GPDP1_ARATH
ID GPDP1_ARATH Reviewed; 391 AA.
AC Q940M0; Q9SH49;
DT 26-FEB-2020, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=G-patch domain-containing protein 1 {ECO:0000303|PubMed:29375609};
GN Name=GDP1 {ECO:0000303|PubMed:29375609};
GN OrderedLocusNames=At1g63980 {ECO:0000312|Araport:AT1G63980};
GN ORFNames=F22C12.25 {ECO:0000312|EMBL:AAF24571.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP FUNCTION, DISRUPTION PHENOTYPE, SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RC STRAIN=cv. Columbia;
RX PubMed=29375609; DOI=10.3389/fpls.2017.02240;
RA Kojima K., Tamura J., Chiba H., Fukada K., Tsukaya H., Horiguchi G.;
RT "Two nucleolar proteins, GDP1 and OLI2, function as ribosome biogenesis
RT factors and are preferentially involved in promotion of leaf cell
RT proliferation without strongly affecting leaf adaxial-abaxial patterning in
RT Arabidopsis thaliana.";
RL Front. Plant Sci. 8:2240-2240(2017).
CC -!- FUNCTION: Involved in ribosome biogenesis, required for normal
CC progression of rRNA processing (PubMed:29375609). Seems to promote cell
CC proliferation in leaves (PubMed:29375609).
CC {ECO:0000269|PubMed:29375609}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}.
CC Nucleus, nucleolus {ECO:0000269|PubMed:29375609}.
CC -!- TISSUE SPECIFICITY: Strongly expressed in tissues with high cell
CC proliferation activity that have a high demand for ribosome production
CC such as shoot tips, leaves primordia, root tips and floral buds.
CC {ECO:0000269|PubMed:29375609}.
CC -!- DISRUPTION PHENOTYPE: Reduced leaf cell number associated with pointed
CC leaves shape (PubMed:29375609). Defects in pre-rRNA processing
CC characterized by an increased accumulation of rRNA intermediates
CC containing 50-ETS, ITS1, or ITS2 (PubMed:29375609). Higher levels of
CC 35S, 27SA, 27SB, P-A3, and 18SA3 rRNAs (PubMed:29375609). The double
CC mutant gdp1 oli2 exhibit strong growth defect due to a synergistically
CC impaired cell proliferation in leaves and enlarged cells
CC (PubMed:29375609). {ECO:0000269|PubMed:29375609}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF24571.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC007764; AAF24571.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE34176.1; -; Genomic_DNA.
DR EMBL; AY054272; AAL06931.1; -; mRNA.
DR EMBL; BT002689; AAO11605.1; -; mRNA.
DR RefSeq; NP_564820.1; NM_105071.4.
DR AlphaFoldDB; Q940M0; -.
DR SMR; Q940M0; -.
DR STRING; 3702.AT1G63980.1; -.
DR iPTMnet; Q940M0; -.
DR PaxDb; Q940M0; -.
DR PRIDE; Q940M0; -.
DR ProteomicsDB; 185442; -.
DR EnsemblPlants; AT1G63980.1; AT1G63980.1; AT1G63980.
DR GeneID; 842701; -.
DR Gramene; AT1G63980.1; AT1G63980.1; AT1G63980.
DR KEGG; ath:AT1G63980; -.
DR Araport; AT1G63980; -.
DR TAIR; locus:2024608; AT1G63980.
DR eggNOG; KOG2809; Eukaryota.
DR InParanoid; Q940M0; -.
DR OMA; MFYEDDQ; -.
DR OrthoDB; 855263at2759; -.
DR PhylomeDB; Q940M0; -.
DR PRO; PR:Q940M0; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q940M0; baseline and differential.
DR GO; GO:0005730; C:nucleolus; IDA:UniProtKB.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0042127; P:regulation of cell population proliferation; IMP:UniProtKB.
DR GO; GO:0090069; P:regulation of ribosome biogenesis; IMP:UniProtKB.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR InterPro; IPR000467; G_patch_dom.
DR Pfam; PF01585; G-patch; 1.
DR SMART; SM00443; G_patch; 1.
DR PROSITE; PS50174; G_PATCH; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome; Ribosome biogenesis; rRNA processing.
FT CHAIN 1..391
FT /note="G-patch domain-containing protein 1"
FT /id="PRO_0000448883"
FT DOMAIN 15..61
FT /note="G-patch"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00092"
FT REGION 80..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 212..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 305..312
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT COMPBIAS 243..265
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 266..296
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 391 AA; 43439 MW; 3AC66B81ACB11CE2 CRC64;
MAAPEAPVKY VGICKDSAAF KLMKSMGWEE GEGLGKDKQG IKGYVRVTNK QDTSGVGLDK
PNPWAFDTTQ FDNILKKLKV QAAPTKTSKN DDDSDKEDES EDDAVKSEPA KLKTVAKVTR
PQGRYKRREK GKLVNSYSSK DLEGILVKRT EDPSPAVCDI ADSMDIEIIS EDQDASIKEQ
KIEEPSSNWW GFKSGFVSGG LLGAKSGKKK LKASERKMFS ENDQENLYNM VQDKATAGKQ
GLGIKDRPKK IAGVRYEGKK TSFDNSDDDD DDDDDDDEED EEEDEDESEA DDDDKDSVIE
SSLPAKRKHD EIIEPKIKLK NLCKQIVKKD AGKGGFMKLK QLKSLIDEQA PSVLSEFSSR
KDAIAYLKLK LERSGKFVVE GKKISLVSSK K
