GPBAR_MOUSE
ID GPBAR_MOUSE Reviewed; 329 AA.
AC Q80SS6;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=G-protein coupled bile acid receptor 1;
DE AltName: Full=Membrane-type receptor for bile acids;
DE Short=M-BAR;
GN Name=Gpbar1; Synonyms=Tgr5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12419312; DOI=10.1016/s0006-291x(02)02550-0;
RA Maruyama T., Miyamoto Y., Nakamura T., Tamai Y., Okada H., Sugiyama E.,
RA Nakamura T., Itadani H., Tanaka K.;
RT "Identification of membrane-type receptor for bile acids (M-BAR).";
RL Biochem. Biophys. Res. Commun. 298:714-719(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12524422; DOI=10.1074/jbc.m209706200;
RA Kawamata Y., Fujii R., Hosoya M., Harada M., Yoshida H., Miwa M.,
RA Fukusumi S., Habata Y., Itoh T., Shintani Y., Hinuma S., Fujisawa Y.,
RA Fujino M.;
RT "A G protein-coupled receptor responsive to bile acids.";
RL J. Biol. Chem. 278:9435-9440(2003).
RN [3]
RP FUNCTION.
RX PubMed=15721318; DOI=10.1016/j.bbrc.2005.01.139;
RA Katsuma S., Hirasawa A., Tsujimoto G.;
RT "Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a
RT murine enteroendocrine cell line STC-1.";
RL Biochem. Biophys. Res. Commun. 329:386-390(2005).
CC -!- FUNCTION: Receptor for bile acid. Bile acid-binding induces its
CC internalization, activation of extracellular signal-regulated kinase
CC and intracellular cAMP production. May be involved in the suppression
CC of macrophage functions by bile acids (By similarity). Involved in bile
CC acid promoted GLP1R secretion. {ECO:0000250,
CC ECO:0000269|PubMed:15721318}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AB086171; BAC65344.1; -; mRNA.
DR EMBL; AB089308; BAC55236.1; -; mRNA.
DR CCDS; CCDS15042.1; -.
DR RefSeq; NP_778150.1; NM_174985.1.
DR AlphaFoldDB; Q80SS6; -.
DR SMR; Q80SS6; -.
DR STRING; 10090.ENSMUSP00000077135; -.
DR BindingDB; Q80SS6; -.
DR ChEMBL; CHEMBL1255150; -.
DR GuidetoPHARMACOLOGY; 37; -.
DR GlyGen; Q80SS6; 2 sites.
DR PaxDb; Q80SS6; -.
DR PRIDE; Q80SS6; -.
DR Antibodypedia; 34258; 315 antibodies from 31 providers.
DR DNASU; 227289; -.
DR Ensembl; ENSMUST00000077985; ENSMUSP00000077135; ENSMUSG00000064272.
DR GeneID; 227289; -.
DR KEGG; mmu:227289; -.
DR UCSC; uc007blq.1; mouse.
DR CTD; 151306; -.
DR MGI; MGI:2653863; Gpbar1.
DR VEuPathDB; HostDB:ENSMUSG00000064272; -.
DR eggNOG; ENOG502SQ0C; Eukaryota.
DR GeneTree; ENSGT00390000010256; -.
DR HOGENOM; CLU_895831_0_0_1; -.
DR InParanoid; Q80SS6; -.
DR OMA; KDICRLH; -.
DR OrthoDB; 1173007at2759; -.
DR PhylomeDB; Q80SS6; -.
DR TreeFam; TF333321; -.
DR Reactome; R-MMU-373076; Class A/1 (Rhodopsin-like receptors).
DR Reactome; R-MMU-418555; G alpha (s) signalling events.
DR BioGRID-ORCS; 227289; 1 hit in 70 CRISPR screens.
DR PRO; PR:Q80SS6; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q80SS6; protein.
DR Bgee; ENSMUSG00000064272; Expressed in yolk sac and 19 other tissues.
DR ExpressionAtlas; Q80SS6; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0043235; C:receptor complex; ISO:MGI.
DR GO; GO:0038181; F:bile acid receptor activity; ISO:MGI.
DR GO; GO:0038182; F:G protein-coupled bile acid receptor activity; ISO:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; ISO:MGI.
DR GO; GO:0038184; P:cell surface bile acid receptor signaling pathway; ISO:MGI.
DR GO; GO:1903413; P:cellular response to bile acid; ISO:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:1904056; P:positive regulation of cholangiocyte proliferation; ISO:MGI.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISO:MGI.
DR GO; GO:2000810; P:regulation of bicellular tight junction assembly; IMP:CACAO.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..329
FT /note="G-protein coupled bile acid receptor 1"
FT /id="PRO_0000069501"
FT TOPO_DOM 1..15
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 16..36
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 37..49
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..70
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 71..84
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..105
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 106..124
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..145
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 146..164
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..185
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 186..229
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 230..250
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 251..260
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 261..281
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 282..329
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 153
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 84..154
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 329 AA; 35650 MW; F6F55527EB9C075F CRC64;
MMTPNSTELS AIPMGVLGLS LALASLIVIA NLLLALGIAL DRHLRSPPAG CFFLSLLLAG
LLTGLALPML PGLWSRNHQG YWSCLLLHLT PNFCFLSLLA NLLLVHGERY MAVLQPLRPH
GSVRLALFLT WVSSLFFASL PALGWNHWSP DANCSSQAVF PAPYLYLEVY GLLLPAVGAT
ALLSVRVLAT AHRQLCEIRR LERAVCRDVP STLARALTWR QARAQAGATL LFLLCWGPYV
ATLLLSVLAY ERRPPLGPGT LLSLISLGST SAAAVPVAMG LGDQRYTAPW RTAAQRCLRV
LRGRAKRDNP GPSTAYHTSS QCSIDLDLN
