GPBP1_HUMAN
ID GPBP1_HUMAN Reviewed; 473 AA.
AC Q86WP2; A6NKW3; Q6NSH6; Q9H0D4; Q9H785; Q9NSN4;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Vasculin;
DE AltName: Full=GC-rich promoter-binding protein 1;
DE AltName: Full=Vascular wall-linked protein;
GN Name=GPBP1; Synonyms=GPBP, SSH6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING (ISOFORM 4),
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC TISSUE=Artery;
RX PubMed=12842993; DOI=10.1182/blood-2003-01-0306;
RA Bijnens A.P.J.J., Gils A., Jutten B., Faber B.C.G., Heeneman S.,
RA Kitslaar P.J.E.H.M., Tordoir J.H.M., de Vries C.J.M., Kroon A.A.,
RA Daemen M.J.A.P., Cleutjens K.B.J.M.;
RT "Vasculin, a novel vascular protein differentially expressed in human
RT atherogenesis.";
RL Blood 102:2803-2810(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and analysis of
RT 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RC TISSUE=Amygdala;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Retinoblastoma;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 164-473 (ISOFORM 1).
RC TISSUE=Smooth muscle;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [8]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=14612417; DOI=10.1128/mcb.23.23.8773-8785.2003;
RA Hsu L.-C., Liu S., Abedinpour F., Beech R.D., Lahti J.M., Kidd V.J.,
RA Greenspan J.A., Yeung C.-Y.;
RT "The murine G+C-rich promoter binding protein mGPBP is required for
RT promoter-specific transcription.";
RL Mol. Cell. Biol. 23:8773-8785(2003).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49; SER-322 AND SER-381, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [11]
RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-87, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Colon carcinoma;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
CC -!- FUNCTION: Functions as a GC-rich promoter-specific transactivating
CC transcription factor. {ECO:0000250|UniProtKB:Q6NXH3}.
CC -!- SUBUNIT: Interacts with GTF2B, GTF2F2, RNA polymerase II and TBP.
CC {ECO:0000250}.
CC -!- INTERACTION:
CC Q86WP2; Q2TAC2-2: CCDC57; NbExp=3; IntAct=EBI-2349758, EBI-10961624;
CC Q86WP2; Q3B820: FAM161A; NbExp=3; IntAct=EBI-2349758, EBI-719941;
CC Q86WP2; Q9BVV2: FNDC11; NbExp=11; IntAct=EBI-2349758, EBI-744935;
CC Q86WP2; O75031: HSF2BP; NbExp=3; IntAct=EBI-2349758, EBI-7116203;
CC Q86WP2; Q96EZ8: MCRS1; NbExp=5; IntAct=EBI-2349758, EBI-348259;
CC Q86WP2; Q15014: MORF4L2; NbExp=3; IntAct=EBI-2349758, EBI-399257;
CC Q86WP2; Q9UBU9: NXF1; NbExp=3; IntAct=EBI-2349758, EBI-398874;
CC Q86WP2; Q9H8W4: PLEKHF2; NbExp=3; IntAct=EBI-2349758, EBI-742388;
CC Q86WP2; Q99633: PRPF18; NbExp=3; IntAct=EBI-2349758, EBI-2798416;
CC Q86WP2; P20618: PSMB1; NbExp=3; IntAct=EBI-2349758, EBI-372273;
CC Q86WP2; P47897: QARS1; NbExp=3; IntAct=EBI-2349758, EBI-347462;
CC Q86WP2; P63244: RACK1; NbExp=3; IntAct=EBI-2349758, EBI-296739;
CC Q86WP2; Q5ZXN6: ankX; Xeno; NbExp=2; IntAct=EBI-2349758, EBI-26359852;
CC Q86WP2-4; Q9BVV2: FNDC11; NbExp=3; IntAct=EBI-10300058, EBI-744935;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14612417}. Cytoplasm
CC {ECO:0000269|PubMed:12842993}. Note=According to PubMed:12842993, it
CC localizes to the cytoplasm. {ECO:0000269|PubMed:12842993}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q86WP2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q86WP2-2; Sequence=VSP_032136;
CC Name=3;
CC IsoId=Q86WP2-3; Sequence=VSP_032136, VSP_032137;
CC Name=4;
CC IsoId=Q86WP2-4; Sequence=VSP_032135;
CC -!- TISSUE SPECIFICITY: Widely expressed. Some isoforms may be specifically
CC expressed in veins and arteries (at protein level). Isoform 4 is widely
CC expressed. Isoform 1, isoform 2 and isoform 3 may be specifically
CC expressed in vascular smooth muscle cells.
