ID   GPBP1_PONAB             Reviewed;         473 AA.
AC   Q5R4E9;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Vasculin;
DE   AltName: Full=GC-rich promoter-binding protein 1;
GN   Name=GPBP1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions as a GC-rich promoter-specific transactivating
CC       transcription factor. {ECO:0000250|UniProtKB:Q6NXH3}.
CC   -!- SUBUNIT: Interacts with GTF2B, GTF2F2, RNA polymerase II and TBP.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6NXH3}.
CC   -!- SIMILARITY: Belongs to the vasculin family. {ECO:0000305}.
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DR   EMBL; CR861300; CAH93367.1; -; mRNA.
DR   RefSeq; NP_001126983.1; NM_001133511.1.
DR   AlphaFoldDB; Q5R4E9; -.
DR   GeneID; 100174003; -.
DR   KEGG; pon:100174003; -.
DR   CTD; 65056; -.
DR   eggNOG; ENOG502QR5W; Eukaryota.
DR   InParanoid; Q5R4E9; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR028128; Vasculin_fam.
DR   PANTHER; PTHR14339; PTHR14339; 1.
DR   Pfam; PF15337; Vasculin; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Methylation; Nucleus; Phosphoprotein;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..473
FT                   /note="Vasculin"
FT                   /id="PRO_0000324112"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          45..169
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          191..342
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          444..473
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        88..115
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        116..150
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        221..289
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        290..331
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         49
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q86WP2"
FT   MOD_RES         87
FT                   /note="Omega-N-methylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:Q86WP2"
FT   MOD_RES         274
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6NXH3"
FT   MOD_RES         276
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6NXH3"
FT   MOD_RES         322
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q86WP2"
FT   MOD_RES         381
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q86WP2"
SQ   SEQUENCE   473 AA;  53355 MW;  59293404F606CA41 CRC64;
     MAQHDFAPAW LNFPTPPSST KSSLNFEKHS ENFAWTENRY DVNRRRHNSS DGFDSAIGRP
     NGGNFGRKEK NGWRTHGRNG TENINHRGGY HGGSSRSRSS IFHSGKSQGL HENNIPDNET
     GRKEDKRERK QFEAEDFPSL NPEYEREPNH NKSLAAGVWE YPPNPKSRAP RMLVIKKGNT
     KDLQLSGFPV VGNLPSQPVK NGTGPSVYKG LVPKPAAPPT KPTQWKSQTK ENKVGTSFPH
     ESTFGVGNFN AFKSTAKNFS PSTNSVKECN RSNSSSPVDK LNQQPRLTKL TRMRTDKKSE
     FLKALKRDRV EEEHEDESRA GSEKDDDSFN LHNSNSTHQE RDINRNFDEN EIPQENGNAS
     VISQQIIRSS TFPQTDVLSS SLEAEHRLLK EMGWQEDSEN DETCAPITED EMREFQVISE
     QLQKNGLRKN GILKNGLICD FKFGPWKNST FKPTTENDDT ETSSSDTSDD DDV