GPCP1_CAEEL
ID GPCP1_CAEEL Reviewed; 690 AA.
AC Q21407; G4S033; H2KYS5; H2KYS6;
DT 23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 13-JUN-2012, sequence version 2.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Putative glycerophosphocholine phosphodiesterase GPCPD1 homolog 1 {ECO:0000250|UniProtKB:Q8C0L9};
DE EC=3.1.-.-;
GN Name=gpcp-1 {ECO:0000312|WormBase:K10B3.6d};
GN ORFNames=K10B3.6 {ECO:0000312|WormBase:K10B3.6d};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=d;
CC IsoId=Q21407-1; Sequence=Displayed;
CC Name=a;
CC IsoId=Q21407-2; Sequence=VSP_043935;
CC Name=b;
CC IsoId=Q21407-3; Sequence=VSP_043935, VSP_043938, VSP_043939,
CC VSP_043940;
CC Name=c;
CC IsoId=Q21407-4; Sequence=VSP_043936, VSP_043937;
CC -!- SIMILARITY: Belongs to the glycerophosphoryl diester phosphodiesterase
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FO080552; CCD64603.1; -; Genomic_DNA.
DR EMBL; FO080552; CCD64604.1; -; Genomic_DNA.
DR EMBL; FO080552; CCD64605.1; -; Genomic_DNA.
DR EMBL; FO080552; CCD64606.1; -; Genomic_DNA.
DR PIR; T16609; T16609.
DR RefSeq; NP_001024784.2; NM_001029613.2. [Q21407-2]
DR RefSeq; NP_001024785.2; NM_001029614.3.
DR RefSeq; NP_001024786.2; NM_001029615.2.
DR RefSeq; NP_001256998.1; NM_001270069.1. [Q21407-1]
DR AlphaFoldDB; Q21407; -.
DR SMR; Q21407; -.
DR STRING; 6239.K10B3.6d.2; -.
DR EPD; Q21407; -.
DR PaxDb; Q21407; -.
DR PeptideAtlas; Q21407; -.
DR EnsemblMetazoa; K10B3.6a.1; K10B3.6a.1; WBGene00019612. [Q21407-2]
DR EnsemblMetazoa; K10B3.6b.1; K10B3.6b.1; WBGene00019612. [Q21407-3]
DR EnsemblMetazoa; K10B3.6d.1; K10B3.6d.1; WBGene00019612. [Q21407-1]
DR GeneID; 180600; -.
DR KEGG; cel:CELE_K10B3.6; -.
DR UCSC; K10B3.6a; c. elegans. [Q21407-1]
DR CTD; 180600; -.
DR WormBase; K10B3.6a; CE46326; WBGene00019612; gpcp-1. [Q21407-2]
DR WormBase; K10B3.6b; CE46407; WBGene00019612; gpcp-1. [Q21407-3]
DR WormBase; K10B3.6c; CE46481; WBGene00019612; gpcp-1. [Q21407-4]
DR WormBase; K10B3.6d; CE46163; WBGene00019612; gpcp-1. [Q21407-1]
DR eggNOG; KOG2421; Eukaryota.
DR InParanoid; Q21407; -.
DR OMA; DICTMIT; -.
DR OrthoDB; 1203055at2759; -.
DR PhylomeDB; Q21407; -.
DR PRO; PR:Q21407; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00019612; Expressed in larva and 3 other tissues.
DR GO; GO:0047389; F:glycerophosphocholine phosphodiesterase activity; IBA:GO_Central.
DR GO; GO:2001070; F:starch binding; IEA:InterPro.
DR GO; GO:0046475; P:glycerophospholipid catabolic process; IBA:GO_Central.
DR CDD; cd05814; CBM20_Prei4; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR Gene3D; 3.20.20.190; -; 1.
DR InterPro; IPR013784; Carb-bd-like_fold.
DR InterPro; IPR034839; CBM20_GPCPD1.
DR InterPro; IPR002044; CBM_fam20.
DR InterPro; IPR030395; GP_PDE_dom.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR Pfam; PF00686; CBM_20; 1.
DR Pfam; PF03009; GDPD; 1.
DR SMART; SM01065; CBM_2; 1.
DR SUPFAM; SSF49452; SSF49452; 1.
DR SUPFAM; SSF51695; SSF51695; 1.
DR PROSITE; PS51166; CBM20; 1.
DR PROSITE; PS51704; GP_PDE; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Hydrolase; Reference proteome.
FT CHAIN 1..690
FT /note="Putative glycerophosphocholine phosphodiesterase
FT GPCPD1 homolog 1"
FT /evidence="ECO:0000305"
FT /id="PRO_0000417919"
FT DOMAIN 1..122
FT /note="CBM20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00594"
FT DOMAIN 344..654
FT /note="GP-PDE"
FT REGION 670..690
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 177..202
FT /note="Missing (in isoform a and isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_043935"
FT VAR_SEQ 177..178
FT /note="MF -> VS (in isoform c)"
FT /evidence="ECO:0000305"
FT /id="VSP_043936"
FT VAR_SEQ 179..690
FT /note="Missing (in isoform c)"
FT /evidence="ECO:0000305"
FT /id="VSP_043937"
FT VAR_SEQ 359..432
FT /note="NIGQRENTIFSLNEAARRGADYVEMDVQLTKDLKTVVYHDFHVLVAVAGRDS
FT PSSTPTAAGENKSLHEIAIKDL -> FVESAGDPFLNLNSE (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_043938"
FT VAR_SEQ 436..443
FT /note="QLNLLHFE -> KERTLYFP (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_043939"
FT VAR_SEQ 444..690
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_043940"
SQ SEQUENCE 690 AA; 78735 MW; F6D0E1100EE399D4 CRC64;
MDQDYKAHFK VFCSEVREWE KIHVVGSLPV LGEWNPRKSF PLTKSTDEEN TFHAIVSVPS
SIKEFNFRYI RVMYLDPSEN NTSEPIMVLS KWETFNNART CLIGVESQDG VARKNITDQF
GSYSGKTQIT DGWILNEKES VVYFRIHGEA LKFFAKSYAN KEYRLKVEPF DVRYSEMFSY
TRKDITDRRG VWRHSSVYAS MSIDGDDVVN LPTPSLPCFS NTDLSVLTRE DPIFGDQYFN
GSVFRNDQDY LVFRTRTVSL QNLAFRIEFY HGEKRCALSY VLPSSMSGTH GATVSPVIGL
SSAPVGHINV NYMIVKRNKY TDQNLDIDSM KTTFGRYWRK RNRMLQIGHR GMGSSYTKNI
GQRENTIFSL NEAARRGADY VEMDVQLTKD LKTVVYHDFH VLVAVAGRDS PSSTPTAAGE
NKSLHEIAIK DLTLAQLNLL HFEHISRANG SSAESPVALS VTPSKTETDE LHVPFPSLAQ
VLRHVDENVG LNIEIKYPMY MQDGSHECQG YFEQNKFVDI ILAEVAEHAG NRRIIFSCFE
PDICTMITKK QHKYPVSFLV VGATNRYMPF QDIRSDCSKI AANFAAGCEL LGVNFHSEEL
LIDQKPIEIA EKYGLIKFVW GDDLNSKEVQ KHFRDEMNVD GLIFDRIGED EVLKQNVFVV
ENHNRSSLFA RSQHNSRSPS MSRRCMSTVE
