ID   GP8D_CHLTH              Reviewed;         330 AA.
AC   P0CE20; P08788; P10554;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   02-MAR-2010, sequence version 1.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=Virulence plasmid integrase pGP8-D;
DE   AltName: Full=Protein N-1/N-2;
OS   Chlamydia trachomatis.
OG   Plasmid pLGV440, and Plasmid pCHL1.
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=813;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=L1/440/LN; PLASMID=pLGV440;
RX   PubMed=2836808; DOI=10.1093/nar/16.9.4053;
RA   Hatt C., Ward M.E., Clarke I.N.;
RT   "Analysis of the entire nucleotide sequence of the cryptic plasmid of
RT   Chlamydia trachomatis serovar L1. Evidence for involvement in DNA
RT   replication.";
RL   Nucleic Acids Res. 16:4053-4067(1988).
RN   [2]
RP   SEQUENCE REVISION.
RA   Hatt C.;
RL   Submitted (APR-1994) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=D/GO/86; PLASMID=pCHL1;
RX   PubMed=2194229; DOI=10.1016/0147-619x(90)90034-a;
RA   Comanducci M., Ricci S., Cevenini R., Ratti G.;
RT   "Diversity of the Chlamydia trachomatis common plasmid in biovars with
RT   different pathogenicity.";
RL   Plasmid 23:149-154(1990).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   PLASMID=pCHL1;
RX   PubMed=7683369; DOI=10.1007/bf00279434;
RA   Ricci S., Cevenini R., Cosco E., Comanducci M., Ratti G., Scarlato V.;
RT   "Transcriptional analysis of the Chlamydia trachomatis plasmid pCT
RT   identifies temporally regulated transcripts, anti-sense RNA and sigma 70-
RT   selected promoters.";
RL   Mol. Gen. Genet. 237:318-326(1993).
CC   -!- MISCELLANEOUS: pGP8-D is required for growth within mammalian cells.
CC   -!- SIMILARITY: Belongs to the 'phage' integrase family. {ECO:0000305}.
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DR   EMBL; X07547; CAA30420.1; -; Genomic_DNA.
DR   EMBL; X06707; CAA29891.2; -; Genomic_DNA.
DR   EMBL; J03321; AAA91568.1; -; Genomic_DNA.
DR   PIR; H37386; H37386.
DR   PIR; S01181; S01181.
DR   RefSeq; NP_040381.1; NC_001372.1.
DR   RefSeq; WP_010889883.1; NZ_CVNC01000027.1.
DR   RefSeq; YP_001569035.2; NC_010029.2.
DR   RefSeq; YP_001654085.1; NC_010286.1.
DR   RefSeq; YP_002842023.1; NC_012625.1.
DR   RefSeq; YP_002842031.1; NC_012626.1.
DR   RefSeq; YP_002842039.1; NC_012627.1.
DR   AlphaFoldDB; P0CE20; -.
DR   SMR; P0CE20; -.
DR   OMA; SEAIFIW; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.443.10; -; 1.
DR   InterPro; IPR044068; CB.
DR   InterPro; IPR011010; DNA_brk_join_enz.
DR   InterPro; IPR013762; Integrase-like_cat_sf.
DR   InterPro; IPR002104; Integrase_catalytic.
DR   Pfam; PF00589; Phage_integrase; 1.
DR   SUPFAM; SSF56349; SSF56349; 1.
DR   PROSITE; PS51900; CB; 1.
DR   PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE   3: Inferred from homology;
KW   DNA integration; DNA recombination; DNA-binding; Plasmid;
KW   Viral genome integration; Virus entry into host cell.
FT   CHAIN           1..330
FT                   /note="Virulence plasmid integrase pGP8-D"
FT                   /id="PRO_0000197566"
FT   DOMAIN          39..124
FT                   /note="Core-binding (CB)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01248"
FT   DOMAIN          152..327
FT                   /note="Tyr recombinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        189
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        214
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        279
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        282
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        305
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        314
FT                   /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
SQ   SEQUENCE   330 AA;  37791 MW;  A2E52C2C221FC1BB CRC64;
     MGKGILSLQQ EMSLEYSEKS YQEVLKIRQE SYWKRMKSFS LFEVIMHWTA SLNKHTCRSY
     RGSFLSLEKI GLLSLDMNLQ EFSLLNHNLI LDAIKKVSSA KTSWTEGTKQ VRAASYISLT
     RFLNRMTQGI VAIAQPSKQE NSRTFFKTRE IVKTDAMNSL QTASFLKELK KINARDWLIA
     QTMLQGGKRS SEVLSLEISQ ICFQQATISF SQLKNRQTEK RIIITYPQKF MHFLQEYIGQ
     RRGFVFVTRS GKMVGLRQIA RTFSQAGLQA AIPFKITPHV LRATAVTEYK RLGCSDSDIM
     KVTGHATAKM IFAYDKSSRE DNASKKMALI