GPAN1_HUMAN
ID GPAN1_HUMAN Reviewed; 356 AA.
AC O95872; A6NG25; B0UXA2; Q5SQ49;
DT 25-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 172.
DE RecName: Full=G patch domain and ankyrin repeat-containing protein 1;
DE AltName: Full=Ankyrin repeat domain-containing protein 59;
DE AltName: Full=G patch domain-containing protein 10;
DE AltName: Full=HLA-B-associated transcript 4;
DE AltName: Full=Protein G5;
GN Name=GPANK1; Synonyms=ANKRD59, BAT4, G5, GPATCH10;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14656967; DOI=10.1101/gr.1736803;
RA Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D.,
RA Hood L.;
RT "Analysis of the gene-dense major histocompatibility complex class III
RT region and its comparison to mouse.";
RL Genome Res. 13:2621-2636(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Shiina S., Tamiya G., Oka A., Inoko H.;
RT "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region.";
RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT LEU-41.
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [7]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-290, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
RN [8]
RP VARIANT ASN-314.
RX PubMed=21248752; DOI=10.1038/nature09639;
RA Varela I., Tarpey P., Raine K., Huang D., Ong C.K., Stephens P., Davies H.,
RA Jones D., Lin M.L., Teague J., Bignell G., Butler A., Cho J.,
RA Dalgliesh G.L., Galappaththige D., Greenman C., Hardy C., Jia M.,
RA Latimer C., Lau K.W., Marshall J., McLaren S., Menzies A., Mudie L.,
RA Stebbings L., Largaespada D.A., Wessels L.F.A., Richard S., Kahnoski R.J.,
RA Anema J., Tuveson D.A., Perez-Mancera P.A., Mustonen V., Fischer A.,
RA Adams D.J., Rust A., Chan-On W., Subimerb C., Dykema K., Furge K.,
RA Campbell P.J., Teh B.T., Stratton M.R., Futreal P.A.;
RT "Exome sequencing identifies frequent mutation of the SWI/SNF complex gene
RT PBRM1 in renal carcinoma.";
RL Nature 469:539-542(2011).
CC -!- INTERACTION:
CC O95872; Q9NYB9-2: ABI2; NbExp=3; IntAct=EBI-751540, EBI-11096309;
CC O95872; Q9ULX6: AKAP8L; NbExp=3; IntAct=EBI-751540, EBI-357530;
CC O95872; Q9NYG5-2: ANAPC11; NbExp=3; IntAct=EBI-751540, EBI-12224467;
CC O95872; Q10567-3: AP1B1; NbExp=3; IntAct=EBI-751540, EBI-11978055;
CC O95872; P63010-2: AP2B1; NbExp=3; IntAct=EBI-751540, EBI-11529439;
CC O95872; O95429: BAG4; NbExp=3; IntAct=EBI-751540, EBI-2949658;
CC O95872; Q6PI77: BHLHB9; NbExp=3; IntAct=EBI-751540, EBI-11519926;
CC O95872; Q9BXJ5: C1QTNF2; NbExp=3; IntAct=EBI-751540, EBI-2817707;
CC O95872; A2RRN7: CADPS; NbExp=3; IntAct=EBI-751540, EBI-10179719;
CC O95872; Q52MB2: CCDC184; NbExp=6; IntAct=EBI-751540, EBI-10179526;
CC O95872; P40199: CEACAM6; NbExp=3; IntAct=EBI-751540, EBI-4314501;
CC O95872; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-751540, EBI-3867333;
CC O95872; Q8WTU0: DDI1; NbExp=3; IntAct=EBI-751540, EBI-748248;
CC O95872; O43143: DHX15; NbExp=3; IntAct=EBI-751540, EBI-1237044;
