GPC5D_HUMAN
ID GPC5D_HUMAN Reviewed; 345 AA.
AC Q9NZD1; Q3KNV3; Q7Z5J9; Q8TDS6;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=G-protein coupled receptor family C group 5 member D;
GN Name=GPRC5D;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, SUBCELLULAR
RP LOCATION, AND INDUCTION.
RC TISSUE=Testis;
RX PubMed=11311935; DOI=10.1016/s0167-4781(01)00197-x;
RA Braeuner-Osborne H., Jensen A.A., Sheppard P.O., Brodin B.,
RA Krogsgaard-Larsen P., O'Hara P.;
RT "Cloning and characterization of a human orphan family C G-protein coupled
RT receptor GPRC5D.";
RL Biochim. Biophys. Acta 1518:237-248(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC TISSUE=Skin;
RA Inoue S., Nanbu T., Shimomura T.;
RT "Characterization of GPRC5D, a member of RAIG family in hard keratinized
RT structures.";
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 3).
RX PubMed=12044878; DOI=10.1016/s0014-5793(02)02775-8;
RA Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.;
RT "Identification of G protein-coupled receptor genes from the human genome
RT sequence.";
RL FEBS Lett. 520:97-101(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q9NZD1; O95236-2: APOL3; NbExp=3; IntAct=EBI-13067820, EBI-11976321;
CC Q9NZD1; Q8WVV5: BTN2A2; NbExp=3; IntAct=EBI-13067820, EBI-8648738;
CC Q9NZD1; P13236: CCL4; NbExp=3; IntAct=EBI-13067820, EBI-2873970;
CC Q9NZD1; P54849: EMP1; NbExp=3; IntAct=EBI-13067820, EBI-4319440;
CC Q9NZD1; Q7Z2K6: ERMP1; NbExp=3; IntAct=EBI-13067820, EBI-10976398;
CC Q9NZD1; Q14802-3: FXYD3; NbExp=3; IntAct=EBI-13067820, EBI-12175685;
CC Q9NZD1; P02724: GYPA; NbExp=3; IntAct=EBI-13067820, EBI-702665;
CC Q9NZD1; Q01628: IFITM3; NbExp=3; IntAct=EBI-13067820, EBI-7932862;
CC Q9NZD1; P24593: IGFBP5; NbExp=3; IntAct=EBI-13067820, EBI-720480;
CC Q9NZD1; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-13067820, EBI-2820517;
CC Q9NZD1; Q8N386: LRRC25; NbExp=3; IntAct=EBI-13067820, EBI-11304917;
CC Q9NZD1; Q9H2W1: MS4A6A; NbExp=3; IntAct=EBI-13067820, EBI-1266965;
CC Q9NZD1; Q8N912: NRAC; NbExp=3; IntAct=EBI-13067820, EBI-12051377;
CC Q9NZD1; Q99650: OSMR; NbExp=3; IntAct=EBI-13067820, EBI-2804080;
CC Q9NZD1; Q01453: PMP22; NbExp=3; IntAct=EBI-13067820, EBI-2845982;
CC Q9NZD1; Q7Z6L0: PRRT2; NbExp=3; IntAct=EBI-13067820, EBI-722696;
CC Q9NZD1; P15151: PVR; NbExp=3; IntAct=EBI-13067820, EBI-3919694;
CC Q9NZD1; Q9BRI3: SLC30A2; NbExp=3; IntAct=EBI-13067820, EBI-8644112;
CC Q9NZD1; Q6ZP29-3: SLC66A1; NbExp=3; IntAct=EBI-13067820, EBI-12889586;
CC Q9NZD1; Q9H7V2: SYNDIG1; NbExp=3; IntAct=EBI-13067820, EBI-726331;
CC Q9NZD1; A0PK00: TMEM120B; NbExp=3; IntAct=EBI-13067820, EBI-10171534;
CC Q9NZD1; Q96HH6: TMEM19; NbExp=3; IntAct=EBI-13067820, EBI-741829;
CC Q9NZD1; Q9BTX3: TMEM208; NbExp=3; IntAct=EBI-13067820, EBI-12876824;
CC Q9NZD1; Q9BSE2: TMEM79; NbExp=3; IntAct=EBI-13067820, EBI-8649725;
CC Q9NZD1; A5PKU2: TUSC5; NbExp=3; IntAct=EBI-13067820, EBI-11988865;
CC Q9NZD1; Q9GZX9: TWSG1; NbExp=3; IntAct=EBI-13067820, EBI-10304067;
CC Q9NZD1; Q9H1C4: UNC93B1; NbExp=3; IntAct=EBI-13067820, EBI-4401271;
CC Q9NZD1; Q9Y548: YIPF1; NbExp=3; IntAct=EBI-13067820, EBI-7850136;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11311935};
CC Multi-pass membrane protein {ECO:0000269|PubMed:11311935}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9NZD1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NZD1-2; Sequence=VSP_010006, VSP_010007;
CC Name=3;
CC IsoId=Q9NZD1-3; Sequence=VSP_010008;
CC -!- TISSUE SPECIFICITY: Widely expressed in the peripheral system.
CC Expression pattern is high in pancreas, medium in kidney, small
CC intestine, spleen and testis, low in lung, colon, leukocyte, prostate
CC and thymus and not detectable in brain, heart, liver, placenta,
CC skeletal muscle and ovary. {ECO:0000269|PubMed:11311935}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000305}.
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DR EMBL; AF209923; AAF72873.1; -; mRNA.
DR EMBL; AB099817; BAC79169.1; -; mRNA.
DR EMBL; AB083629; BAB89342.1; -; Genomic_DNA.
DR EMBL; BC069341; AAH69341.1; -; mRNA.
