GP41_NPVAC
ID GP41_NPVAC Reviewed; 409 AA.
AC P32651;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 2.
DT 25-MAY-2022, entry version 76.
DE RecName: Full=Structural glycoprotein gp41;
GN Name=GP41;
OS Autographa californica nuclear polyhedrosis virus (AcMNPV).
OC Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX NCBI_TaxID=46015;
OH NCBI_TaxID=7088; Lepidoptera (butterflies and moths).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=HR3;
RX PubMed=1629955; DOI=10.1128/jvi.66.8.4763-4768.1992;
RA Whitford M., Faulkner P.;
RT "Nucleotide sequence and transcriptional analysis of a gene encoding gp41,
RT a structural glycoprotein of the baculovirus Autographa californica nuclear
RT polyhedrosis virus.";
RL J. Virol. 66:4763-4768(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=E2;
RX PubMed=8126447; DOI=10.1099/0022-1317-75-3-487;
RA Kool M., Broer R., Zuidema D., Goldbach R.W., Vlak J.M.;
RT "Nucleotide sequence and genetic organization of a 7.3 kb region (map unit
RT 47 to 52.5) of Autographa californica nuclear polyhedrosis virus fragment
RT EcoRI-C.";
RL J. Gen. Virol. 75:487-494(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C6;
RX PubMed=8030224; DOI=10.1006/viro.1994.1380;
RA Ayres M.D., Howard S.C., Kuzio J., Lopez-Ferber M., Possee R.D.;
RT "The complete DNA sequence of Autographa californica nuclear polyhedrosis
RT virus.";
RL Virology 202:586-605(1994).
RN [4]
RP GLYCOSYLATION.
RX PubMed=1583718; DOI=10.1128/jvi.66.6.3324-3329.1992;
RA Whitford M., Faulkner P.;
RT "A structural polypeptide of the baculovirus Autographa californica nuclear
RT polyhedrosis virus contains O-linked N-acetylglucosamine.";
RL J. Virol. 66:3324-3329(1992).
RN [5]
RP SUBCELLULAR LOCATION, AND FUNCTION.
RX PubMed=9217053; DOI=10.1006/viro.1997.8612;
RA Olszewski J., Miller L.K.;
RT "A role for baculovirus GP41 in budded virus production.";
RL Virology 233:292-301(1997).
RN [6]
RP FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, AND REGION.
RX PubMed=29643237; DOI=10.1128/jvi.02083-17;
RA Li Y., Shen S., Hu L., Deng F., Vlak J.M., Hu Z., Wang H., Wang M.;
RT "The functional oligomeric state of tegument protein GP41 is essential for
RT baculovirus BV and ODV assembly.";
RL J. Virol. 0:0-0(2018).
CC -!- FUNCTION: Major tegument protein that participates in the egress of
CC nucleocapsids from the host nucleus. May be involved in host nucleus-
CC cytoplasm transportation of nucleocapsids to form budded virion (BVs).
CC {ECO:0000269|PubMed:29643237, ECO:0000269|PubMed:9217053}.
CC -!- SUBUNIT: Homooligomer. Homotrimer. Forms oligomers in infected cells,
CC while selectively assembles as trimers into progeny virions.
CC {ECO:0000269|PubMed:29643237}.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000269|PubMed:29643237,
CC ECO:0000269|PubMed:9217053}. Host nucleus {ECO:0000305|PubMed:9217053}.
CC Note=Localizes in both the budded virions (BVs) and occlusion-derived
CC virions (ODVs) but amount in BVs is much lower than that in ODVs.
CC {ECO:0000269|PubMed:29643237}.
CC -!- DEVELOPMENTAL STAGE: Associated with the polyhedron-derived virus
CC (occluded virus).
CC -!- PTM: O-glycosylated; by N-acetylglucosamine at one or more locations.
CC {ECO:0000269|PubMed:1583718}.
CC -!- SIMILARITY: Belongs to the baculoviridae gp41 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; M86592; AAA46695.1; -; Genomic_DNA.
DR EMBL; X71415; CAA50543.1; -; Genomic_DNA.
DR EMBL; L22858; AAA66710.1; -; Genomic_DNA.
DR PIR; A42738; WMNV41.
DR PIR; A72860; A72860.
DR PIR; S36696; S36696.
DR RefSeq; NP_054110.1; NC_001623.1.
DR PRIDE; P32651; -.
DR GeneID; 1403913; -.
DR KEGG; vg:1403913; -.
DR Proteomes; UP000008292; Genome.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0044423; C:virion component; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR InterPro; IPR006790; Baculovirus_Gp41.
DR Pfam; PF04700; Baculo_gp41; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Host nucleus; Late protein; Reference proteome; Virion.
FT CHAIN 1..409
FT /note="Structural glycoprotein gp41"
FT /id="PRO_0000132903"
FT REGION 201..214
FT /note="Leucine zipper 1 (LZ1)"
FT /evidence="ECO:0000269|PubMed:29643237"
FT REGION 367..380
FT /note="Leucine zipper 2 (LZ2)"
FT /evidence="ECO:0000269|PubMed:29643237"
FT CARBOHYD 128
FT /note="O-linked (GlcNAc) threonine; by host"
FT /evidence="ECO:0000255"
FT CONFLICT 193
FT /note="A -> V (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 345..409
FT /note="ANAVNSPAAHLTKSACQESLTELAFQNETLRRFIFQQINYNKDANAIIAAAA
FT PNATRPNTKGRTA -> PTRSIRRPLI (in Ref. 1; AAA46695)"
FT /evidence="ECO:0000305"
FT CONFLICT 397..409
FT /note="PNATRPNTKGRTA -> R (in Ref. 2)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 409 AA; 45382 MW; 1C1ACADC08FABB1B CRC64;
MTDERGNFYY NTPPPLRYPS NPATAIFTSA QTYNAPGYVP PATVPTTVAT RDNRMDYTSR
SNSTNSVAIA PYNKSKEPTL DAGESIWYNK CVDFVQKIIR YYRCNDMSEL SPLMILFINT
IRDMCIDTNP ISVNVVKRFE SEETMIRHLI RLQKELGQSN AAESLSSDSN IFQPSFVLNS
LPAYAQKFYN GGADMLGKDA LAEAAKQLSL AVQYMVAEAV TCNIPIPLPF NQQLANNYMT
LLLKHATLPP NIQSAVESRR FPHINMINDL INAVIDDLFA GGGDYYHYVL NEKNRARVMS
LKENVAFLAP LSASANIFNY MAELATRAGK QPSMFQNATF LTSAANAVNS PAAHLTKSAC
QESLTELAFQ NETLRRFIFQ QINYNKDANA IIAAAAPNAT RPNTKGRTA