CC O95872; Q9NRI5-2: DISC1; NbExp=3; IntAct=EBI-751540, EBI-11988027;
CC O95872; Q16610: ECM1; NbExp=3; IntAct=EBI-751540, EBI-947964;
CC O95872; O43281-2: EFS; NbExp=3; IntAct=EBI-751540, EBI-11525448;
CC O95872; A8MTA8-2: FAM166B; NbExp=3; IntAct=EBI-751540, EBI-12160437;
CC O95872; Q9C0B1-2: FTO; NbExp=3; IntAct=EBI-751540, EBI-18138793;
CC O95872; Q08379: GOLGA2; NbExp=4; IntAct=EBI-751540, EBI-618309;
CC O95872; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-751540, EBI-5916454;
CC O95872; P31943: HNRNPH1; NbExp=3; IntAct=EBI-751540, EBI-351590;
CC O95872; O75031: HSF2BP; NbExp=3; IntAct=EBI-751540, EBI-7116203;
CC O95872; P04792: HSPB1; NbExp=3; IntAct=EBI-751540, EBI-352682;
CC O95872; Q96EL1: INKA1; NbExp=3; IntAct=EBI-751540, EBI-10285157;
CC O95872; Q1MX18: INSC; NbExp=3; IntAct=EBI-751540, EBI-12081118;
CC O95872; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-751540, EBI-2556193;
CC O95872; Q9H079: KATNBL1; NbExp=3; IntAct=EBI-751540, EBI-715394;
CC O95872; Q7L273: KCTD9; NbExp=3; IntAct=EBI-751540, EBI-4397613;
CC O95872; O60333-2: KIF1B; NbExp=3; IntAct=EBI-751540, EBI-10975473;
CC O95872; O95678: KRT75; NbExp=3; IntAct=EBI-751540, EBI-2949715;
CC O95872; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-751540, EBI-10171774;
CC O95872; P59991: KRTAP12-2; NbExp=3; IntAct=EBI-751540, EBI-10176379;
CC O95872; Q3SY46: KRTAP13-3; NbExp=3; IntAct=EBI-751540, EBI-10241252;
CC O95872; Q3LI72: KRTAP19-5; NbExp=3; IntAct=EBI-751540, EBI-1048945;
CC O95872; Q3LI70: KRTAP19-6; NbExp=3; IntAct=EBI-751540, EBI-12805508;
CC O95872; O95751: LDOC1; NbExp=3; IntAct=EBI-751540, EBI-740738;
CC O95872; Q9BRK4: LZTS2; NbExp=4; IntAct=EBI-751540, EBI-741037;
CC O95872; Q9Y5V3: MAGED1; NbExp=3; IntAct=EBI-751540, EBI-716006;
CC O95872; Q96A72: MAGOHB; NbExp=3; IntAct=EBI-751540, EBI-746778;
CC O95872; Q99750: MDFI; NbExp=3; IntAct=EBI-751540, EBI-724076;
CC O95872; P50221: MEOX1; NbExp=3; IntAct=EBI-751540, EBI-2864512;
CC O95872; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-751540, EBI-16439278;
CC O95872; Q8N6F8: METTL27; NbExp=3; IntAct=EBI-751540, EBI-8487781;
CC O95872; Q8TCB7: METTL6; NbExp=3; IntAct=EBI-751540, EBI-17861723;
CC O95872; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-751540, EBI-10172526;
CC O95872; Q6PF18: MORN3; NbExp=3; IntAct=EBI-751540, EBI-9675802;
CC O95872; Q6IA69: NADSYN1; NbExp=3; IntAct=EBI-751540, EBI-748610;
CC O95872; Q8NI38: NFKBID; NbExp=3; IntAct=EBI-751540, EBI-10271199;
CC O95872; Q13133-3: NR1H3; NbExp=3; IntAct=EBI-751540, EBI-11952806;
CC O95872; O43482: OIP5; NbExp=3; IntAct=EBI-751540, EBI-536879;
CC O95872; Q96CV9: OPTN; NbExp=3; IntAct=EBI-751540, EBI-748974;
CC O95872; Q9HBE1-4: PATZ1; NbExp=3; IntAct=EBI-751540, EBI-11022007;
CC O95872; P26367: PAX6; NbExp=3; IntAct=EBI-751540, EBI-747278;
CC O95872; Q9BYU1: PBX4; NbExp=3; IntAct=EBI-751540, EBI-10302990;
