3S1B1_NAJKA
ID 3S1B1_NAJKA Reviewed; 62 AA.
AC P14613;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1990, sequence version 1.
DT 25-MAY-2022, entry version 93.
DE RecName: Full=Short neurotoxin 1;
DE AltName: Full=Toxin C-6;
OS Naja kaouthia (Monocled cobra) (Naja siamensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Naja.
OX NCBI_TaxID=8649;
RN [1]
RP PROTEIN SEQUENCE, AND SUBCELLULAR LOCATION.
RC TISSUE=Venom;
RX PubMed=2807733; DOI=10.1111/j.1399-3011.1989.tb01504.x;
RA Chiou S.-H., Lin W.-W., Chang W.-P.;
RT "Sequence characterization of venom toxins from Thailand cobra.";
RL Int. J. Pept. Protein Res. 34:148-152(1989).
CC -!- FUNCTION: Binds to muscle nicotinic acetylcholine receptor (nAChR) and
CC inhibit acetylcholine from binding to the receptor, thereby impairing
CC neuromuscular transmission. {ECO:0000250|UniProtKB:P60775}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:2807733}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the snake three-finger toxin family. Short-chain
CC subfamily. Type I alpha-neurotoxin sub-subfamily. {ECO:0000305}.
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DR PIR; JK0221; JK0221.
DR AlphaFoldDB; P14613; -.
DR BMRB; P14613; -.
DR SMR; P14613; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR CDD; cd00206; snake_toxin; 1.
DR Gene3D; 2.10.60.10; -; 1.
DR InterPro; IPR003571; Snake_3FTx.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR InterPro; IPR018354; Snake_toxin_con_site.
DR SUPFAM; SSF57302; SSF57302; 1.
DR PROSITE; PS00272; SNAKE_TOXIN; 1.
PE 1: Evidence at protein level;
KW Acetylcholine receptor inhibiting toxin; Direct protein sequencing;
KW Disulfide bond; Ion channel impairing toxin; Neurotoxin;
KW Postsynaptic neurotoxin; Secreted; Toxin.
FT CHAIN 1..62
FT /note="Short neurotoxin 1"
FT /evidence="ECO:0000269|PubMed:2807733"
FT /id="PRO_0000093613"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 3..24
FT /evidence="ECO:0000250|UniProtKB:P0C1Z0"
FT DISULFID 17..41
FT /evidence="ECO:0000250|UniProtKB:P0C1Z0"
FT DISULFID 43..54
FT /evidence="ECO:0000250|UniProtKB:P0C1Z0"
FT DISULFID 55..60
FT /evidence="ECO:0000250|UniProtKB:P0C1Z0"
SQ SEQUENCE 62 AA; 6983 MW; 3D975DAD4B13E203 CRC64;
LECHNQQSIQ TPTTTGCSGG ETNCYKKRWR DHRGYRTERG CGCPSVKNGI EINCCTTDRC
NN