GPC5C_MOUSE
ID GPC5C_MOUSE Reviewed; 440 AA.
AC Q8K3J9; Q8K0H0;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 13-APR-2004, sequence version 2.
DT 25-MAY-2022, entry version 128.
DE RecName: Full=G-protein coupled receptor family C group 5 member C;
DE AltName: Full=Retinoic acid-induced gene 3 protein;
DE Short=RAIG-3;
DE Flags: Precursor;
GN Name=Gprc5c; Synonyms=Raig3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ; TISSUE=Kidney;
RA Tao Q., Lotan R.;
RT "Molecular cloning and characterization of mouse retinoic acid-inducible
RT orphan G protein-coupled receptors.";
RL Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-402; SER-405; TYR-413 AND
RP THR-422, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: This retinoic acid-inducible G-protein coupled receptor
CC provide evidence for a possible interaction between retinoid and G-
CC protein signaling pathways. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000305}.
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DR EMBL; AY079516; AAL87525.1; -; mRNA.
DR EMBL; BC031439; AAH31439.1; -; mRNA.
DR CCDS; CCDS25612.1; -.
DR RefSeq; NP_001103808.1; NM_001110338.1.
DR RefSeq; NP_671750.2; NM_147217.3.
DR RefSeq; XP_006534228.1; XM_006534165.1.
DR AlphaFoldDB; Q8K3J9; -.
DR STRING; 10090.ENSMUSP00000061760; -.
DR GlyGen; Q8K3J9; 1 site.
DR iPTMnet; Q8K3J9; -.
DR PhosphoSitePlus; Q8K3J9; -.
DR jPOST; Q8K3J9; -.
DR MaxQB; Q8K3J9; -.
DR PaxDb; Q8K3J9; -.
DR PRIDE; Q8K3J9; -.
DR ProteomicsDB; 271034; -.
DR DNASU; 70355; -.
DR GeneID; 70355; -.
DR KEGG; mmu:70355; -.
DR CTD; 55890; -.
DR MGI; MGI:1917605; Gprc5c.
DR eggNOG; ENOG502QQEH; Eukaryota.
DR InParanoid; Q8K3J9; -.
DR BioGRID-ORCS; 70355; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Gprc5c; mouse.
DR PRO; PR:Q8K3J9; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q8K3J9; protein.
DR GO; GO:0070062; C:extracellular exosome; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0043235; C:receptor complex; ISO:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0030295; F:protein kinase activator activity; IBA:GO_Central.
DR GO; GO:0005118; F:sevenless binding; IEA:InterPro.
DR GO; GO:0007601; P:visual perception; IEA:InterPro.
DR InterPro; IPR002956; Bride_of_7less.
DR InterPro; IPR017978; GPCR_3_C.
DR Pfam; PF00003; 7tm_3; 1.
DR PRINTS; PR01223; BRIDEOF7LESS.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 1: Evidence at protein level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Phosphoprotein; Receptor; Reference proteome; Signal; Transducer;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..440
FT /note="G-protein coupled receptor family C group 5 member
FT C"
FT /id="PRO_0000012968"
FT TOPO_DOM 23..49
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..70
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 71..84
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..105
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 106..119
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..140
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 141..155
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..176
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 177..207
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 208..228
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 229..240
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 262..278
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 279..299
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 300..440
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOD_RES 343
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NQ84"
FT MOD_RES 382
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NQ84"
FT MOD_RES 402
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 405
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 413
FT /note="Phosphotyrosine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 422
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CARBOHYD 190
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 52
FT /note="S -> L (in Ref. 1; AAL87525)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 440 AA; 48422 MW; BA0B13B7631017B4 CRC64;
MATHRTLLMC LGLPLFFPGA LAQNHAPPGC SPDLDPLYYN LCDRSGAWGI VSEAVAGAGI
ITTFVLTIIL VASLPFVQDT KKRSLLGTQV FFLLGTLGLF CLVFACVVKP DFSTCASRRF
LFGVLFAICF SCLVAHVLSL NFLTRKNHGP RGWVIFTVAL LLTLVEVIIN TEWLIITLVR
GGGQVSPLGN VSADSTMTSP CAIANMDFVM ALIYVMLLLL TAFLGAWPTL CGRFKRWRKH
GVFVLLTTVI SIAIWVVWIV MYTYGNEQHH SPTWDDPTLA IALAANAWTF VLFYVIPEVS
QVTKPSPEQS YQGDMYPTRG VGYETILKEQ TGQSMFVENK AFSMDEPASA KRPVSPYSGY
NGQLLTSVYQ PTEMALMHKG PSEGAYDVIL PRATANSQVM GSANSTLRAE DMYMVQSHQV
ATPPKDGKIS QVFRNPYVWD
