ID   GP8D_CHLPS              Reviewed;         335 AA.
AC   Q46258;
DT   11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Virulence plasmid integrase pGP8-D;
OS   Chlamydia psittaci (Chlamydophila psittaci).
OG   Plasmid pCpA1.
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=83554;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=N352;
RX   PubMed=9202459; DOI=10.1099/00221287-143-6-1847;
RA   Thomas N.S., Lusher M., Storey C.C., Clarke I.N.;
RT   "Plasmid diversity in Chlamydia.";
RL   Microbiology 143:1847-1854(1997).
CC   -!- SIMILARITY: Belongs to the 'phage' integrase family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X62475; CAA44334.1; -; Genomic_DNA.
DR   PIR; S18143; S18143.
DR   RefSeq; NP_052325.1; NC_002117.1.
DR   RefSeq; WP_006343679.1; NZ_PJQA01000017.1.
DR   AlphaFoldDB; Q46258; -.
DR   SMR; Q46258; -.
DR   GeneID; 12242274; -.
DR   OMA; SEAIFIW; -.
DR   PRO; PR:Q46258; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.443.10; -; 1.
DR   InterPro; IPR044068; CB.
DR   InterPro; IPR011010; DNA_brk_join_enz.
DR   InterPro; IPR013762; Integrase-like_cat_sf.
DR   InterPro; IPR002104; Integrase_catalytic.
DR   Pfam; PF00589; Phage_integrase; 1.
DR   SUPFAM; SSF56349; SSF56349; 1.
DR   PROSITE; PS51900; CB; 1.
DR   PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE   3: Inferred from homology;
KW   DNA integration; DNA recombination; DNA-binding; Plasmid;
KW   Viral genome integration; Virus entry into host cell.
FT   CHAIN           1..335
FT                   /note="Virulence plasmid integrase pGP8-D"
FT                   /id="PRO_0000197565"
FT   DOMAIN          44..129
FT                   /note="Core-binding (CB)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01248"
FT   DOMAIN          155..332
FT                   /note="Tyr recombinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        194
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        219
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        284
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        287
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        310
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        319
FT                   /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
SQ   SEQUENCE   335 AA;  37937 MW;  B554CDDE0C6FFB2C CRC64;
     MRKGNSLHRN LDTIFGNEVY SNNLTHQEFL SVRNQHLWEK LRDIPLYEAV HTWLSSLTNH
     TSRSYRGSIL ALERIGLISL KMPLQQFALL NHNIILDAIK QIPTTVVCWS EGTKQVRAAC
     YISLTKFLNR VTSGIISIAQ PSHQESNKTF YKIRDLVKTN AMNQVERVLF LEELSKINYR
     DWLIAQTILQ GAKRVTEALS VTTDHICFEN GVISFNQIKS RGVFKTTIIT YPQKFMKLLQ
     DYVGERKGLV FITKKGRGVG LKQLAGTFAK AGIKAHIPFK VTPHVLRATA VTEYKKMGCS
     DSDIMKITGH SSSKMIYAYD KSTIADNASK KVSLI