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GPA4_CAEBR
ID   GPA4_CAEBR              Reviewed;         359 AA.
AC   Q61B55; A8XI06;
DT   27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Guanine nucleotide-binding protein alpha-4 subunit;
GN   Name=gpa-4; ORFNames=CBG13491;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=15856303; DOI=10.1007/s00438-004-1105-6;
RA   Jovelin R., Phillips P.C.;
RT   "Functional constraint and divergence in the G protein family in
RT   Caenorhabditis elegans and Caenorhabditis briggsae.";
RL   Mol. Genet. Genomics 273:299-310(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved
CC       as modulators or transducers in various transmembrane signaling
CC       systems.
CC   -!- SUBUNIT: G proteins are composed of 3 units; alpha, beta and gamma. The
CC       alpha chain contains the guanine nucleotide binding site.
CC   -!- SIMILARITY: Belongs to the G-alpha family. G(i/o/t/z) subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AY634297; AAW02903.1; -; Genomic_DNA.
DR   EMBL; HE600980; CAP32279.1; -; Genomic_DNA.
DR   RefSeq; XP_002634956.1; XM_002634910.1.
DR   AlphaFoldDB; Q61B55; -.
DR   SMR; Q61B55; -.
DR   STRING; 6238.CBG13491; -.
DR   EnsemblMetazoa; CBG13491.1; CBG13491.1; WBGene00034249.
DR   GeneID; 8576950; -.
DR   KEGG; cbr:CBG_13491; -.
DR   CTD; 8576950; -.
DR   WormBase; CBG13491; CBP17858; WBGene00034249; Cbr-gpa-4.
DR   eggNOG; KOG0082; Eukaryota.
DR   HOGENOM; CLU_014184_6_0_1; -.
DR   InParanoid; Q61B55; -.
DR   OMA; EYTGLNN; -.
DR   OrthoDB; 754573at2759; -.
DR   Proteomes; UP000008549; Chromosome IV.
DR   GO; GO:0005834; C:heterotrimeric G-protein complex; IBA:GO_Central.
DR   GO; GO:0097730; C:non-motile cilium; IEA:EnsemblMetazoa.
DR   GO; GO:0001664; F:G protein-coupled receptor binding; IBA:GO_Central.
DR   GO; GO:0031683; F:G-protein beta/gamma-subunit complex binding; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007188; P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   CDD; cd00066; G-alpha; 1.
DR   Gene3D; 1.10.400.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR001408; Gprotein_alpha_I.
DR   InterPro; IPR001019; Gprotein_alpha_su.
DR   InterPro; IPR011025; GproteinA_insert.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR10218; PTHR10218; 1.
DR   Pfam; PF00503; G-alpha; 1.
DR   PRINTS; PR00318; GPROTEINA.
DR   PRINTS; PR00441; GPROTEINAI.
DR   SMART; SM00275; G_alpha; 1.
DR   SUPFAM; SSF47895; SSF47895; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51882; G_ALPHA; 1.
PE   3: Inferred from homology;
KW   GTP-binding; Lipoprotein; Magnesium; Metal-binding; Myristate;
KW   Nucleotide-binding; Palmitate; Reference proteome; Transducer.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000255"
FT   CHAIN           2..359
FT                   /note="Guanine nucleotide-binding protein alpha-4 subunit"
FT                   /id="PRO_0000203634"
FT   DOMAIN          31..359
FT                   /note="G-alpha"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01230"
FT   REGION          34..47
FT                   /note="G1 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01230"
FT   REGION          176..184
FT                   /note="G2 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01230"
FT   REGION          199..208
FT                   /note="G3 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01230"
FT   REGION          268..275
FT                   /note="G4 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01230"
FT   REGION          329..334
FT                   /note="G5 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01230"
FT   BINDING         39..46
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         46
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
FT   BINDING         178..184
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         203..207
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         272..275
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         331
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   LIPID           2
FT                   /note="N-myristoyl glycine"
FT                   /evidence="ECO:0000255"
FT   LIPID           3
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   359 AA;  41699 MW;  E620775937EE90E2 CRC64;
     MGCVHSTGSE AKKRSQLIDA QLRLEHDQCG TEVKLLLLGA GESGKSTIVR QMRILHVIGF
     SKQEKLAYRA VIYSNMIQSM LVIIRVMKAL GIDFENSAHK EDAHQFSSHY LHIHNADLSE
     AFSLELSDLM KNLWSDAGVR RCFKRSREFQ LNDSTEYYFN SLDRISETTY LPTQDDILRA
     RVKSTGIVET DFMYKDIYFR MFDVGGQRSE RKKWIHCFEG VTAVIFCVAL SEYDMKLAED
     KIMNRMHESM QLFDSIVNNR WFTETSMILF LNKMDIFEEK IRHIPLNICF PEYKGGTSVT
     ETSNYIRSVF EKLNKRKSTA QKEVYSHFTC ATDTNNIRFV FDAVTDIIIR YNLKDCGLF
 
 
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