ID   GPC6_PONAB              Reviewed;         555 AA.
AC   Q5RE54;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Glypican-6;
DE   Contains:
DE     RecName: Full=Secreted glypican-6;
DE   Flags: Precursor;
GN   Name=GPC6;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cell surface proteoglycan that bears heparan sulfate.
CC       Putative cell surface coreceptor for growth factors, extracellular
CC       matrix proteins, proteases and anti-proteases. Enhances migration and
CC       invasion of cancer cells through WNT5A signaling (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-
CC       anchor {ECO:0000250}; Extracellular side {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: [Secreted glypican-6]: Secreted, extracellular
CC       space {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the glypican family. {ECO:0000305}.
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DR   EMBL; CR857683; CAH89953.1; -; mRNA.
DR   RefSeq; NP_001124916.1; NM_001131444.1.
DR   AlphaFoldDB; Q5RE54; -.
DR   SMR; Q5RE54; -.
DR   STRING; 9601.ENSPPYP00000006200; -.
DR   Ensembl; ENSPPYT00000006445; ENSPPYP00000006200; ENSPPYG00000005442.
DR   GeneID; 100171786; -.
DR   KEGG; pon:100171786; -.
DR   CTD; 10082; -.
DR   eggNOG; KOG3821; Eukaryota.
DR   GeneTree; ENSGT01050000244897; -.
DR   HOGENOM; CLU_024658_2_0_1; -.
DR   InParanoid; Q5RE54; -.
DR   OMA; RSGPMED; -.
DR   OrthoDB; 611422at2759; -.
DR   TreeFam; TF105317; -.
DR   Proteomes; UP000001595; Chromosome 13.
DR   GO; GO:0046658; C:anchored component of plasma membrane; IEA:InterPro.
DR   GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:InterPro.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR   GO; GO:0043202; C:lysosomal lumen; IEA:UniProt.
DR   GO; GO:0016477; P:cell migration; ISS:UniProtKB.
DR   GO; GO:0009966; P:regulation of signal transduction; IEA:InterPro.
DR   InterPro; IPR001863; Glypican.
DR   InterPro; IPR031183; Glypican-6.
DR   InterPro; IPR019803; Glypican_CS.
DR   PANTHER; PTHR10822; PTHR10822; 1.
DR   PANTHER; PTHR10822:SF31; PTHR10822:SF31; 1.
DR   Pfam; PF01153; Glypican; 1.
DR   PROSITE; PS01207; GLYPICAN; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; GPI-anchor; Heparan sulfate; Lipoprotein;
KW   Membrane; Proteoglycan; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..529
FT                   /note="Glypican-6"
FT                   /id="PRO_0000373796"
FT   CHAIN           24..?
FT                   /note="Secreted glypican-6"
FT                   /id="PRO_0000373797"
FT   PROPEP          530..555
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000373798"
FT   REGION          348..376
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           529
FT                   /note="GPI-anchor amidated serine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   555 AA;  62766 MW;  CE99813640CB6923 CRC64;
     MPSWIGAVIL PLLGLLLSLP AGADVKARSC GEVRQAYGAK GFSLADIPYQ EIAGEHLRIC
     PQEYTCCTTE MEDKLSQQSK LEFENLVEET SHFVRTTFVS RHKKFDEFFR ELLENAEKSL
     NDMFVRTYGM LYMQNSEVFQ DLFTELKRYY TGGNVNLEEM LNDFWARLLE RMFQLINPQY
     HFSEDYLECV SKYTDQLKPF GDVPRKLKIQ VTRAFIAART FVQGLTVGRE VANRVSKVSP
     TPGCIRALMK MLYCPYCRGL PTVRPCNNYC LNVMKGCLAN QADLDTEWNL FIDAMLLVAE
     RLEGPFNIES VMDPIDVKIS EAIMNMQENS MQVSAKVFQG CGQPKPAPAL RSARSAPENF
     NTRFRPYNPE ERPTTAAGTS LDRLVTDIKE KLKLSKKVWS SLPYTICKDE SMTAGTSNEE
     ECWNGHSKAR YLPEIMNDGL TNQINNPEVD VDITRPDTFI RQQIMALRVM TNKLKNAYNG
     NDVNFQDTSD ESSGSGSGSG CIDDVCPTEF EFVTTEAPAV DPDRREVDSS AAQRGHSLLS
     WSLTCIVLAL QRLCR