ID   GP8D_CHLT2              Reviewed;         330 AA.
AC   B0BCM4; P08788; P10554;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Virulence plasmid integrase pGP8-D;
DE   AltName: Full=Protein N-1/N-2;
GN   OrderedLocusNames=pL2-02;
OS   Chlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B).
OG   Plasmid pL2, and Plasmid pLGV440.
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=471472;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   PLASMID=pLGV440;
RX   PubMed=2845228; DOI=10.1111/j.1365-2958.1988.tb00060.x;
RA   Comanducci M., Ricci S., Ratti G.;
RT   "The structure of a plasmid of Chlamydia trachomatis believed to be
RT   required for growth within mammalian cells.";
RL   Mol. Microbiol. 2:531-538(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=434/Bu / ATCC VR-902B; PLASMID=pL2;
RX   PubMed=18032721; DOI=10.1101/gr.7020108;
RA   Thomson N.R., Holden M.T.G., Carder C., Lennard N., Lockey S.J., Marsh P.,
RA   Skipp P., O'Connor C.D., Goodhead I., Norbertzcak H., Harris B., Ormond D.,
RA   Rance R., Quail M.A., Parkhill J., Stephens R.S., Clarke I.N.;
RT   "Chlamydia trachomatis: genome sequence analysis of lymphogranuloma
RT   venereum isolates.";
RL   Genome Res. 18:161-171(2008).
CC   -!- MISCELLANEOUS: pGP8-D is required for growth within mammalian cells.
CC   -!- SIMILARITY: Belongs to the 'phage' integrase family. {ECO:0000305}.
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DR   EMBL; X07547; CAA30420.1; -; Genomic_DNA.
DR   EMBL; AM886278; CAP09062.1; -; Genomic_DNA.
DR   PIR; H37386; H37386.
DR   RefSeq; NP_040381.1; NC_001372.1.
DR   RefSeq; YP_001654085.1; NC_010286.1.
DR   RefSeq; YP_002842023.1; NC_012625.1.
DR   RefSeq; YP_002842031.1; NC_012626.1.
DR   RefSeq; YP_002842039.1; NC_012627.1.
DR   AlphaFoldDB; B0BCM4; -.
DR   SMR; B0BCM4; -.
DR   OMA; SEAIFIW; -.
DR   Proteomes; UP000000795; Plasmid pL2.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.443.10; -; 1.
DR   InterPro; IPR044068; CB.
DR   InterPro; IPR011010; DNA_brk_join_enz.
DR   InterPro; IPR013762; Integrase-like_cat_sf.
DR   InterPro; IPR002104; Integrase_catalytic.
DR   Pfam; PF00589; Phage_integrase; 1.
DR   SUPFAM; SSF56349; SSF56349; 1.
DR   PROSITE; PS51900; CB; 1.
DR   PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE   3: Inferred from homology;
KW   DNA integration; DNA recombination; DNA-binding; Plasmid;
KW   Viral genome integration; Virus entry into host cell.
FT   CHAIN           1..330
FT                   /note="Virulence plasmid integrase pGP8-D"
FT                   /id="PRO_0000391803"
FT   DOMAIN          39..124
FT                   /note="Core-binding (CB)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01248"
FT   DOMAIN          152..327
FT                   /note="Tyr recombinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        189
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        214
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        279
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        282
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        305
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        314
FT                   /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
SQ   SEQUENCE   330 AA;  37791 MW;  A2E52C2C221FC1BB CRC64;
     MGKGILSLQQ EMSLEYSEKS YQEVLKIRQE SYWKRMKSFS LFEVIMHWTA SLNKHTCRSY
     RGSFLSLEKI GLLSLDMNLQ EFSLLNHNLI LDAIKKVSSA KTSWTEGTKQ VRAASYISLT
     RFLNRMTQGI VAIAQPSKQE NSRTFFKTRE IVKTDAMNSL QTASFLKELK KINARDWLIA
     QTMLQGGKRS SEVLSLEISQ ICFQQATISF SQLKNRQTEK RIIITYPQKF MHFLQEYIGQ
     RRGFVFVTRS GKMVGLRQIA RTFSQAGLQA AIPFKITPHV LRATAVTEYK RLGCSDSDIM
     KVTGHATAKM IFAYDKSSRE DNASKKMALI