GPC1_CHICK
ID GPC1_CHICK Reviewed; 550 AA.
AC P50593;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Glypican-1;
DE AltName: Full=Heparan sulfate proteoglycan core protein;
DE Contains:
DE RecName: Full=Secreted glypican-1;
DE Flags: Precursor;
GN Name=GPC1;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DEVELOPMENTAL STAGE.
RC TISSUE=Heart;
RX PubMed=8875073;
RX DOI=10.1002/(sici)1097-0177(199609)207:1<25::aid-aja3>3.0.co;2-y;
RA Shi N., Antin P.B., Akimoto K., Morkin E.;
RT "Expression of avian glypican is developmentally regulated.";
RL Dev. Dyn. 207:25-34(1996).
CC -!- FUNCTION: Cell surface proteoglycan that bears heparan sulfate.
CC Modulates Wnt-signaling pathway.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-
CC anchor {ECO:0000250}; Extracellular side {ECO:0000250}. Endosome
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: [Secreted glypican-1]: Secreted, extracellular
CC space {ECO:0000250}.
CC -!- DEVELOPMENTAL STAGE: Expressed at stage 7 of embryonic development in
CC the folding anterior part of the neural plate. At stage 8, high levels
CC in all four newly formed epithelial somites and in the rostra1 paraxial
CC mesoderm. Expressed also in the cephlic region of the developing neural
CC fold. Later expression in the entire limb bud, including mesenchyme and
CC ectoderm. In the developing brain, first detected at stage 7 in the
CC anterior portion of the neural folds that are destined to give rise to
CC the telencephalon. Later in development (stage 25), glypican
CC transcripts were found in postmitotic cells in the mantle zone.
CC Expressed by ectodermal and ingressing chick trigeminal placode cells
CC at the time they differentiate into neurons and assemble into ganglia.
CC Also expressed in the migrating hindbrain neural crest cells from
CC rhombomeres 4 and 6 during migration at stage 12.
CC {ECO:0000269|PubMed:8875073}.
CC -!- PTM: O-glycosylated with heparan sulfate. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the glypican family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA65199.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; L29089; AAA65199.1; ALT_INIT; Genomic_DNA.
DR AlphaFoldDB; P50593; -.
DR SMR; P50593; -.
DR STRING; 9031.ENSGALP00000003684; -.
DR PaxDb; P50593; -.
DR VEuPathDB; HostDB:geneid_424770; -.
DR eggNOG; KOG3821; Eukaryota.
DR InParanoid; P50593; -.
DR PhylomeDB; P50593; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0046658; C:anchored component of plasma membrane; IEA:InterPro.
DR GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:InterPro.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0017134; F:fibroblast growth factor binding; IBA:GO_Central.
DR GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR GO; GO:0040037; P:negative regulation of fibroblast growth factor receptor signaling pathway; IBA:GO_Central.
DR GO; GO:1902725; P:negative regulation of satellite cell differentiation; ISS:AgBase.
DR GO; GO:1902723; P:negative regulation of skeletal muscle satellite cell proliferation; ISS:AgBase.
DR GO; GO:1902726; P:positive regulation of skeletal muscle satellite cell differentiation; ISS:AgBase.
DR GO; GO:1902724; P:positive regulation of skeletal muscle satellite cell proliferation; ISS:AgBase.
DR GO; GO:1905475; P:regulation of protein localization to membrane; IBA:GO_Central.
DR InterPro; IPR001863; Glypican.
DR InterPro; IPR015502; Glypican-1.
DR InterPro; IPR019803; Glypican_CS.
DR PANTHER; PTHR10822; PTHR10822; 1.
DR PANTHER; PTHR10822:SF8; PTHR10822:SF8; 1.
DR Pfam; PF01153; Glypican; 1.
DR PROSITE; PS01207; GLYPICAN; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Endosome; Glycoprotein; GPI-anchor;
KW Heparan sulfate; Lipoprotein; Membrane; Proteoglycan; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..524
FT /note="Glypican-1"
FT /id="PRO_0000012301"
FT CHAIN 21..?
FT /note="Secreted glypican-1"
FT /id="PRO_0000333840"
FT PROPEP 525..550
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000012302"
FT REGION 475..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 502..522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 524
FT /note="GPI-anchor amidated glycine"
FT /evidence="ECO:0000255"
FT CARBOHYD 76
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 113
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 382
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 483
FT /note="O-linked (Xyl...) (heparan sulfate) serine"
FT /evidence="ECO:0000255"
FT CARBOHYD 485
FT /note="O-linked (Xyl...) (heparan sulfate) serine"
FT /evidence="ECO:0000255"
FT CARBOHYD 487
FT /note="O-linked (Xyl...) (heparan sulfate) serine"
FT /evidence="ECO:0000255"
FT DISULFID 29..65
FT /evidence="ECO:0000250"
FT DISULFID 59..253
FT /evidence="ECO:0000250"
FT DISULFID 66..256
FT /evidence="ECO:0000250"
FT DISULFID 188..340
FT /evidence="ECO:0000250"
FT DISULFID 243..276
FT /evidence="ECO:0000250"
FT DISULFID 265..412
FT /evidence="ECO:0000250"
FT DISULFID 269..398
FT /evidence="ECO:0000250"
SQ SEQUENCE 550 AA; 61084 MW; 6B7B796E506BF7FF CRC64;
MRFFPWGFWL LCVASAPARG DSGSKARSCA EVRQLYGAKG FSLNGVPQAE ISGEHLRICP
QGYTCCTSEM EENFANKSRS EFEAMMKEAG RSVQTILTAQ YKSFDNYFQD LLNKSEKALY
DTFPSLYGDL YTQNMKVFKD LYSELRRYYR GSNINLEEAL NEFWTRLLER LFKLMNAQYH
ITDEYLDCMV KHAEQHKPFG EVPRDLKVKA TRAFIVARSY AQGFLVGSDV VKKVSQVSLS
HECTRAVMKL MYCPHCRGMA SVKPCSNYCL NVVKGCLANQ ADLNTEWKYL MDALVAVADR
IDGPYNVDTV IGTIHMRISE AISNLQENKV SITAKVFQGC GNPKVSMKGS SSEDKKRRGK
VTLEAKSSAV ALEMLVLDAK GNLTALKSYW VTLPGVLCSK KIMASPAEDD KCWNGMTKGS
YLPEVMGGGL ANQINNPEVE VDITKPDMTI RQQIMQLKIM TNRLGNANIG NDVDFQDASD
DMSGSGSGDS CPDDVCVKRL SKSPSTRQPE THAIPKQSGH GVIGASSRSL PSAFLLFLSG
ASIVVQHLWR
