GPA9_CAEEL
ID GPA9_CAEEL Reviewed; 374 AA.
AC Q20910; G3MU18; G3MU19;
DT 27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 3.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Guanine nucleotide-binding protein alpha-9 subunit;
GN Name=gpa-9; ORFNames=F56H9.4;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=10192394; DOI=10.1038/7753;
RA Jansen G., Thijssen K.L., Werner P., van der Horst M., Hazendonk E.,
RA Plasterk R.H.A.;
RT "The complete family of genes encoding G proteins of Caenorhabditis
RT elegans.";
RL Nat. Genet. 21:414-419(1999).
CC -!- FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved
CC as modulators or transducers in various transmembrane signaling
CC systems.
CC -!- SUBUNIT: G proteins are composed of 3 units; alpha, beta and gamma. The
CC alpha chain contains the guanine nucleotide binding site.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=Q20910-1; Sequence=Displayed;
CC Name=b;
CC IsoId=Q20910-2; Sequence=VSP_044154;
CC -!- SIMILARITY: Belongs to the G-alpha family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; Z74473; CCD31081.1; -; Genomic_DNA.
DR EMBL; Z74473; CCD31082.1; -; Genomic_DNA.
DR PIR; T22810; T22810.
DR RefSeq; NP_001256444.1; NM_001269515.1. [Q20910-2]
DR AlphaFoldDB; Q20910; -.
DR SMR; Q20910; -.
DR STRING; 6239.F56H9.4a; -.
DR PaxDb; Q20910; -.
DR EnsemblMetazoa; F56H9.4b.1; F56H9.4b.1; WBGene00001671. [Q20910-2]
DR GeneID; 191659; -.
DR KEGG; cel:CELE_F56H9.4; -.
DR UCSC; F56H9.4; c. elegans. [Q20910-1]
DR CTD; 191659; -.
DR WormBase; F56H9.4a; CE46507; WBGene00001671; gpa-9.
DR WormBase; F56H9.4b; CE46135; WBGene00001671; gpa-9.
DR eggNOG; KOG0082; Eukaryota.
DR GeneTree; ENSGT00970000196357; -.
DR HOGENOM; CLU_014184_6_0_1; -.
DR InParanoid; Q20910; -.
DR OMA; KITHTNI; -.
DR OrthoDB; 754573at2759; -.
DR PhylomeDB; Q20910; -.
DR PRO; PR:Q20910; -.
DR Proteomes; UP000001940; Chromosome V.
DR GO; GO:0005834; C:heterotrimeric G-protein complex; IBA:GO_Central.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IBA:GO_Central.
DR GO; GO:0031683; F:G-protein beta/gamma-subunit complex binding; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007188; P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR CDD; cd00066; G-alpha; 1.
DR Gene3D; 1.10.400.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR001019; Gprotein_alpha_su.
DR InterPro; IPR011025; GproteinA_insert.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10218; PTHR10218; 1.
DR Pfam; PF00503; G-alpha; 1.
DR PRINTS; PR00318; GPROTEINA.
DR SMART; SM00275; G_alpha; 1.
DR SUPFAM; SSF47895; SSF47895; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51882; G_ALPHA; 1.
PE 3: Inferred from homology;
KW Alternative splicing; GTP-binding; Magnesium; Metal-binding;
KW Nucleotide-binding; Reference proteome; Transducer.
FT CHAIN 1..374
FT /note="Guanine nucleotide-binding protein alpha-9 subunit"
FT /id="PRO_0000203644"
FT DOMAIN 43..374
FT /note="G-alpha"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01230"
FT REGION 46..59
FT /note="G1 motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01230"
FT REGION 189..197
FT /note="G2 motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01230"
FT REGION 214..223
FT /note="G3 motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01230"
FT REGION 287..294
FT /note="G4 motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01230"
FT REGION 345..350
FT /note="G5 motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01230"
FT BINDING 51..58
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 58
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000250"
FT BINDING 191..197
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 197
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000250"
FT BINDING 218..222
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 291..294
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 347
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT VAR_SEQ 1..278
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_044154"
SQ SEQUENCE 374 AA; 43330 MW; F6CE5756AD460A89 CRC64;
MFSAESNLRN RWRLSKTLSE NIFLKIDENL KIETQILEER KKKALKLLII GPGESGKSTI
VKQVRILHCG GYSVEEKRAL KHGIYINILE GIDEIHWAIM WRQLIYENPS SIECLNQIRI
FTKQFNKTGE TENVLCKDII KSIQMYIKDE TVAMMLRNKT VYNIEDSTIH FIENLARVIG
KEYLPTGEDI LKTRVPTLGI AQYEANIKHL TFKFIFFDIG GQRAQRRKIT HLSGHVLDDS
HAILFITSLS EYNQVLREDA FVSRIEESLH LFNEICNGMY FHSTAIILFL NKIDLFEIKI
THTNITVAFP DYEGPRERDC ALEYIRVQFI SLNNNKNRKI YQHVTSATDT ARIQVVIDML
FDIIISASLK MVGV
