ID   GPBP1_BOVIN             Reviewed;         473 AA.
AC   Q0P5K1;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Vasculin;
DE   AltName: Full=GC-rich promoter-binding protein 1;
GN   Name=GPBP1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Basal ganglia;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions as a GC-rich promoter-specific transactivating
CC       transcription factor. {ECO:0000250|UniProtKB:Q6NXH3}.
CC   -!- SUBUNIT: Interacts with GTF2B, GTF2F2, RNA polymerase II and TBP.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6NXH3}.
CC   -!- SIMILARITY: Belongs to the vasculin family. {ECO:0000305}.
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DR   EMBL; BC119942; AAI19943.1; -; mRNA.
DR   RefSeq; NP_001069755.1; NM_001076287.1.
DR   RefSeq; XP_005221560.1; XM_005221503.2.
DR   AlphaFoldDB; Q0P5K1; -.
DR   STRING; 9913.ENSBTAP00000016085; -.
DR   PaxDb; Q0P5K1; -.
DR   PRIDE; Q0P5K1; -.
DR   Ensembl; ENSBTAT00000016085; ENSBTAP00000016085; ENSBTAG00000012124.
DR   GeneID; 613751; -.
DR   KEGG; bta:613751; -.
DR   CTD; 65056; -.
DR   VEuPathDB; HostDB:ENSBTAG00000012124; -.
DR   VGNC; VGNC:29522; GPBP1.
DR   eggNOG; ENOG502QR5W; Eukaryota.
DR   GeneTree; ENSGT00420000029753; -.
DR   HOGENOM; CLU_045487_0_0_1; -.
DR   InParanoid; Q0P5K1; -.
DR   OrthoDB; 662557at2759; -.
DR   TreeFam; TF332220; -.
DR   Proteomes; UP000009136; Chromosome 20.
DR   Bgee; ENSBTAG00000012124; Expressed in oocyte and 106 other tissues.
DR   ExpressionAtlas; Q0P5K1; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR028128; Vasculin_fam.
DR   PANTHER; PTHR14339; PTHR14339; 1.
DR   Pfam; PF15337; Vasculin; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Methylation; Nucleus; Phosphoprotein;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..473
FT                   /note="Vasculin"
FT                   /id="PRO_0000324109"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          44..163
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          196..240
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          258..286
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          305..342
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          444..473
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        88..115
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        116..142
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        221..240
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        305..331
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         49
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q86WP2"
FT   MOD_RES         87
FT                   /note="Omega-N-methylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:Q86WP2"
FT   MOD_RES         274
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6NXH3"
FT   MOD_RES         276
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6NXH3"
FT   MOD_RES         322
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q86WP2"
FT   MOD_RES         381
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q86WP2"
SQ   SEQUENCE   473 AA;  53420 MW;  DA7CC0105789F4BF CRC64;
     MAQHDFAPAW LNFPTPPSST KSSLNFEKHS ENFSWTENRY DVNRRRHNSS DGFDSGIGRP
     NGGNFGRKEK NGWRTHGRNG TENINHRGGY HGGSSRSRSS IFHSGKSQGL HENNIPDNET
     GRKDDKRERK QFEAEDFPSL NPEYEREPNQ NKSLAAGVWE YPPNPKSRTQ RMLVIKKGNT
     KDLQLSGFPV VGNLQSQPVK NGTGPSVYKG LVPKPAAPPT KPTQWKSQTK ENKVGTSFPH
     ESTYGVGNFN AFKSTAKNFS PSTTSVKECN RSNSSSPVDK LNQQPRLTKL TRMRTDKKSE
     FLKALKRDRV EEEHEDESHV GSEKDDDSFN LHNSNSTHQE RDINRNFDEN EIPQENGNAS
     VISQQIIRSS AFPQTDVLSS SLEAEHRLLK EMGWQEDSEN DETCAPLTED EMREFQVISE
     QLQKNGLRKN GILKNGLICD FKFGPWKNST FKPTIENDDT ETSSSDTSDD DDV