ID   GP8D_CHLMU              Reviewed;         330 AA.
AC   Q46436; Q9PLU7;
DT   11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Virulence plasmid integrase pGP8-D;
GN   OrderedLocusNames=TC_A02;
OS   Chlamydia muridarum (strain MoPn / Nigg).
OG   Plasmid pMoPn.
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=243161;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=MoPn / Nigg;
RX   PubMed=9202459; DOI=10.1099/00221287-143-6-1847;
RA   Thomas N.S., Lusher M., Storey C.C., Clarke I.N.;
RT   "Plasmid diversity in Chlamydia.";
RL   Microbiology 143:1847-1854(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MoPn / Nigg;
RX   PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA   Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O.,
RA   Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S.,
RA   Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J.,
RA   Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G.,
RA   Salzberg S.L., Eisen J.A., Fraser C.M.;
RT   "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae
RT   AR39.";
RL   Nucleic Acids Res. 28:1397-1406(2000).
CC   -!- SIMILARITY: Belongs to the 'phage' integrase family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF39714.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X78726; CAA55373.1; -; Genomic_DNA.
DR   EMBL; AE002162; AAF39714.1; ALT_INIT; Genomic_DNA.
DR   PIR; S44160; S44160.
DR   RefSeq; WP_010231981.1; NZ_ACOV01000005.1.
DR   AlphaFoldDB; Q46436; -.
DR   SMR; Q46436; -.
DR   STRING; 243161.TC_A02; -.
DR   EnsemblBacteria; AAF39714; AAF39714; TC_A02.
DR   GeneID; 1245521; -.
DR   KEGG; cmu:TC_A02; -.
DR   PATRIC; fig|243161.6.peg.2; -.
DR   eggNOG; COG0582; Bacteria.
DR   HOGENOM; CLU_078727_0_0_0; -.
DR   OrthoDB; 745068at2; -.
DR   Proteomes; UP000000800; Plasmid pMoPn.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.443.10; -; 1.
DR   InterPro; IPR044068; CB.
DR   InterPro; IPR011010; DNA_brk_join_enz.
DR   InterPro; IPR013762; Integrase-like_cat_sf.
DR   InterPro; IPR002104; Integrase_catalytic.
DR   Pfam; PF00589; Phage_integrase; 1.
DR   SUPFAM; SSF56349; SSF56349; 1.
DR   PROSITE; PS51900; CB; 1.
DR   PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE   3: Inferred from homology;
KW   DNA integration; DNA recombination; DNA-binding; Plasmid;
KW   Viral genome integration; Virus entry into host cell.
FT   CHAIN           1..330
FT                   /note="Virulence plasmid integrase pGP8-D"
FT                   /id="PRO_0000197564"
FT   DOMAIN          39..124
FT                   /note="Core-binding (CB)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01248"
FT   DOMAIN          152..327
FT                   /note="Tyr recombinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        189
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        214
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        279
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        282
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        305
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        314
FT                   /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
SQ   SEQUENCE   330 AA;  37765 MW;  6CAFABFAF7FCAC63 CRC64;
     MGKGILSLQQ EMPLEYIGKS YQEVLKIRQE SYWKRMRSFS LFEVIMHWTA SLNQHTCRSY
     RGSFLALEKI GLLSLDMNLQ EFSLLNHNLI LDAIKKIPSS KASWTEGTKQ VRAASYISLT
     RFLNRMTQGI VSIAQPSKQE NSRTFFKTRE IVKTNAMNRL QTASFLKELK KINPRDWLIA
     QTMLQGGKRS SEVLSLEIDQ ICFQQATISF SQLKNRQTEK RIIITYPQKF MHALREYIGP
     RRGLVFVTSS GKMVGLRQIA RTFSQAGLQA SIPFKITPHV LRATAVTEYK RLGCSDSDIM
     KVTGHTTAKM VFAYDKSSRE DNASKKMALI