GPC5D_MOUSE
ID GPC5D_MOUSE Reviewed; 344 AA.
AC Q9JIL6; Q8CJI0; Q8CJI1;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 13-APR-2004, sequence version 2.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=G-protein coupled receptor family C group 5 member D;
GN Name=Gprc5d;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RX PubMed=11311935; DOI=10.1016/s0167-4781(01)00197-x;
RA Braeuner-Osborne H., Jensen A.A., Sheppard P.O., Brodin B.,
RA Krogsgaard-Larsen P., O'Hara P.;
RT "Cloning and characterization of a human orphan family C G-protein coupled
RT receptor GPRC5D.";
RL Biochim. Biophys. Acta 1518:237-248(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC TISSUE=Skin;
RA Inoue S., Nanbu T., Shimomura T.;
RT "Characterization of GPRC5D, a member of RAIG family in hard keratinized
RT structures.";
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 3-344 (ISOFORMS 1 AND 2).
RC TISSUE=Skin;
RA Ishibashi K.;
RT "Molecular cloning of new putative G protein-coupled receptors from skin.";
RL Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9JIL6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9JIL6-2; Sequence=VSP_010009, VSP_010010;
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC20266.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAC20267.1; Type=Frameshift; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF218809; AAF72880.1; -; mRNA.
DR EMBL; AB099816; BAC79168.1; -; mRNA.
DR EMBL; AB025221; BAC20266.1; ALT_FRAME; mRNA.
DR EMBL; AB025222; BAC20267.1; ALT_FRAME; mRNA.
DR CCDS; CCDS39680.1; -. [Q9JIL6-2]
DR CCDS; CCDS57462.1; -. [Q9JIL6-1]
DR RefSeq; NP_001192325.1; NM_001205396.1. [Q9JIL6-1]
DR RefSeq; NP_444348.1; NM_053118.1. [Q9JIL6-2]
DR AlphaFoldDB; Q9JIL6; -.
DR SMR; Q9JIL6; -.
DR STRING; 10090.ENSMUSP00000107553; -.
DR PhosphoSitePlus; Q9JIL6; -.
DR PaxDb; Q9JIL6; -.
DR PRIDE; Q9JIL6; -.
DR ProteomicsDB; 271316; -. [Q9JIL6-1]
DR ProteomicsDB; 271317; -. [Q9JIL6-2]
DR Antibodypedia; 11949; 223 antibodies from 28 providers.
DR DNASU; 93746; -.
DR Ensembl; ENSMUST00000032327; ENSMUSP00000032327; ENSMUSG00000030205. [Q9JIL6-1]
DR Ensembl; ENSMUST00000111922; ENSMUSP00000107553; ENSMUSG00000030205. [Q9JIL6-2]
DR GeneID; 93746; -.
DR KEGG; mmu:93746; -.
DR UCSC; uc009elg.1; mouse. [Q9JIL6-1]
DR CTD; 55507; -.
DR MGI; MGI:1935037; Gprc5d.
DR VEuPathDB; HostDB:ENSMUSG00000030205; -.
DR eggNOG; ENOG502SKRS; Eukaryota.
DR GeneTree; ENSGT00950000182961; -.
DR HOGENOM; CLU_044162_0_1_1; -.
DR InParanoid; Q9JIL6; -.
DR OMA; RSCKQDC; -.
DR PhylomeDB; Q9JIL6; -.
DR TreeFam; TF321410; -.
DR BioGRID-ORCS; 93746; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q9JIL6; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q9JIL6; protein.
DR Bgee; ENSMUSG00000030205; Expressed in lip and 9 other tissues.
DR ExpressionAtlas; Q9JIL6; baseline and differential.
DR Genevisible; Q9JIL6; MM.
DR GO; GO:0070062; C:extracellular exosome; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:MGI.
DR GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0030295; F:protein kinase activator activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0042633; P:hair cycle; NAS:UniProtKB.
DR GO; GO:0031424; P:keratinization; NAS:UniProtKB.
DR InterPro; IPR017978; GPCR_3_C.
DR Pfam; PF00003; 7tm_3; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; G-protein coupled receptor; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..344
FT /note="G-protein coupled receptor family C group 5 member
FT D"
FT /id="PRO_0000206898"
FT TOPO_DOM 1..27
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..63
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 64..84
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 85..93
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 115..124
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..145
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 146..167
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..188
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 189..204
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 226..239
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..344
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT VAR_SEQ 299..300
FT /note="AR -> EC (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11311935, ECO:0000303|Ref.2,
FT ECO:0000303|Ref.3"
FT /id="VSP_010009"
FT VAR_SEQ 301..344
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11311935, ECO:0000303|Ref.2,
FT ECO:0000303|Ref.3"
FT /id="VSP_010010"
FT CONFLICT 24
FT /note="I -> C (in Ref. 3)"
FT /evidence="ECO:0000305"
FT CONFLICT 234..235
FT /note="QP -> HA (in Ref. 3; BAC20266/BAC20267)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 344 AA; 39056 MW; CBBC1B6A3F683764 CRC64;
MYEDCVKSTE DYYLFCDNEG PWAIVLESLA VIGIVVTILL LLAFLFLMRK VQDCSQWNVL
PTQFLFLLAV LGLFGLTFAF IIQLNHQTAP VRYFLFGVLF AICFSCLLAH ASNLVKLVRG
RVSFCWTTIL FIAIGVSLLQ TIIAIEYVTL IMTRGLMFEH MTPYQLNVDF VCLLIYVLFL
MALTFFVSKA TFCGPCENWK QHGRLIFATV LVSIIIWVVW ISMLLRGNPQ LQRQPHWDDA
VICIGLVTNA WVFLLIYIIP ELSILYRSCR QECPTQGNVC QVPVYQRSFR MDTQEPTRAR
DSDGAQEDVA LTAYGTPIQL QSADPSREYL IPSATLSPQQ DAGL
