ID   GP7D_CHLMU              Reviewed;         305 AA.
AC   Q46435;
DT   11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Virulence plasmid integrase pGP7-D;
GN   OrderedLocusNames=TC_A01;
OS   Chlamydia muridarum (strain MoPn / Nigg).
OG   Plasmid pMoPn.
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=243161;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=MoPn / Nigg;
RX   PubMed=9202459; DOI=10.1099/00221287-143-6-1847;
RA   Thomas N.S., Lusher M., Storey C.C., Clarke I.N.;
RT   "Plasmid diversity in Chlamydia.";
RL   Microbiology 143:1847-1854(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MoPn / Nigg;
RX   PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA   Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O.,
RA   Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S.,
RA   Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J.,
RA   Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G.,
RA   Salzberg S.L., Eisen J.A., Fraser C.M.;
RT   "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae
RT   AR39.";
RL   Nucleic Acids Res. 28:1397-1406(2000).
CC   -!- SIMILARITY: Belongs to the 'phage' integrase family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X78726; CAA55372.1; -; Genomic_DNA.
DR   EMBL; AE002162; AAF39715.1; -; Genomic_DNA.
DR   PIR; S44159; S44159.
DR   RefSeq; WP_010231978.1; NZ_ACOV01000005.1.
DR   AlphaFoldDB; Q46435; -.
DR   SMR; Q46435; -.
DR   PRIDE; Q46435; -.
DR   EnsemblBacteria; AAF39715; AAF39715; TC_A01.
DR   GeneID; 1245522; -.
DR   KEGG; cmu:TC_A01; -.
DR   PATRIC; fig|243161.6.peg.1; -.
DR   eggNOG; COG0582; Bacteria.
DR   HOGENOM; CLU_078727_0_0_0; -.
DR   OMA; SGLSHYH; -.
DR   OrthoDB; 745068at2; -.
DR   PHI-base; PHI:4929; -.
DR   Proteomes; UP000000800; Plasmid pMoPn.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.443.10; -; 1.
DR   InterPro; IPR044068; CB.
DR   InterPro; IPR011010; DNA_brk_join_enz.
DR   InterPro; IPR013762; Integrase-like_cat_sf.
DR   InterPro; IPR002104; Integrase_catalytic.
DR   Pfam; PF00589; Phage_integrase; 1.
DR   SUPFAM; SSF56349; SSF56349; 1.
DR   PROSITE; PS51900; CB; 1.
DR   PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE   3: Inferred from homology;
KW   DNA integration; DNA recombination; DNA-binding; Plasmid;
KW   Viral genome integration; Virus entry into host cell.
FT   CHAIN           1..305
FT                   /note="Virulence plasmid integrase pGP7-D"
FT                   /id="PRO_0000197561"
FT   DOMAIN          13..99
FT                   /note="Core-binding (CB)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01248"
FT   DOMAIN          127..303
FT                   /note="Tyr recombinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        188
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        257
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        289
FT                   /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
SQ   SEQUENCE   305 AA;  34592 MW;  91381FD229F25D5F CRC64;
     MNSKFYHRSR LFLTFGEASE IWLSTLSPLT RKNYASGIKF LVSLKVLDLT KTLDNAISFD
     HSESLFKIKS LTIFNGKPVS EASKQARAAC YISFTKFLYR LTKGYINPAI PLKDFGNTTF
     FKIRDRVKTV SISKKEWTVF FEALRLVSYR DYLIGKLIVQ GIRKLDEILS LCMEDLFFAS
     NQISFRIKKR QNKEINIPIT FPFSLMKELK DYVGGRNGRV FISEDGSPIA TSQVVHNFKI
     AALRSAMTTK ITPRVLRASA LIHLKQMGLR DEEIMRVSCL SSKQSLCSYV CSGGNSSVAN
     IPTIL