ID   GP46_LEIAM              Reviewed;         476 AA.
AC   P21978;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1991, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Surface membrane glycoprotein GP46/M-2;
DE   Flags: Precursor;
OS   Leishmania amazonensis.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5659;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 33-61.
RC   STRAIN=MHOM/BR/77/LTB0016/C1S1;
RX   PubMed=2236047; DOI=10.1073/pnas.87.21.8393;
RA   Lohman K.L., Langer P.J., McMahon-Pratt D.;
RT   "Molecular cloning and characterization of the immunologically protective
RT   surface glycoprotein GP46/M-2 of Leishmania amazonensis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 87:8393-8397(1990).
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
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DR   EMBL; M38368; AAA29234.1; -; Genomic_DNA.
DR   PIR; A36478; A36478.
DR   AlphaFoldDB; P21978; -.
DR   SMR; P21978; -.
DR   VEuPathDB; TriTrypDB:LAMA_000409600; -.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005929; C:cilium; IEA:UniProt.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR006311; TAT_signal.
PE   1: Evidence at protein level;
KW   Cell membrane; Direct protein sequencing; Glycoprotein; GPI-anchor;
KW   Lipoprotein; Membrane; Repeat; Signal.
FT   SIGNAL          1..32
FT                   /evidence="ECO:0000269|PubMed:2236047"
FT   CHAIN           33..452
FT                   /note="Surface membrane glycoprotein GP46/M-2"
FT                   /id="PRO_0000021354"
FT   PROPEP          453..476
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000021355"
FT   REPEAT          107..130
FT                   /note="1"
FT   REPEAT          131..154
FT                   /note="2"
FT   REPEAT          155..178
FT                   /note="3"
FT   REPEAT          179..202
FT                   /note="4"
FT   REGION          107..202
FT                   /note="4 X 24 AA tandem repeats"
FT   REGION          231..255
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          348..370
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           452
FT                   /note="GPI-anchor amidated cysteine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        40
FT                   /note="G -> E (in Ref. 1; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        44
FT                   /note="K -> T (in Ref. 1; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   476 AA;  50137 MW;  722F5DDC48C30BBB CRC64;
     MAQCVRRLVL AAPLAAVVAL LLCTSSAPVA RAAGTSDFTG AQQKNTLTVL QAFARAIPAL
     GDTWTGSDFC SWEHIICYSS GVGVWMHNVD YTGTLPEMPA SVDYKDVMIL ALDFGAMGQG
     LSGTLPPSWS SMKHLIVLDL EGTKVSGTLP PEWSEMTSAE ALQLENCGLS GSLPTSWSSM
     PKLRIVSLSG NHFCGCVPDS WREKDRLDVT IEEWHMGEDC KLANACRPTA APGTTTTNPP
     TTTGTPAASS TPSPGSGCEV DGCEVCEGDS AARCARCREG YSLTDEKTCL GEPRWRRGGG
     VERTAGCRCC VGGCAVERGA GGVRVRRAPL LCGAPGACPR PRHGVVAALS PPPADGETDS
     HTRTRTRRRA SRVLSAVVAP ARMHGHAEAC MRVRVPALVC LSVWPAVGTR RRSNVRAAAV
     CRLGQRRCGA RPSPCASVCV SWPRERRTEC ACPALFDGAR LRCCALVVCA GAAPAG