CC {ECO:0000269|PubMed:12842993, ECO:0000269|PubMed:14612417}.
CC -!- SIMILARITY: Belongs to the vasculin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH00267.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAH70132.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};
CC Sequence=BAB15013.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AY226828; AAO34124.1; -; mRNA.
DR EMBL; AL136844; CAB66778.1; -; mRNA.
DR EMBL; AL161991; CAB82324.2; -; mRNA.
DR EMBL; AC034244; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471123; EAW54965.1; -; Genomic_DNA.
DR EMBL; CH471123; EAW54966.1; -; Genomic_DNA.
DR EMBL; BC000267; AAH00267.1; ALT_INIT; mRNA.
DR EMBL; BC070132; AAH70132.1; ALT_SEQ; mRNA.
DR EMBL; BC113004; AAI13005.1; -; mRNA.
DR EMBL; AK024807; BAB15013.1; ALT_FRAME; mRNA.
DR CCDS; CCDS34162.1; -. [Q86WP2-1]
DR CCDS; CCDS47211.1; -. [Q86WP2-2]
DR CCDS; CCDS47212.2; -. [Q86WP2-3]
DR CCDS; CCDS56368.1; -. [Q86WP2-4]
DR PIR; T47146; T47146.
DR RefSeq; NP_001120707.2; NM_001127235.2. [Q86WP2-3]
DR RefSeq; NP_001120708.1; NM_001127236.2. [Q86WP2-2]
DR RefSeq; NP_001190175.1; NM_001203246.1. [Q86WP2-4]
DR RefSeq; NP_075064.1; NM_022913.3. [Q86WP2-1]
DR RefSeq; XP_016865245.1; XM_017009756.1.
DR RefSeq; XP_016865246.1; XM_017009757.1.
DR RefSeq; XP_016865247.1; XM_017009758.1.
DR RefSeq; XP_016865248.1; XM_017009759.1.
DR AlphaFoldDB; Q86WP2; -.
DR BioGRID; 122378; 69.
DR IntAct; Q86WP2; 40.
DR MINT; Q86WP2; -.
DR STRING; 9606.ENSP00000264779; -.
DR iPTMnet; Q86WP2; -.
DR PhosphoSitePlus; Q86WP2; -.
DR BioMuta; GPBP1; -.
DR DMDM; 74714120; -.
DR EPD; Q86WP2; -.
DR jPOST; Q86WP2; -.
DR MassIVE; Q86WP2; -.
DR MaxQB; Q86WP2; -.
DR PaxDb; Q86WP2; -.
DR PeptideAtlas; Q86WP2; -.
DR PRIDE; Q86WP2; -.
DR ProteomicsDB; 70185; -. [Q86WP2-1]
DR ProteomicsDB; 70186; -. [Q86WP2-2]
DR ProteomicsDB; 70187; -. [Q86WP2-3]
DR ProteomicsDB; 70188; -. [Q86WP2-4]
DR Antibodypedia; 11328; 89 antibodies from 22 providers.
DR DNASU; 65056; -.
DR Ensembl; ENST00000264779.6; ENSP00000264779.6; ENSG00000062194.16. [Q86WP2-2]
DR Ensembl; ENST00000506184.7; ENSP00000421202.2; ENSG00000062194.16. [Q86WP2-1]
DR Ensembl; ENST00000511209.5; ENSP00000422337.1; ENSG00000062194.16. [Q86WP2-3]
DR Ensembl; ENST00000514387.6; ENSP00000421709.2; ENSG00000062194.16. [Q86WP2-4]
DR GeneID; 65056; -.
