GPAN1_DROME
ID GPAN1_DROME Reviewed; 336 AA.
AC Q9V7A7; Q8SWS4;
DT 19-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=G patch domain and ankyrin repeat-containing protein 1 homolog;
GN ORFNames=CG8152;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000312|EMBL:AAM12288.1};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
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DR EMBL; AE013599; AAF58151.1; -; Genomic_DNA.
DR EMBL; AY095195; AAM12288.1; -; mRNA.
DR RefSeq; NP_611028.1; NM_137184.2.
DR AlphaFoldDB; Q9V7A7; -.
DR SMR; Q9V7A7; -.
DR BioGRID; 62433; 2.
DR IntAct; Q9V7A7; 2.
DR STRING; 7227.FBpp0086524; -.
DR PaxDb; Q9V7A7; -.
DR DNASU; 36696; -.
DR EnsemblMetazoa; FBtr0087392; FBpp0086524; FBgn0034008.
DR GeneID; 36696; -.
DR KEGG; dme:Dmel_CG8152; -.
DR UCSC; CG8152-RA; d. melanogaster.
DR FlyBase; FBgn0034008; CG8152.
DR VEuPathDB; VectorBase:FBgn0034008; -.
DR eggNOG; KOG2384; Eukaryota.
DR GeneTree; ENSGT00390000003292; -.
DR HOGENOM; CLU_048068_2_0_1; -.
DR InParanoid; Q9V7A7; -.
DR OMA; QGWDQEH; -.
DR OrthoDB; 1271730at2759; -.
DR PhylomeDB; Q9V7A7; -.
DR BioGRID-ORCS; 36696; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 36696; -.
DR PRO; PR:Q9V7A7; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0034008; Expressed in secondary oocyte and 26 other tissues.
DR ExpressionAtlas; Q9V7A7; baseline and differential.
DR Genevisible; Q9V7A7; DM.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR000467; G_patch_dom.
DR InterPro; IPR039146; GPANK1.
DR PANTHER; PTHR20923; PTHR20923; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01585; G-patch; 1.
DR SMART; SM00248; ANK; 2.
DR SMART; SM00443; G_patch; 1.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50174; G_PATCH; 1.
PE 2: Evidence at transcript level;
KW ANK repeat; Reference proteome; Repeat.
FT CHAIN 1..336
FT /note="G patch domain and ankyrin repeat-containing protein
FT 1 homolog"
FT /id="PRO_0000066975"
FT REPEAT 123..152
FT /note="ANK 1"
FT /evidence="ECO:0000305"
FT REPEAT 156..185
FT /note="ANK 2"
FT /evidence="ECO:0000305"
FT DOMAIN 240..286
FT /note="G-patch"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00092"
FT CONFLICT 208
FT /note="K -> E (in Ref. 3; AAM12288)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 336 AA; 38523 MW; 7C1DBAFC8594DE28 CRC64;
MNSQNELHPN WLALTTLPLQ LKRFVRAGDP DFIAESPKAV KHQIDGLNGA EAREFYKEVL
DAPTTCQPNL PSTHKTAQTR REPERILVPF DKSKFFRLAT SNKVEELSQM KASEEDLNSR
DSFGWTALMM AACEGATEAV SWLVQRGVQV ETSDKSGNTA LKLAQRKGHL DVVHLLESLP
ILEETSEEDE SVDGNNPFYC EICKRDYKET PWPIHQTSTV HQFNLKALPA HKLHKFNISA
KNRGLQLMVK QGWDQEHGLG PSQSGRLYPV KTVLRKQRTG LGIEQQSARV SHFGAFDLNA
VRRRDPIYQP RRTRSDMQRE KVREWKRERY LRRVLS
