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Virion membrane; Single-pass membrane protein.
CC Host membrane; Single-pass membrane protein. Note=Most abundant
CC component of the viral envelope. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=GP350;
CC IsoId=Q3KST4-1; Sequence=Displayed;
CC Name=GP220;
CC IsoId=Q3KST4-2; Sequence=VSP_041036;
CC -!- PTM: Extensively glycosylated. {ECO:0000250}.
CC -!- BIOTECHNOLOGY: Primary surface antigen capable of inducing and reacting
CC with virus-neutralizing antibodies. Almost all EBV candidate vaccines
CC are based on gp350 proteins.
CC -!- SIMILARITY: Belongs to the Epstein-Barr GP350 family. {ECO:0000305}.
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DR EMBL; AY961628; AAY41116.1; -; Genomic_DNA.
DR SMR; Q3KST4; -.
DR Proteomes; UP000007641; Genome.
DR GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR007796; Herpes_BLLF1.
DR Pfam; PF05109; Herpes_BLLF1; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Glycoprotein; Host membrane; Host-virus interaction;
KW Late protein; Membrane; Transmembrane; Transmembrane helix; Virion.
FT CHAIN 1..856
FT /note="Envelope glycoprotein GP350"
FT /id="PRO_0000408265"
FT TOPO_DOM 1..809
FT /note="Virion surface"
FT /evidence="ECO:0000255"
FT TRANSMEM 810..830
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 831..856
FT /note="Intravirion"
FT /evidence="ECO:0000255"
FT REGION 421..779
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 47
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 87
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 114
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 166
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 169
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 195
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 229
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 277
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 318
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 328
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 345
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 356
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 378
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 386
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 411
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 435
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 443
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 457
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 497
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 519
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 533
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 554
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 568
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 582
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 585
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 603
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 614
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 650
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 684
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 695
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 704
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 729
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 764
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 807
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT VAR_SEQ 502..699
FT /note="Missing (in isoform GP220)"
FT /evidence="ECO:0000305"
FT /id="VSP_041036"
SQ SEQUENCE 856 AA; 89423 MW; 3EFB6F3192856D04 CRC64;
MEAALLVCQY TIQSLIHLTG EDPGFFNVEI PEFPFYPTCN VCTADVNVTI NFDVGGKKHQ
LDLDFGQLTP HTKAVYQPRG AFGGSENATN LFLLELLGAG ELALTMRSKK LPINVTTGEE
QQVSLESVDV YFQDVFGTMW CHHAEMQNPV YLIPETVPYI KWDNCNSTNI TAVVRAQGLD
VTLPLSLPTS AQDSNFSVKT QMLGNEIDIE CIMEDGEISQ VLPGDNKFNI TCSGYESHVP
SGGILTSTSP VVTPIPGTGY AYSLRLTPRP VSRFLGNNSI LYVFYSGNGP KASGGDYCIQ
SNIVFSDEIP ASQDMPTNTT DITYVGDNAT YSVPMVTSED ANSPNVTVTA FWAWPNNTET
DFKCKWTLTS GTPSGCENIS GAFASNRTFD ITVSGLGTAP KTLIITRTAT NATTTTHKVI
FSKAPESTTT SPTSNTTGFA APNTTTGLPS STHVPTNLTA PASTGPTVST ADVTSPTPAG
TTSGASPVTP SPSPRDNGTE SKAPDMTSPT PAVTTPTPNA TSPTSAVTTP TPNATSPTLG
KTSPTSAVTT PTPNATSPTS AVTTPTPNAT GPTVGETSPQ ANTTNHTLGG TSSTPVVTSQ
PKNATSAVTT GQHNITSSST SSMSLRPSSI SETTSHMPLL TSAHPTGGEN ITQVTPASTS
THHVSTSSPA PRPGTTSQAS GPGNSSTSTK PGEVNVTKGT PPKNATSPQA PSGQKTAVPT
VTSTGGKANS TTGGKHTTGH GARTSTEPTT DYGGDSTTPR TRYNATTYLP PSTSSELRPR
WTFTSPPVTT AQATVPVPPT SQPRFSNLSM LVLQWASLAV LTLLLLLVMA DCAFRRNLST
SHTYTTPPYD DAETYV
