ID   GP56_BPSP1              Reviewed;          79 AA.
AC   O48410; B6V2W3;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 37.
DE   RecName: Full=Inhibitor of host cell division protein {ECO:0000305};
DE   AltName: Full=Gene 56 protein {ECO:0000312|EMBL:ACI90931.1};
DE            Short=Gp56 {ECO:0000312|EMBL:ACI90931.1};
GN   Name=56 {ECO:0000312|EMBL:ACI90931.1};
GN   ORFNames=SPO1_26 {ECO:0000312|EMBL:ACI90931.1};
OS   Bacillus phage SP01 (Bacteriophage SP01).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Herelleviridae; Spounavirinae; Okubovirus.
OX   NCBI_TaxID=10685 {ECO:0000312|Proteomes:UP000001590};
OH   NCBI_TaxID=1423; Bacillus subtilis.
RN   [1] {ECO:0000312|EMBL:AAC29025.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9657951; DOI=10.1006/viro.1998.9197;
RA   Stewart C.R., Gaslightwala I., Hinata K., Krolikowski K.A., Needleman D.S.,
RA   Peng A.S.-Y., Peterman M.A., Tobias A., Wei P.;
RT   "Genes and regulatory sites of the 'host-takeover module' in the terminal
RT   redundancy of Bacillus subtilis bacteriophage SPO1.";
RL   Virology 246:329-340(1998).
RN   [2] {ECO:0000312|EMBL:ACI90931.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=19285085; DOI=10.1016/j.jmb.2009.03.009;
RA   Stewart C.R., Casjens S.R., Cresawn S.G., Houtz J.M., Smith A.L.,
RA   Ford M.E., Peebles C.L., Hatfull G.F., Hendrix R.W., Huang W.M.,
RA   Pedulla M.L.;
RT   "The genome of Bacillus subtilis bacteriophage SPO1.";
RL   J. Mol. Biol. 388:48-70(2009).
RN   [3]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=24210121; DOI=10.1016/j.virol.2013.09.005;
RA   Stewart C.R., Deery W.J., Egan E.S., Myles B., Petti A.A.;
RT   "The product of SPO1 gene 56 inhibits host cell division during infection
RT   of Bacillus subtilis by bacteriophage SPO1.";
RL   Virology 447:249-253(2013).
CC   -!- FUNCTION: Inhibits host cell division leading to filamentation
CC       (PubMed:24210121). Does not prevent host cell growth, DNA synthesis or
CC       chromosome segregation (PubMed:24210121). Does not seem to be essential
CC       for productive bacterial host infection (PubMed:24210121).
CC       {ECO:0000269|PubMed:24210121}.
CC   -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000255}.
CC   -!- DISRUPTION PHENOTYPE: Disrupts inhibition of host cell division
CC       (PubMed:24210121). Has no effect on host DNA synthesis, burst size or
CC       latent period during infection (PubMed:24210121).
CC       {ECO:0000269|PubMed:24210121}.
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DR   EMBL; AF031901; AAC29025.1; -; Genomic_DNA.
DR   EMBL; FJ230960; ACI90931.1; -; Genomic_DNA.
DR   RefSeq; YP_002300302.1; NC_011421.1.
DR   SMR; O48410; -.
DR   PRIDE; O48410; -.
DR   GeneID; 7009015; -.
DR   KEGG; vg:7009015; -.
DR   Proteomes; UP000001590; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Coiled coil; Host membrane; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..79
FT                   /note="Inhibitor of host cell division protein"
FT                   /id="PRO_0000106162"
FT   TRANSMEM        37..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   COILED          15..35
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   79 AA;  9305 MW;  9783ABB51E0A609A CRC64;
     MFKYTDRSVR QYIERQQRSA MLEQEQAEKD KKERRKAGLL FFGTIVVLVA VVAVYIVPQS
     LDAMWHENYE KPAQEAARN