CC O95872; Q99471: PFDN5; NbExp=3; IntAct=EBI-751540, EBI-357275;
CC O95872; Q9HDD0: PLAAT1; NbExp=3; IntAct=EBI-751540, EBI-12387058;
CC O95872; Q8ND90: PNMA1; NbExp=4; IntAct=EBI-751540, EBI-302345;
CC O95872; P60510: PPP4C; NbExp=3; IntAct=EBI-751540, EBI-1046072;
CC O95872; Q9NQX0: PRDM6; NbExp=3; IntAct=EBI-751540, EBI-11320284;
CC O95872; Q03431: PTH1R; NbExp=3; IntAct=EBI-751540, EBI-2860297;
CC O95872; Q9UFD9: RIMBP3; NbExp=3; IntAct=EBI-751540, EBI-10182375;
CC O95872; Q9Y3C5: RNF11; NbExp=3; IntAct=EBI-751540, EBI-396669;
CC O95872; A6ZKI3: RTL8C; NbExp=3; IntAct=EBI-751540, EBI-10174072;
CC O95872; O60504: SORBS3; NbExp=3; IntAct=EBI-751540, EBI-741237;
CC O95872; Q9UM82: SPATA2; NbExp=3; IntAct=EBI-751540, EBI-744066;
CC O95872; Q9NZ72: STMN3; NbExp=3; IntAct=EBI-751540, EBI-725557;
CC O95872; Q13190: STX5; NbExp=3; IntAct=EBI-751540, EBI-714206;
CC O95872; Q96N21: TEPSIN; NbExp=3; IntAct=EBI-751540, EBI-11139477;
CC O95872; Q12800: TFCP2; NbExp=3; IntAct=EBI-751540, EBI-717422;
CC O95872; Q08117-2: TLE5; NbExp=3; IntAct=EBI-751540, EBI-11741437;
CC O95872; Q12933: TRAF2; NbExp=3; IntAct=EBI-751540, EBI-355744;
CC O95872; Q9UL33-2: TRAPPC2L; NbExp=3; IntAct=EBI-751540, EBI-11119202;
CC O95872; P36406: TRIM23; NbExp=7; IntAct=EBI-751540, EBI-740098;
CC O95872; P14373: TRIM27; NbExp=7; IntAct=EBI-751540, EBI-719493;
CC O95872; Q86WV8: TSC1; NbExp=5; IntAct=EBI-751540, EBI-12806590;
CC O95872; Q6DKK2: TTC19; NbExp=4; IntAct=EBI-751540, EBI-948354;
CC O95872; Q5W5X9-3: TTC23; NbExp=3; IntAct=EBI-751540, EBI-9090990;
CC O95872; P61758: VBP1; NbExp=3; IntAct=EBI-751540, EBI-357430;
CC O95872; O76024: WFS1; NbExp=3; IntAct=EBI-751540, EBI-720609;
CC O95872; Q05516: ZBTB16; NbExp=3; IntAct=EBI-751540, EBI-711925;
CC O95872; Q8IWT0-2: ZBTB8OS; NbExp=3; IntAct=EBI-751540, EBI-12956041;
CC O95872; Q9UDW3: ZMAT5; NbExp=3; IntAct=EBI-751540, EBI-7850213;
CC O95872; P0C7X2: ZNF688; NbExp=3; IntAct=EBI-751540, EBI-4395732;
CC O95872; Q9UGI0: ZRANB1; NbExp=3; IntAct=EBI-751540, EBI-527853;
CC O95872; G4XUV3; NbExp=3; IntAct=EBI-751540, EBI-10177989;
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DR EMBL; AF129756; AAD18082.1; -; Genomic_DNA.
DR EMBL; BA000025; BAB63387.1; -; Genomic_DNA.
DR EMBL; AL670886; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL805934; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL662899; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX511262; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR354443; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR759761; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471081; EAX03467.1; -; Genomic_DNA.
DR EMBL; BC008783; AAH08783.1; -; mRNA.
DR CCDS; CCDS4711.1; -.
DR RefSeq; NP_001186166.1; NM_001199237.1.
DR RefSeq; NP_001186167.1; NM_001199238.1.
DR RefSeq; NP_001186168.1; NM_001199239.1.
DR RefSeq; NP_001186169.1; NM_001199240.1.
DR RefSeq; NP_149417.1; NM_033177.3.