DR KEGG; hsa:65056; -.
DR MANE-Select; ENST00000506184.7; ENSP00000421202.2; NM_022913.4; NP_075064.1.
DR UCSC; uc003jrh.5; human. [Q86WP2-1]
DR CTD; 65056; -.
DR GeneCards; GPBP1; -.
DR HGNC; HGNC:29520; GPBP1.
DR HPA; ENSG00000062194; Low tissue specificity.
DR MIM; 608412; gene.
DR neXtProt; NX_Q86WP2; -.
DR OpenTargets; ENSG00000062194; -.
DR PharmGKB; PA142671714; -.
DR VEuPathDB; HostDB:ENSG00000062194; -.
DR eggNOG; ENOG502QR5W; Eukaryota.
DR GeneTree; ENSGT00420000029753; -.
DR HOGENOM; CLU_045487_0_0_1; -.
DR InParanoid; Q86WP2; -.
DR OMA; CNFKFSP; -.
DR OrthoDB; 662557at2759; -.
DR PhylomeDB; Q86WP2; -.
DR TreeFam; TF332220; -.
DR PathwayCommons; Q86WP2; -.
DR SignaLink; Q86WP2; -.
DR BioGRID-ORCS; 65056; 23 hits in 1083 CRISPR screens.
DR ChiTaRS; GPBP1; human.
DR GeneWiki; GPBP1; -.
DR GenomeRNAi; 65056; -.
DR Pharos; Q86WP2; Tbio.
DR PRO; PR:Q86WP2; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q86WP2; protein.
DR Bgee; ENSG00000062194; Expressed in ventricular zone and 189 other tissues.
DR ExpressionAtlas; Q86WP2; baseline and differential.
DR Genevisible; Q86WP2; HS.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:Ensembl.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR028128; Vasculin_fam.
DR PANTHER; PTHR14339; PTHR14339; 1.
DR Pfam; PF15337; Vasculin; 1.
PE 1: Evidence at protein level;
KW Activator; Alternative splicing; Cytoplasm; DNA-binding; Methylation;
KW Nucleus; Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..473
FT /note="Vasculin"
FT /id="PRO_0000324110"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 46..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 191..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 444..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 116..149
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..289
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..331
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 49
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 87
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT MOD_RES 274
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6NXH3"
FT MOD_RES 276
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6NXH3"
FT MOD_RES 322
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 381
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 1..171
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_032135"
FT VAR_SEQ 20
FT /note="T -> TKVLTSSL (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:11230166,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_032136"
FT VAR_SEQ 269..283
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_032137"
FT VARIANT 122
FT /note="R -> G (in dbSNP:rs1862171)"
FT /id="VAR_039654"
FT CONFLICT 127
FT /note="R -> G (in Ref. 6; AAH70132)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 473 AA; 53339 MW; 932A7681860622C4 CRC64;
MAQHDFAPAW LNFPTPPSST KSSLNFEKHS ENFAWTENRY DVNRRRHNSS DGFDSAIGRP
NGGNFGRKEK NGWRTHGRNG TENINHRGGY HGGSSRSRSS IFHAGKSQGL HENNIPDNET
GRKEDKRERK QFEAEDFPSL NPEYEREPNH NKSLAAGVWE YPPNPKSRAP RMLVIKKGNT
KDLQLSGFPV VGNLPSQPVK NGTGPSVYKG LVPKPAAPPT KPTQWKSQTK ENKVGTSFPH
ESTFGVGNFN AFKSTAKNFS PSTNSVKECN RSNSSSPVDK LNQQPRLTKL TRMRTDKKSE
FLKALKRDRV EEEHEDESRA GSEKDDDSFN LHNSNSTHQE RDINRNFDEN EIPQENGNAS
VISQQIIRSS TFPQTDVLSS SLEAEHRLLK EMGWQEDSEN DETCAPLTED EMREFQVISE
QLQKNGLRKN GILKNGLICD FKFGPWKNST FKPTTENDDT ETSSSDTSDD DDV
