GP7D_CHLT2
ID GP7D_CHLT2 Reviewed; 305 AA.
AC B0BCM5; P10561; Q46427;
DT 02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 02-MAR-2010, sequence version 2.
DT 25-MAY-2022, entry version 48.
DE RecName: Full=Virulence plasmid integrase pGP7-D;
DE AltName: Full=Protein P-11;
GN OrderedLocusNames=pL2-01;
OS Chlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B).
OG Plasmid pL2, and Plasmid pLGV440.
OC Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC Chlamydia/Chlamydophila group; Chlamydia.
OX NCBI_TaxID=471472;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC PLASMID=pLGV440;
RX PubMed=2845228; DOI=10.1111/j.1365-2958.1988.tb00060.x;
RA Comanducci M., Ricci S., Ratti G.;
RT "The structure of a plasmid of Chlamydia trachomatis believed to be
RT required for growth within mammalian cells.";
RL Mol. Microbiol. 2:531-538(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=434/Bu / ATCC VR-902B; PLASMID=pL2;
RX PubMed=18032721; DOI=10.1101/gr.7020108;
RA Thomson N.R., Holden M.T.G., Carder C., Lennard N., Lockey S.J., Marsh P.,
RA Skipp P., O'Connor C.D., Goodhead I., Norbertzcak H., Harris B., Ormond D.,
RA Rance R., Quail M.A., Parkhill J., Stephens R.S., Clarke I.N.;
RT "Chlamydia trachomatis: genome sequence analysis of lymphogranuloma
RT venereum isolates.";
RL Genome Res. 18:161-171(2008).
CC -!- MISCELLANEOUS: pGP7-D is required for growth within mammalian cells.
CC -!- SIMILARITY: Belongs to the 'phage' integrase family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA30427.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=CAP09063.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; X07547; CAA30427.1; ALT_FRAME; Genomic_DNA.
DR EMBL; AM886278; CAP09063.1; ALT_FRAME; Genomic_DNA.
DR PIR; S01925; S01925.
DR AlphaFoldDB; B0BCM5; -.
DR SMR; B0BCM5; -.
DR Proteomes; UP000000795; Plasmid pL2.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
DR Gene3D; 1.10.443.10; -; 1.
DR InterPro; IPR044068; CB.
DR InterPro; IPR011010; DNA_brk_join_enz.
DR InterPro; IPR013762; Integrase-like_cat_sf.
DR InterPro; IPR002104; Integrase_catalytic.
DR Pfam; PF00589; Phage_integrase; 1.
DR SUPFAM; SSF56349; SSF56349; 1.
DR PROSITE; PS51900; CB; 1.
DR PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE 3: Inferred from homology;
KW DNA integration; DNA recombination; DNA-binding; Plasmid;
KW Viral genome integration; Virus entry into host cell.
FT CHAIN 1..305
FT /note="Virulence plasmid integrase pGP7-D"
FT /id="PRO_0000391802"
FT DOMAIN 13..99
FT /note="Core-binding (CB)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01248"
FT DOMAIN 127..305
FT /note="Tyr recombinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT ACT_SITE 188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT ACT_SITE 257
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT ACT_SITE 289
FT /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
SQ SEQUENCE 305 AA; 34806 MW; 048C77FB84A42C19 CRC64;
MGSMAFHKSR LFLTFGDASE IWLSTLSHLT RKNYASGINF LVSLEILDLS ETLIKAISLD
HSESLFKIKS LDVFNGKVVS EASKQARAAC YISFTKFLYR LTKGYIKPAI PLKDFGNTTF
FKIRDKIKTE SISKQEWTVF FEALRIVNYR DYLIGKLIVQ GIRKLDEILS LRTDDLFFAS
NQISFRIKKR QNKETKILIT FPISLMEELQ KYTCGRNGRV FVSKIGIPVT TSQVAHNFRL
AEFYSAMKIK ITPRVLRASA LIHLKQIGLK DEEIMRISCL SSRQSVCSYC SGEEVSPLVQ
TPPIL