DR RefSeq; XP_005249460.1; XM_005249403.3.
DR RefSeq; XP_006715267.1; XM_006715204.1.
DR RefSeq; XP_011513211.1; XM_011514909.1.
DR RefSeq; XP_011513212.1; XM_011514910.1.
DR AlphaFoldDB; O95872; -.
DR SMR; O95872; -.
DR BioGRID; 113648; 99.
DR IntAct; O95872; 94.
DR MINT; O95872; -.
DR STRING; 9606.ENSP00000365071; -.
DR iPTMnet; O95872; -.
DR PhosphoSitePlus; O95872; -.
DR BioMuta; GPANK1; -.
DR EPD; O95872; -.
DR jPOST; O95872; -.
DR MassIVE; O95872; -.
DR MaxQB; O95872; -.
DR PaxDb; O95872; -.
DR PeptideAtlas; O95872; -.
DR PRIDE; O95872; -.
DR ProteomicsDB; 51112; -.
DR Antibodypedia; 27457; 63 antibodies from 21 providers.
DR DNASU; 7918; -.
DR Ensembl; ENST00000211377.7; ENSP00000211377.3; ENSG00000236011.6.
DR Ensembl; ENST00000375893.6; ENSP00000365057.2; ENSG00000204438.11.
DR Ensembl; ENST00000375895.6; ENSP00000365059.2; ENSG00000204438.11.
DR Ensembl; ENST00000375896.9; ENSP00000365060.4; ENSG00000204438.11.
DR Ensembl; ENST00000375900.8; ENSP00000365065.4; ENSG00000204438.11.
DR Ensembl; ENST00000375906.5; ENSP00000365071.1; ENSG00000204438.11.
DR Ensembl; ENST00000383434.6; ENSP00000372926.2; ENSG00000206408.8.
DR Ensembl; ENST00000383436.8; ENSP00000372928.4; ENSG00000206408.8.
DR Ensembl; ENST00000400129.7; ENSP00000382994.3; ENSG00000206408.8.
DR Ensembl; ENST00000400134.5; ENSP00000382999.1; ENSG00000206408.8.
DR Ensembl; ENST00000400139.5; ENSP00000383005.1; ENSG00000206408.8.
DR Ensembl; ENST00000414528.6; ENSP00000389339.2; ENSG00000228605.6.
DR Ensembl; ENST00000416384.5; ENSP00000401376.1; ENSG00000223932.6.
DR Ensembl; ENST00000417890.6; ENSP00000415855.2; ENSG00000232312.6.
DR Ensembl; ENST00000418502.6; ENSP00000412321.2; ENSG00000223932.6.
DR Ensembl; ENST00000422131.6; ENSP00000410690.2; ENSG00000223932.6.
DR Ensembl; ENST00000426326.6; ENSP00000398927.2; ENSG00000228605.6.
DR Ensembl; ENST00000427527.5; ENSP00000391604.1; ENSG00000236011.6.
DR Ensembl; ENST00000429266.5; ENSP00000412884.1; ENSG00000223932.6.
DR Ensembl; ENST00000433857.6; ENSP00000406895.2; ENSG00000236011.6.
DR Ensembl; ENST00000433880.5; ENSP00000401272.1; ENSG00000228605.6.
DR Ensembl; ENST00000439710.5; ENSP00000409206.1; ENSG00000232312.6.
DR Ensembl; ENST00000440777.5; ENSP00000399890.1; ENSG00000223932.6.
DR Ensembl; ENST00000447705.6; ENSP00000403829.2; ENSG00000236011.6.
DR Ensembl; ENST00000448091.5; ENSP00000411691.1; ENSG00000232312.6.
DR Ensembl; ENST00000449868.6; ENSP00000393567.2; ENSG00000232312.6.
DR Ensembl; ENST00000453746.5; ENSP00000390746.1; ENSG00000232312.6.
DR Ensembl; ENST00000453899.5; ENSP00000413662.1; ENSG00000228605.6.
DR Ensembl; ENST00000456191.5; ENSP00000401276.1; ENSG00000236011.6.
DR Ensembl; ENST00000457505.5; ENSP00000406507.1; ENSG00000228605.6.
DR GeneID; 7918; -.
