ID   GP7D_CHLTH              Reviewed;         305 AA.
AC   P0CE19; P10561; Q46427;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   02-MAR-2010, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=Virulence plasmid integrase pGP7-D;
DE   AltName: Full=Protein P-11;
OS   Chlamydia trachomatis.
OG   Plasmid pLGV440, Plasmid pCHL1, and Plasmid pCTT1.
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=813;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=L1/440/LN; PLASMID=pLGV440;
RX   PubMed=2836808; DOI=10.1093/nar/16.9.4053;
RA   Hatt C., Ward M.E., Clarke I.N.;
RT   "Analysis of the entire nucleotide sequence of the cryptic plasmid of
RT   Chlamydia trachomatis serovar L1. Evidence for involvement in DNA
RT   replication.";
RL   Nucleic Acids Res. 16:4053-4067(1988).
RN   [2]
RP   SEQUENCE REVISION.
RA   Hatt C.;
RL   Submitted (APR-1994) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=D/GO/86; PLASMID=pCHL1;
RX   PubMed=2194229; DOI=10.1016/0147-619x(90)90034-a;
RA   Comanducci M., Ricci S., Cevenini R., Ratti G.;
RT   "Diversity of the Chlamydia trachomatis common plasmid in biovars with
RT   different pathogenicity.";
RL   Plasmid 23:149-154(1990).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Serotype B; PLASMID=pCTT1;
RX   PubMed=3444859; DOI=10.1016/0147-619x(87)90063-1;
RA   Sriprakash K.S., Macavoy E.S.;
RT   "Characterization and sequence of a plasmid from the trachoma biovar of
RT   Chlamydia trachomatis.";
RL   Plasmid 18:205-214(1987).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   PLASMID=pCHL1;
RX   PubMed=7683369; DOI=10.1007/bf00279434;
RA   Ricci S., Cevenini R., Cosco E., Comanducci M., Ratti G., Scarlato V.;
RT   "Transcriptional analysis of the Chlamydia trachomatis plasmid pCT
RT   identifies temporally regulated transcripts, anti-sense RNA and sigma 70-
RT   selected promoters.";
RL   Mol. Gen. Genet. 237:318-326(1993).
CC   -!- MISCELLANEOUS: pGP7-D is required for growth within mammalian cells.
CC   -!- SIMILARITY: Belongs to the 'phage' integrase family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB02584.1; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=AAB02592.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X06707; CAA29890.1; -; Genomic_DNA.
DR   EMBL; J03321; AAA91567.1; -; Genomic_DNA.
DR   EMBL; M19487; AAB02592.1; ALT_INIT; Genomic_DNA.
DR   EMBL; M19487; AAB02584.1; ALT_FRAME; Genomic_DNA.
DR   PIR; S01875; S01875.
DR   RefSeq; NP_040380.1; NC_001372.1.
DR   RefSeq; WP_010889882.1; NZ_CVNT01000004.1.
DR   RefSeq; WP_012209813.1; NZ_CVNC01000027.1.
DR   RefSeq; YP_001569034.1; NC_010029.2.
DR   RefSeq; YP_001654086.1; NC_010286.1.
DR   RefSeq; YP_002842022.1; NC_012625.1.
DR   RefSeq; YP_002842030.1; NC_012626.1.
DR   RefSeq; YP_002842067.1; NC_012631.1.
DR   AlphaFoldDB; P0CE19; -.
DR   SMR; P0CE19; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.443.10; -; 1.
DR   InterPro; IPR044068; CB.
DR   InterPro; IPR011010; DNA_brk_join_enz.
DR   InterPro; IPR013762; Integrase-like_cat_sf.
DR   InterPro; IPR002104; Integrase_catalytic.
DR   Pfam; PF00589; Phage_integrase; 1.
DR   SUPFAM; SSF56349; SSF56349; 1.
DR   PROSITE; PS51900; CB; 1.
DR   PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE   3: Inferred from homology;
KW   DNA integration; DNA recombination; DNA-binding; Plasmid;
KW   Viral genome integration; Virus entry into host cell.
FT   CHAIN           1..305
FT                   /note="Virulence plasmid integrase pGP7-D"
FT                   /id="PRO_0000197563"
FT   DOMAIN          13..99
FT                   /note="Core-binding (CB)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01248"
FT   DOMAIN          127..305
FT                   /note="Tyr recombinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        188
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        257
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        289
FT                   /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   VARIANT         28
FT                   /note="H -> Y (in plasmid pCHL1)"
FT   VARIANT         244
FT                   /note="Y -> H (in plasmid pCHL1 and plasmid pCTT1)"
FT   VARIANT         296
FT                   /note="S -> I (in plasmid pCHL1)"
FT   VARIANT         303
FT                   /note="P -> T (in plasmid pCHL1 and plasmid pCTT1)"
SQ   SEQUENCE   305 AA;  34806 MW;  048C77FB84A42C19 CRC64;
     MGSMAFHKSR LFLTFGDASE IWLSTLSHLT RKNYASGINF LVSLEILDLS ETLIKAISLD
     HSESLFKIKS LDVFNGKVVS EASKQARAAC YISFTKFLYR LTKGYIKPAI PLKDFGNTTF
     FKIRDKIKTE SISKQEWTVF FEALRIVNYR DYLIGKLIVQ GIRKLDEILS LRTDDLFFAS
     NQISFRIKKR QNKETKILIT FPISLMEELQ KYTCGRNGRV FVSKIGIPVT TSQVAHNFRL
     AEFYSAMKIK ITPRVLRASA LIHLKQIGLK DEEIMRISCL SSRQSVCSYC SGEEVSPLVQ
     TPPIL