GPBL1_MOUSE
ID GPBL1_MOUSE Reviewed; 473 AA.
AC Q6NZP2; Q8BHW7; Q8BI03; Q8K2H8; Q9CTV6;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Vasculin-like protein 1;
DE AltName: Full=GC-rich promoter-binding protein 1-like 1;
GN Name=Gpbp1l1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo, Pituitary, Skin, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and Czech II; TISSUE=Brain, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-76, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49 AND SER-289, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Kidney, Lung, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Possible transcription factor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the vasculin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC36644.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK019942; BAB31926.1; -; mRNA.
DR EMBL; AK037224; BAC29763.1; -; mRNA.
DR EMBL; AK077148; BAC36644.1; ALT_SEQ; mRNA.
DR EMBL; AK133761; BAE21827.1; -; mRNA.
DR EMBL; BC031428; AAH31428.1; -; mRNA.
DR EMBL; BC066034; AAH66034.1; -; mRNA.
DR CCDS; CCDS18511.1; -.
DR RefSeq; NP_084144.2; NM_029868.2.
DR RefSeq; XP_006503548.1; XM_006503485.3.
DR RefSeq; XP_017175941.1; XM_017320452.1.
DR AlphaFoldDB; Q6NZP2; -.
DR BioGRID; 218520; 3.
DR STRING; 10090.ENSMUSP00000030460; -.
DR iPTMnet; Q6NZP2; -.
DR PhosphoSitePlus; Q6NZP2; -.
DR EPD; Q6NZP2; -.
DR jPOST; Q6NZP2; -.
DR MaxQB; Q6NZP2; -.
DR PaxDb; Q6NZP2; -.
DR PRIDE; Q6NZP2; -.
DR ProteomicsDB; 271313; -.
DR Antibodypedia; 32691; 59 antibodies from 18 providers.
DR Ensembl; ENSMUST00000030460; ENSMUSP00000030460; ENSMUSG00000034042.
DR Ensembl; ENSMUST00000106475; ENSMUSP00000102083; ENSMUSG00000034042.
DR GeneID; 77110; -.
DR KEGG; mmu:77110; -.
DR UCSC; uc008ugr.1; mouse.
DR CTD; 60313; -.
DR MGI; MGI:1924360; Gpbp1l1.
DR VEuPathDB; HostDB:ENSMUSG00000034042; -.
DR eggNOG; ENOG502QPN2; Eukaryota.
DR GeneTree; ENSGT00420000029753; -.
DR HOGENOM; CLU_045487_0_0_1; -.
DR InParanoid; Q6NZP2; -.
DR OMA; CWHQPSL; -.
DR OrthoDB; 662557at2759; -.
DR PhylomeDB; Q6NZP2; -.
DR TreeFam; TF332220; -.
DR BioGRID-ORCS; 77110; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Gpbp1l1; mouse.
DR PRO; PR:Q6NZP2; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q6NZP2; protein.
DR Bgee; ENSMUSG00000034042; Expressed in spermatocyte and 61 other tissues.
DR Genevisible; Q6NZP2; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR028128; Vasculin_fam.
DR PANTHER; PTHR14339; PTHR14339; 1.
DR Pfam; PF15337; Vasculin; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..473
FT /note="Vasculin-like protein 1"
FT /id="PRO_0000324116"
FT REGION 14..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 88..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 155..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 235..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 281..316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 453..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..46
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..117
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..310
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 49
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 76
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19144319"
FT MOD_RES 199
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9HC44"
FT MOD_RES 289
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 298
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9HC44"
FT MOD_RES 381
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9HC44"
FT CONFLICT 138
FT /note="R -> G (in Ref. 1; BAC29763)"
FT /evidence="ECO:0000305"
FT CONFLICT 377
FT /note="G -> R (in Ref. 2; AAH31428)"
FT /evidence="ECO:0000305"
FT CONFLICT 441
FT /note="S -> N (in Ref. 2; AAH31428)"
FT /evidence="ECO:0000305"
FT CONFLICT 459
FT /note="S -> T (in Ref. 2; AAH31428)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 473 AA; 51966 MW; E73CEE25CC905B5C CRC64;
MAQHDFVPAW LNFSTPQSSK SSTATFDKHG EHLSRGEGRF GISRRRHNSS DGFFNNGPLR
TTGDSWHQPS LFRHDSVDSG VSKGAYAGTT GWHGSSRGHD GMSQRSGGSS TGNHRHWNGS
FHSRKGCAFQ EKTPTEIREE KKEDKVEKLQ FEEEDFPSLN PEAGKQNQPC RPVGTPSGVW
ENPPSAKQPS KMLVIKKISK EDPAAAFSAA FTSSGSHHAN GNKVSTMVPS VYKNLVPKPA
PPPSKPNAWK ANRTEHKPGS LCSSRESAFT NPISVTKPVG LAAGAGLHSP KESPSSTTPP
IEISSSRLTK LTRRTTDRKS EFLKTLKDER NGDCSESRDC DKLEGLRLEG SHTPEPKENG
EQGCLQNGLS LPMVEEGEVL SHSLEAEHRL LKAMGWQEYP ENDESCLPLT EDELKEFHLR
TEQLRRNGFG KNGLLQSRSC SLSSPWRSTC IAECEDSDSE TSSSQTSDDD AWK