DR EMBL; BC107077; AAI07078.1; -; mRNA.
DR EMBL; BC107078; AAI07079.1; -; mRNA.
DR CCDS; CCDS8658.1; -. [Q9NZD1-1]
DR RefSeq; NP_061124.1; NM_018654.1. [Q9NZD1-1]
DR RefSeq; XP_005253478.1; XM_005253421.3. [Q9NZD1-1]
DR RefSeq; XP_016875071.1; XM_017019582.1. [Q9NZD1-1]
DR RefSeq; XP_016875072.1; XM_017019583.1. [Q9NZD1-2]
DR AlphaFoldDB; Q9NZD1; -.
DR SMR; Q9NZD1; -.
DR BioGRID; 120687; 73.
DR IntAct; Q9NZD1; 28.
DR STRING; 9606.ENSP00000228887; -.
DR ChEMBL; CHEMBL4523925; -.
DR iPTMnet; Q9NZD1; -.
DR PhosphoSitePlus; Q9NZD1; -.
DR BioMuta; GPRC5D; -.
DR DMDM; 46396015; -.
DR MassIVE; Q9NZD1; -.
DR PaxDb; Q9NZD1; -.
DR PeptideAtlas; Q9NZD1; -.
DR PRIDE; Q9NZD1; -.
DR ProteomicsDB; 83372; -. [Q9NZD1-1]
DR ProteomicsDB; 83373; -. [Q9NZD1-2]
DR ProteomicsDB; 83374; -. [Q9NZD1-3]
DR ABCD; Q9NZD1; 32 sequenced antibodies.
DR Antibodypedia; 11949; 223 antibodies from 28 providers.
DR DNASU; 55507; -.
DR Ensembl; ENST00000228887.5; ENSP00000228887.1; ENSG00000111291.8. [Q9NZD1-1]
DR Ensembl; ENST00000396333.3; ENSP00000379624.3; ENSG00000111291.8. [Q9NZD1-2]
DR GeneID; 55507; -.
DR KEGG; hsa:55507; -.
DR MANE-Select; ENST00000228887.6; ENSP00000228887.1; NM_018654.2; NP_061124.1.
DR UCSC; uc010shp.2; human. [Q9NZD1-1]
DR CTD; 55507; -.
DR DisGeNET; 55507; -.
DR GeneCards; GPRC5D; -.
DR HGNC; HGNC:13310; GPRC5D.
DR HPA; ENSG00000111291; Tissue enriched (skin).
DR MIM; 607437; gene.
DR neXtProt; NX_Q9NZD1; -.
DR OpenTargets; ENSG00000111291; -.
DR PharmGKB; PA28940; -.
DR VEuPathDB; HostDB:ENSG00000111291; -.
DR eggNOG; ENOG502SKRS; Eukaryota.
DR GeneTree; ENSGT00950000182961; -.
DR HOGENOM; CLU_044162_0_1_1; -.
DR InParanoid; Q9NZD1; -.
DR OMA; RSCKQDC; -.
DR OrthoDB; 807909at2759; -.
DR PhylomeDB; Q9NZD1; -.
DR TreeFam; TF321410; -.
DR PathwayCommons; Q9NZD1; -.
DR SignaLink; Q9NZD1; -.
DR BioGRID-ORCS; 55507; 10 hits in 1065 CRISPR screens.
DR GeneWiki; GPRC5D; -.
DR GenomeRNAi; 55507; -.
DR Pharos; Q9NZD1; Tbio.
DR PRO; PR:Q9NZD1; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q9NZD1; protein.
DR Bgee; ENSG00000111291; Expressed in upper lobe of left lung and 97 other tissues.
DR ExpressionAtlas; Q9NZD1; baseline and differential.
DR Genevisible; Q9NZD1; HS.
DR GO; GO:0070062; C:extracellular exosome; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0030295; F:protein kinase activator activity; IBA:GO_Central.
DR InterPro; IPR017978; GPCR_3_C.
DR Pfam; PF00003; 7tm_3; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; G-protein coupled receptor; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..345
FT /note="G-protein coupled receptor family C group 5 member
FT D"
FT /id="PRO_0000206897"
FT TOPO_DOM 1..27
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..63
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 64..84
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 85..93
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 115..123
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 145..167
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..188
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 189..204
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 226..239
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..345
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT VAR_SEQ 299..345
FT /note="ARDSDGAEEDVALTSYGTPIQPQTVDPTQECFIPQAKLSPQQDAGGV -> G
FT TFLGDSGSREVLLQEKQEKNHAVG (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_010008"
FT VAR_SEQ 299..300
FT /note="AR -> DC (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_010006"
FT VAR_SEQ 301..345
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_010007"
FT VARIANT 18
FT /note="A -> D (in dbSNP:rs3741822)"
FT /id="VAR_018297"
SQ SEQUENCE 345 AA; 38791 MW; 14B09E4C5E9F9B49 CRC64;
MYKDCIESTG DYFLLCDAEG PWGIILESLA ILGIVVTILL LLAFLFLMRK IQDCSQWNVL
PTQLLFLLSV LGLFGLAFAF IIELNQQTAP VRYFLFGVLF ALCFSCLLAH ASNLVKLVRG
CVSFSWTTIL CIAIGCSLLQ IIIATEYVTL IMTRGMMFVN MTPCQLNVDF VVLLVYVLFL
MALTFFVSKA TFCGPCENWK QHGRLIFITV LFSIIIWVVW ISMLLRGNPQ FQRQPQWDDP
VVCIALVTNA WVFLLLYIVP ELCILYRSCR QECPLQGNAC PVTAYQHSFQ VENQELSRAR
DSDGAEEDVA LTSYGTPIQP QTVDPTQECF IPQAKLSPQQ DAGGV