DR KEGG; hsa:7918; -.
DR MANE-Select; ENST00000375896.9; ENSP00000365060.4; NM_033177.4; NP_149417.1.
DR UCSC; uc003nvn.4; human.
DR CTD; 7918; -.
DR DisGeNET; 7918; -.
DR GeneCards; GPANK1; -.
DR HGNC; HGNC:13920; GPANK1.
DR HPA; ENSG00000204438; Low tissue specificity.
DR MIM; 142610; gene.
DR neXtProt; NX_O95872; -.
DR OpenTargets; ENSG00000204438; -.
DR PharmGKB; PA25265; -.
DR VEuPathDB; HostDB:ENSG00000204438; -.
DR eggNOG; KOG2384; Eukaryota.
DR GeneTree; ENSGT00390000003292; -.
DR HOGENOM; CLU_048068_0_0_1; -.
DR InParanoid; O95872; -.
DR OMA; QGWDQEH; -.
DR OrthoDB; 1271730at2759; -.
DR PhylomeDB; O95872; -.
DR TreeFam; TF315384; -.
DR PathwayCommons; O95872; -.
DR SignaLink; O95872; -.
DR BioGRID-ORCS; 7918; 11 hits in 1065 CRISPR screens.
DR ChiTaRS; GPANK1; human.
DR GeneWiki; BAT4; -.
DR GenomeRNAi; 7918; -.
DR Pharos; O95872; Tdark.
DR PRO; PR:O95872; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; O95872; protein.
DR Bgee; ENSG00000204438; Expressed in left testis and 98 other tissues.
DR ExpressionAtlas; O95872; baseline and differential.
DR Genevisible; O95872; HS.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR000467; G_patch_dom.
DR InterPro; IPR039146; GPANK1.
DR PANTHER; PTHR20923; PTHR20923; 1.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF01585; G-patch; 1.
DR SMART; SM00443; G_patch; 1.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50174; G_PATCH; 1.
PE 1: Evidence at protein level;
KW ANK repeat; Isopeptide bond; Reference proteome; Repeat; Ubl conjugation.
FT CHAIN 1..356
FT /note="G patch domain and ankyrin repeat-containing protein
FT 1"
FT /id="PRO_0000066972"
FT REPEAT 111..141
FT /note="ANK 1"
FT REPEAT 142..172
FT /note="ANK 2"
FT DOMAIN 255..301
FT /note="G-patch"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00092"
FT REGION 1..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..31
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 290
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VARIANT 41
FT /note="R -> L (in dbSNP:rs3130618)"
FT /evidence="ECO:0000269|PubMed:14574404"
FT /id="VAR_048291"
FT VARIANT 112
FT /note="A -> V (in dbSNP:rs35265780)"
FT /id="VAR_048292"
FT VARIANT 210
FT /note="S -> A (in dbSNP:rs34082689)"
FT /id="VAR_048293"
FT VARIANT 235
FT /note="A -> V (in dbSNP:rs2295666)"
FT /id="VAR_020096"
FT VARIANT 314
FT /note="T -> N (found in a clear cell renal carcinoma case;
FT somatic mutation)"
FT /evidence="ECO:0000269|PubMed:21248752"
FT /id="VAR_064698"
SQ SEQUENCE 356 AA; 39314 MW; AA57AA938A8C10E5 CRC64;
MSRPLLITFT PATDPSDLWK DGQQQPQPEK PESTLDGAAA RAFYEALIGD ESSAPDSQRS
QTEPARERKR KKRRIMKAPA AEAVAEGASG RHGQGRSLEA EDKMTHRILR AAQEGDLPEL
RRLLEPHEAG GAGGNINARD AFWWTPLMCA ARAGQGAAVS YLLGRGAAWV GVCELSGRDA
AQLAEEAGFP EVARMVRESH GETRSPENRS PTPSLQYCEN CDTHFQDSNH RTSTAHLLSL
SQGPQPPNLP LGVPISSPGF KLLLRGGWEP GMGLGPRGEG RANPIPTVLK RDQEGLGYRS
APQPRVTHFP AWDTRAVAGR ERPPRVATLS WREERRREEK DRAWERDLRT YMNLEF
